Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Core Faculty in Innovation & Entrepreneurship
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address scott.palmer@duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Belperio, J, Palmer, SM, and Weigt, SS. "Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction." Annals of the American Thoracic Society 14, no. Supplement_3 (September 2017): S242-S246.

PMID
28945471
Full Text

Brass, DM, and Palmer, SM. "Models of toxicity of diacetyl and alternative diones." Toxicology 388 (August 2017): 15-20. (Review)

PMID
28232124
Full Text

Petrovski, S, Todd, JL, Durheim, MT, Wang, Q, Chien, JW, Kelly, FL, Frankel, C, Mebane, CM, Ren, Z, Bridgers, J, Urban, TJ, Malone, CD, Finlen Copeland, A, Brinkley, C, Allen, AS, O'Riordan, T, McHutchison, JG, Palmer, SM, and Goldstein, DB. "An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine 196, no. 1 (July 2017): 82-93.

PMID
28099038
Full Text

Castleberry, A, Mulvihill, MS, Yerokun, BA, Gulack, BC, Englum, B, Snyder, L, Worni, M, Osho, A, Palmer, S, Davis, RD, and Hartwig, MG. "The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation 36, no. 7 (July 2017): 780-786.

PMID
28131666
Full Text

Brass, DM, Gwinn, WM, Valente, AM, Kelly, FL, Brinkley, CD, Nagler, AE, Moseley, MA, Morgan, DL, Palmer, SM, and Foster, MW. "The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease." American journal of respiratory cell and molecular biology 56, no. 6 (June 2017): 784-795.

PMID
28248570
Full Text

Todd, JL, and Palmer, SM. "Danger signals in regulating the immune response to solid organ transplantation." The Journal of Clinical Investigation 127, no. 7 (June 2017): 2464-2472. (Review)

PMID
28530643
Full Text

Osho, AA, Castleberry, AW, Yerokun, BA, Mulvihill, MS, Rucker, J, Snyder, LD, Davis, RD, and Hartwig, MG. "Clinical predictors and outcome implications of early readmission in lung transplant recipients." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation 36, no. 5 (May 2017): 546-553.

PMID
27932071
Full Text

Smith, PJ, Palmer, SM, Snyder, LD, Hoffman, BM, Ingle, KK, Stonerock, GL, Saulino, C, and Blumenthal, JA. "Depressive Symptoms and Post-Transplant Mortality: Examining the Influence of Perioperative Outcomes." April 2017.

Scholars@Duke

Klement, W, Tikkanen, J, Juvet, S, Todd, JL, Weigt, SS, Snyder, LD, Azad, S, Belperio, JA, Palmer, SM, Singer, LG, Keshavjee, S, and Martinu, T. "Automating the Diagnosis of Potential CLAD and Its Subtypes in Lung Transplant Recipients." April 2017.

Scholars@Duke

Smith, PJ, Blumenthal, JA, Snyder, LD, Rivelli, S, and Palmer, SM. "Perceived Cognitive Difficulties and Quality of Life following Lung Transplantation." April 2017.

Scholars@Duke

Pages