Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address palme002@mc.duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Smith, PJ, Blumenthal, JA, Snyder, LD, Mathew, JP, Durheim, MT, Hoffman, BM, Rivelli, SK, and Palmer, SM. "Depressive symptoms and early mortality following lung transplantation: A pilot study." Clinical transplantation 31, no. 2 (February 2017).

PMID
27859626
Full Text

Foster, MW, Gwinn, WM, Kelly, FL, Brass, DM, Valente, AM, Moseley, MA, Thompson, JW, Morgan, DL, and Palmer, SM. "Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl." Journal of proteome research 16, no. 2 (February 2017): 538-549.

PMID
27966365
Full Text

Weigt, SS, Wang, X, Palchevskiy, V, Gregson, AL, Patel, N, DerHovanessian, A, Shino, MY, Sayah, DM, Birjandi, S, Lynch, JP, Saggar, R, Ardehali, A, Ross, DJ, Palmer, SM, Elashoff, D, and Belperio, JA. "Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction." PloS one 12, no. 1 (January 19, 2017): e0169894-.

PMID
28103284
Full Text

Tong, Y, Udupa, JK, Torigian, DA, Odhner, D, Wu, C, Pednekar, G, Palmer, S, Rozenshtein, A, Shirk, MA, Newell, JD, Porteous, M, Diamond, JM, Christie, JD, and Lederer, DJ. "Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates." PloS one 12, no. 1 (January 3, 2017): e0168932-.

PMID
28046024
Full Text

Kelly, FL, Weinberg, KE, Nagler, AE, Brass, DM, Palmer, SM, and RCMB, . "Diacetyl-Induced Il-8 Production Is Mediated By EGFR And Erk 1/2 Activation In Pulmonary Epithelial Cells." 2017.

Scholars@Duke

Nagler, AE, Kelly, FL, Weinberg, KE, Palmer, SM, and Brass, DM. "EGFR Ligands Increase Mek-Dependent Hyaluronan Synthesis In Naive Rat Lung Fibroblasts." 2017.

Scholars@Duke

Weinberg, KE, Kelly, FL, Nagler, AE, Palmer, SM, and Brass, DM. "Nitrogen Mustard (mechlorethamine Hydrochloride) Induces Amphiregulin Shedding And Hyaluronan Synthesis In Human Epithelial Cells." 2017.

Scholars@Duke

Todd, JL, Foster, MW, Valente, A, Brinkley, C, Ali, HA, Reynolds, JM, Kelly, FL, and Palmer, SM. "Proteomics Of Bronchoalveolar Lavage (bal) Fluid In Bronchiolitis Obliterans Syndrome (bos)." 2017.

Scholars@Duke

Bates, CA, Frankel, CW, Gray, AL, Reynolds, JM, Palmer, SM, and Neely, ML. "Outcomes In Lung Transplant Recipients With Pulmonary Fibrosis At High Risk Of Death." 2017.

Scholars@Duke

Todd, JL, Mikels-Vigdal, AJ, Kelly, FL, Pavlisko, EN, Mikaelian, I, O'Riordan, TG, Smith, VC, and Palmer, SM. "Loxl-2 Contributes To The Development Of Obliterative Bronchiolitis (ob) In Humans." 2017.

Scholars@Duke

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