Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Vigna, SR, Shahid, RA, and Liddle, RA. "The Role of TRPV1 in Ethanol Plus Fatty Acid-Induced Acute Pancreatitis in Mice." May 2012.

Scholars@Duke

Romac, JM-J, Shahid, RA, Choi, SS, Karaca, GF, Westphalen, CB, Wang, TC, and Liddle, RA. "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas." American Journal of Physiology. Gastrointestinal and Liver Physiology 302, no. 5 (March 2012): G535-G541.

PMID
22173919
Full Text

Liddle, RA. "2012 American pancreatic association presidential address: Fostering translation." Pancreas 41, no. 8 (2012): 1165-1166.

PMID
23086240
Full Text

Balmadrid, BL, Thomas, CM, Coffman, CJ, Liddle, RA, and Fisher, DA. "Factors associated with survival of veterans with gastrointestinal neuroendocrine tumors." J Cancer Epidemiol 2012 (2012): 986708-.

PMID
22693504
Full Text

Liddle, RA. "Regulation of Pancreatic Secretion." Physiology of the Gastrointestinal Tract 2 (2012): 1425-1460.

Full Text

Diamond, P, and Liddle, R. "Aftershock: The post-crisis social investment welfare state in Europe." In Towards a Social Investment Welfare State?: Ideas, Policies and Challenges, 285-308. November 30, 2011.

Scholars@Duke

Bohórquez, DV, and Liddle, RA. "Axon-like basal processes in enteroendocrine cells: characteristics and potential targets." Clinical and Translational Science 4, no. 5 (October 2011): 387-391. (Review)

PMID
22029814
Full Text

Chandra, R, and Liddle, RA. "Recent advances in pancreatic endocrine and exocrine secretion." Current Opinion in Gastroenterology 27, no. 5 (September 2011): 439-443. (Review)

PMID
21778879
Full Text

Vigna, SR, Shahid, RA, Nathan, JD, McVey, DC, and Liddle, RA. "Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats." Pancreas 40, no. 5 (July 2011): 708-714.

PMID
21602738
Full Text

Bohorquez, DV, Vigna, SR, and Liddle, RA. "PYY-Secreting L Cells Connect to Enteric Myofibroblasts and Neurites Through Axon-Like Basal Processes." May 2011.

Scholars@Duke

Pages