Stephen Joseph Balevic, MD

Assistant Professor of Pediatrics
Assistant Professor of Medicine
Member of the Duke Clinical Research Institute
Email address stephen.balevic@duke.edu

I am an Adult and Pediatric Rheumatologist and care for patients with a wide variety of autoimmune and rheumatic diseases, including: systemic lupus, rheumatoid arthritis, juvenile arthritis, vasculitis, and sarcoidosis, among others. I have a special interest in using musculoskeletal ultrasound to optimize diagnosis and treatment decisions at the bedside.

I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I completed my clinical and research fellowships as well as a Master of Health Science Degree in Clinical Research at Duke University. I completed clinical pharmacology training though the NICHD sponsored, UNC-Duke Clinical Pharmacology T32 Training Program. I serve as the principal investigator on several foundation grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI.

Education and Training

  • Clinical Pharmacology Fellowship, Duke And Unc School Of Pharmacy, Duke University School of Medicine, 2016 - 2018
  • Clinical Research Fellow, Dcri, Duke University School of Medicine, 2016 - 2018
  • Fellowship Adult and Pediatric, Pediatrics, Duke University School of Medicine, 2014 - 2018
  • Internal Medicine and Pediatric Residency, Medical University of South Carolina, School of Medicine, 2010 - 2014
  • M.D., Marshall University, 2010

Publications

Job, Kathleen M., André Dallmann, Samuel Parry, George Saade, David M. Haas, Brenna Hughes, Pamela Berens, et al. “Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.” Clin Pharmacol Ther 111, no. 5 (May 2022): 1111–20. https://doi.org/10.1002/cpt.2530.

PMID
35076931
Full Text

Balevic, Stephen J., Shruti M. Raja, Rachel Randell, Gregory A. Deye, Thomas Conrad, Aya Nakamura, David H. Peyton, et al. “Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions.” Infect Dis Ther 11, no. 2 (April 2022): 841–52. https://doi.org/10.1007/s40121-022-00605-z.

PMID
35184256
Full Text

Soulsby, William Daniel, Nayimisha Balmuri, Victoria Cooley, Linda M. Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta, and Bella CARRA Registry Investigators. “Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.” Pediatr Rheumatol Online J 20, no. 1 (March 7, 2022): 18. https://doi.org/10.1186/s12969-022-00676-9.

PMID
35255941
Full Text

Clowse, Megan E. B., Amanda M. Eudy, Stephen Balevic, Gillian Sanders-Schmidler, Andrzej Kosinski, Rebecca Fischer-Betz, Dafna D. Gladman, et al. “Hydroxychloroquine in the pregnancies of women with lupus: a meta-analysis of individual participant data.” Lupus Sci Med 9, no. 1 (March 2022). https://doi.org/10.1136/lupus-2021-000651.

PMID
35318256
Full Text

Balevic, Stephen J., and Anna Carmela P. Sagcal-Gironella. “Precision Medicine: Towards Individualized Dosing in Pediatric Rheumatology.” Rheum Dis Clin North Am 48, no. 1 (February 2022): 305–30. https://doi.org/10.1016/j.rdc.2021.09.010.

PMID
34798954
Full Text

Verstegen, Ruud H. J., Peter Shrader, Stephen J. Balevic, Timothy Beukelman, Colleen Correll, Anne Dennos, Thomas Phillips, Brian M. Feldman, and Brian M. CARRA Registry investigators. “Dosing Variation at Initiation of Adalimumab and Etanercept is not Associated with Clinical Outcomes in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry study.” Arthritis Care Res (Hoboken), January 18, 2022. https://doi.org/10.1002/acr.24859.

PMID
35040593
Full Text

Balevic, Stephen J., Daniel Weiner, Megan E. B. Clowse, Amanda M. Eudy, Anil R. Maharaj, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Hydroxychloroquine PK and exposure-response in pregnancies with lupus: the importance of adherence for neonatal outcomes.” Lupus Sci Med 9, no. 1 (January 2022). https://doi.org/10.1136/lupus-2021-000602.

PMID
34996856
Full Text

Gerhart, Jacqueline G., Stephen Balevic, Jaydeep Sinha, Eliana M. Perrin, Jian Wang, Andrea N. Edginton, and Daniel Gonzalez. “Characterizing Pharmacokinetics in Children With Obesity-Physiological, Drug, Patient, and Methodological Considerations.” Front Pharmacol 13 (2022): 818726. https://doi.org/10.3389/fphar.2022.818726.

PMID
35359853
Full Text

Karatza, Eleni, Samit Ganguly, Chi D. Hornik, William J. Muller, Amira Al-Uzri, Laura James, Stephen J. Balevic, and Daniel Gonzalez. “External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data.” Front Pharmacol 13 (2022): 817276. https://doi.org/10.3389/fphar.2022.817276.

PMID
35370711
Full Text

Jones, Jordan T., Chelsey Smith, Mara L. Becker, Daniel Lovell, and Daniel CARRA Registry Investigators. “Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.” In Arthritis Care Res (Hoboken), 73:1739–45, 2021. https://doi.org/10.1002/acr.24418.

PMID
33242376
Full Text

Pages