Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@mc.duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebannon), 1993

Publications

Al-Khatib, SM, Stebbins, AL, Califf, RM, Lee, KL, Granger, CB, White, HD, Armstrong, PW, Topol, EJ, Ohman, EM, and GUSTO-III trial, . "Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: results from the GUSTO-III trial." American Heart Journal 145, no. 3 (March 2003): 515-521.

PMID
12660676
Full Text

Curtis, LH, Østbye, T, Sendersky, V, Hutchison, S, Allen LaPointe, NM, Al-Khatib, SM, Usdin Yasuda, S, Dans, PE, Wright, A, Califf, RM, Woosley, RL, and Schulman, KA. "Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients." The American Journal of Medicine 114, no. 2 (February 2003): 135-141.

PMID
12586234
Full Text

Al-Khatib, SM, LaPointe, NMA, Curtis, LH, Kramer, JM, Swann, J, Honig, P, and Califf, RM. "Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000." The American Journal of Cardiology 91, no. 1 (January 2003): 91-94.

PMID
12505582
Full Text

Anderson, ME, Al-Khatib, SM, Roden, DM, Califf, RM, and Duke Clinical Research Institute/American Heart Journal Expert Meeting on Repolarization Changes, . "Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management." American Heart Journal 144, no. 5 (November 2002): 769-781. (Review)

PMID
12422144
Full Text

Al-Khatib, SM, Granger, CB, Huang, Y, Lee, KL, Califf, RM, Simoons, ML, Armstrong, PW, Van de Werf, F, White, HD, Simes, RJ, Moliterno, DJ, Topol, EJ, and Harrington, RA. "Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes." Circulation 106, no. 3 (July 2002): 309-312.

PMID
12119245
Full Text

LaPointe, NMA, Al-Khatib, SM, Kramer, JM, Battle, J, and Califf, RM. "Deficits in knowledge related to the QT interval that could impact patient safety." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 39, no. 5 (March 6, 2002): 125A-125A.

Scholars@Duke

Rebeiz, AG, and Al-Khatib, SM. "A case of severe ischemia-induced QT prolongation." Clin Cardiol 24, no. 11 (November 2001): 750-.

PMID
11714133
Scholars@Duke

Al-Khatib, SMN, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Short-term trials and long-term effects - Response." SCIENCE 293, no. 5539 (September 28, 2001): 2393-2394.

Scholars@Duke

Daniels, SR. "Short-term trials and long-term effects." Science (New York, N.Y.) 293, no. 5539 (September 2001): 2392-2394. (Letter)

PMID
11579936
Full Text

Al-Khatib, SM, Pieper, KS, Lee, KL, Mahaffey, KW, Hochman, JS, Pepine, CJ, Kopecky, SL, Akkerhuis, M, Stepinska, J, Simoons, ML, Topol, EJ, Califf, RM, and Harrington, RA. "Atrial fibrillation and mortality among patients with acute coronary syndromes without ST-segment elevation: results from the PURSUIT trial." The American Journal of Cardiology 88, no. 1 (July 2001): A7-79.

PMID
11423065
Full Text

Pages