Stephen Lowe Young, MD

Professor Emeritus of Medicine
Campus mail A5012 VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-6946
Email address stephen.young@duke.edu

Although I no longer am actively involved in research, my prior work experience is given below:

My laboratory work focussed upon the cell biology of the lung epithelium: during development, including the processes of branching morphogenesis and second, during the maintenence of lung surface forces through the epithelial secretion known as surfactant.

We emphasized a morphologic approach utilizing the full range of ultrastructural techniques, supplemented with molecular biologic techniques that allow structure function correlations.

I have been involved in clinical trials examining vaccination against influenza and examining the value of inhaled steroids, both experiments in patients with COPD.

I am recognized mainly for work in surfactant and lung development.

Lung surfactant; alveolar type II cell; branching morphogenesis; lung development

Education and Training

  • M.D., University of California, San Francisco, School of Medicine, 1968

Publications

Piantadosi, CA, Bartz, RR, Carraway, MS, Ghio, AJ, McMahon, TJ, Murdoch, DM, Roggli, VL, Shofer, SL, Tighe, RM, Welty-Wolf, KE, and Young, SL. "The opprobrium of Big Tobacco." Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030-. (Letter)

PMID
22550218
Full Text

Gorse, GJ, O'connor, TZ, Young, SL, Habib, MP, Wittes, J, Neuzil, KM, and Nichol, KL. "Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination." Chest 130, no. 4 (October 2006): 1109-1116.

PMID
17035445
Full Text

Roggli, VL, Piantadosi, CA, MacIntyre, NR, Young, SL, Kussin, PS, Steele, MP, Carraway, MS, Welty-Wolf, KE, Govert, JA, McMahon, TJ, Palmer, SM, Sporn, TA, and Ghio, AJ. "Physician subsidies for tobacco advertising." Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246-. (Letter)

PMID
16391304
Full Text

Randell, SH, and Young, SL. "Structure of Alveolar Epithelial Cells and the Surface Layer During Development." In Fetal and Neonatal Physiology: Third Edition, 1034-1040. December 1, 2003.

Full Text

Gorse, GJ, O'Connor, TZ, Young, SL, Mendelman, PM, Bradley, SF, Nichol, KL, Strickland, JH, Paulson, DM, Rice, KL, Foster, RA, Fulambarker, AM, Shigeoka, JW, Kuschner, WG, Goodman, RP, Neuzil, KM, Wittes, J, Boardman, KD, and Peduzzi, PN. "Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study." Vaccine 21, no. 17-18 (May 2003): 2133-2144.

PMID
12706704
Full Text

Young, SL, Evans, K, and Eu, JP. "Nitric oxide modulates branching morphogenesis in fetal rat lung explants." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 3 (March 2002): L379-L385.

PMID
11839530
Full Text

Savov, J, Wright, JR, and Young, SL. "Incorporation of biotinylated SP-A into rat lung surfactant layer, type II cells, and clara cells." American Journal of Physiology. Lung Cellular and Molecular Physiology 279, no. 1 (July 2000): L118-L126.

PMID
10893210
Full Text

Zhao, Y, Young, SL, McIntosh, JC, Steele, MP, and Silbajoris, R. "Ontogeny and localization of TGF-beta type I receptor expression during lung development." American Journal of Physiology. Lung Cellular and Molecular Physiology 278, no. 6 (June 2000): L1231-L1239.

PMID
10835329
Full Text

Sachs, S, Ghio, AJ, and Young, SL. "Tyloxapol confers durable protection against hyperoxic lung injury in the rat." Exp Lung Res 25, no. 6 (September 1999): 543-559.

PMID
10533679
Scholars@Duke

Savov, J, Silbajoris, R, and Young, SL. "Mechanical ventilation of rat lung: effect on surfactant forms." The American Journal of Physiology 277, no. 2 (August 1999): L320-L326.

PMID
10444526
Full Text

Pages