Rheumatology and Immunology

Stephen Joseph Balevic, MD

Assistant Professor of Pediatrics
Assistant Professor of Medicine
Member of the Duke Clinical Research Institute
Email address stephen.balevic@duke.edu

I am an Adult and Pediatric Rheumatologist and care for patients with a wide variety of autoimmune and rheumatic diseases, including: systemic lupus, rheumatoid arthritis, juvenile arthritis, vasculitis, and sarcoidosis, among others. I have a special interest in using musculoskeletal ultrasound to optimize diagnosis and treatment decisions at the bedside.

I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I completed my clinical and research fellowships as well as a Master of Health Science Degree in Clinical Research at Duke University. I completed clinical pharmacology training though the NICHD sponsored, UNC-Duke Clinical Pharmacology T32 Training Program. I serve as the principal investigator on several foundation grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI.

Education and Training

  • Clinical Pharmacology Fellowship, Duke And Unc School Of Pharmacy, Duke University School of Medicine, 2016 - 2018
  • Clinical Research Fellow, Dcri, Duke University School of Medicine, 2016 - 2018
  • Fellowship Adult and Pediatric, Pediatrics, Duke University School of Medicine, 2014 - 2018
  • Internal Medicine and Pediatric Residency, Medical University of South Carolina School of Medicine, 2010 - 2014
  • M.D., Marshall University, 2010

Grants

Publications

Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Dr. Balevic, et al, reply.” J Rheumatol, May 25, 2020. https://doi.org/10.3899/jrheum.200681.

PMID
32451351
Full Text

Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.” J Rheumatol, May 11, 2020. https://doi.org/10.3899/jrheum.200493.

PMID
32393664
Full Text

Thompson, Elizabeth J., Huali Wu, Chiara Melloni, Stephen Balevic, Janice E. Sullivan, Matthew Laughon, Kira M. Clark, et al. “Population Pharmacokinetics of Doxycycline in Children.” Antimicrob Agents Chemother, September 23, 2019. https://doi.org/10.1128/AAC.01508-19.

PMID
31548185
Full Text

Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

PMID
30944398
Full Text

Thompson, Elizabeth J., Huali Wu, Anil Maharaj, Andrea N. Edginton, Stephen J. Balevic, Marjan Cobbaert, Anthony P. Cunningham, Christoph P. Hornik, and Michael Cohen-Wolkowiez. “Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children.” Clin Pharmacokinet 58, no. 7 (July 2019): 887–98. https://doi.org/10.1007/s40262-018-00733-1.

PMID
30840200
Full Text

Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants.” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.

PMID
30710387
Full Text

Balevic, Stephen J., Thomas P. Green, Megan E. B. Clowse, Amanda M. Eudy, Laura E. Schanberg, and Michael Cohen-Wolkowiez. “Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases.” Clin Pharmacokinet 58, no. 4 (April 2019): 525–33. https://doi.org/10.1007/s40262-018-0712-z.

PMID
30255310
Full Text

Balevic, Stephen J., Michael Cohen-Wolkowiez, Amanda M. Eudy, Thomas P. Green, Laura E. Schanberg, and Megan E. B. Clowse. “Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.” J Rheumatol 46, no. 1 (January 2019): 57–63. https://doi.org/10.3899/jrheum.180158.

PMID
30275257
Full Text

Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.

PMID
30193125
Full Text

Balevic, Stephen J., and Michael Cohen-Wolkowiez. “Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children.” J Clin Pharmacol 58 Suppl 10 (October 2018): S58–72. https://doi.org/10.1002/jcph.1053.

PMID
30248192
Full Text

Pages