Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Schlenker, T., J. M. J. Romac, A. I. Sharara, R. M. Roman, S. J. Kim, N. Larusso, R. A. Liddle, and J. Gregory Fitz. “Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes.” American Journal of Physiology  Gastrointestinal and Liver Physiology 273, no. 5 36-5 (December 9, 1997).

Scholars@Duke

Spannagel, A. W., J. R. Reeve, R. A. Liddle, D. Guan, and G. M. Green. “An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.” American Journal of Physiology 273, no. 3 PART 1 (December 1, 1997).

Scholars@Duke

Tarasova, N., A. W. Spannagel, G. M. Green, G. Gomez, J. T. Reed, J. C. Thompson, M. R. Hellmich, J. R. Reeve, R. A. Liddle, and G. H. Greeley. “Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract..” Endocrinology 138, no. 12 (December 1997): 5550–54. https://doi.org/10.1210/endo.138.12.5554.

PMID
9389543
Full Text

Schlenker, T., J. M. Romac, A. I. Sharara, R. M. Roman, S. J. Kim, N. LaRusso, R. A. Liddle, and J. G. Fitz. “Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes..” Am J Physiol 273, no. 5 (November 1997): G1108–17. https://doi.org/10.1152/ajpgi.1997.273.5.G1108.

PMID
29585439
Full Text

Spannagel, A. W., J. R. Reeve, R. A. Liddle, D. Guan, and G. M. Green. “An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.” American Journal of Physiology  Gastrointestinal and Liver Physiology 273, no. 3 36-3 (September 1, 1997).

Scholars@Duke

Spannagel, A. W., J. R. Reeve, R. A. Liddle, D. F. Guan, and G. M. Green. “An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.” American Journal of Physiology Gastrointestinal and Liver Physiology 273, no. 3 (September 1, 1997): G754–58.

Scholars@Duke

Spannagel, A. W., J. R. Reeve, R. A. Liddle, D. Guan, and G. M. Green. “An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide..” Am J Physiol 273, no. 3 Pt 1 (September 1997): G754–58. https://doi.org/10.1152/ajpgi.1997.273.3.G754.

PMID
9316481
Full Text

Spannagel, A. W., G. H. Greeley, K. W. Xu, R. A. Liddle, J. R. Reeve, E. Kraig, and G. M. Green. “Role of luminal CCK releasing factor (LCRF) and GRP in pancreatic response to bile pancreatic juice diversion (BPJD)..” In Gastroenterology, 112:A1190–A1190. W B SAUNDERS CO-ELSEVIER INC, 1997.

Scholars@Duke

Prpic, V., J. G. Fitz, J. R. Raymond, M. Garnovskaya, and R. A. Liddle. “Inhibition of Na+/H+ exchange stimulates cholecystokinin secretion in STC-1 cells..” In Gastroenterology, 112:A1182–A1182. W B SAUNDERS CO-ELSEVIER INC, 1997.

Scholars@Duke

Devlin, M. J., B. T. Walsh, J. L. Guss, H. R. Kissileff, R. A. Liddle, and E. Petkova. “Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa..” Am J Clin Nutr 65, no. 1 (January 1997): 114–20. https://doi.org/10.1093/ajcn/65.1.114.

PMID
8988922
Full Text

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