Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #301, Durham, NC 27710
Phone (919) 684-8111
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Juliano, JJ, Barnett, E, Parobek, CM, Taylor, SM, Meshnick, SR, Stone, S, Chang, E, Fong, S, and Huang, L. "Use of Oropharyngeal Washes to Diagnose and Genotype Pneumocystis jirovecii." Open forum infectious diseases 2, no. 3 (September 2015): ofv080-.

PMID
26180832
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Gutman, J, Kalilani, L, Taylor, S, Zhou, Z, Wiegand, RE, Thwai, KL, Mwandama, D, Khairallah, C, Madanitsa, M, Chaluluka, E, Dzinjalamala, F, Ali, D, Mathanga, DP, Skarbinski, J, Shi, YP, Meshnick, S, and ter Kuile, FO. "The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women." The Journal of Infectious Diseases 211, no. 12 (June 2015): 1997-2005.

PMID
25564249
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Chandrasiri, UP, Fowkes, FJI, Richards, JS, Langer, C, Fan, Y-M, Taylor, SM, Beeson, JG, Dewey, KG, Maleta, K, Ashorn, P, and Rogerson, SJ. "The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial." Malaria journal 14 (May 10, 2015): 193-.

PMID
25957793
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Carrel, M, Patel, J, Taylor, SM, Janko, M, Mwandagalirwa, MK, Tshefu, AK, Escalante, AA, McCollum, A, Alam, MT, Udhayakumar, V, Meshnick, S, and Emch, M. "The geography of malaria genetics in the Democratic Republic of Congo: A complex and fragmented landscape." Social science & medicine (1982) 133 (May 2015): 233-241.

PMID
25459204
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O'Meara, WP, Mott, JA, Laktabai, J, Wamburu, K, Fields, B, Armstrong, J, Taylor, SM, MacIntyre, C, Sen, R, Menya, D, Pan, W, Nicholson, BP, Woods, CW, and Holland, TL. "Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis." The American Journal of Tropical Medicine and Hygiene 92, no. 5 (May 2015): 1030-1037.

PMID
25758648
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Lopera-Mesa, TM, Doumbia, S, Konaté, D, Anderson, JM, Doumbouya, M, Keita, AS, Diakité, SA, Traoré, K, Krause, MA, Diouf, A, Moretz, SE, STullo, G, Miura, K, Gu, W, Fay, MP, Taylor, SM, Long, CA, Diakité, M, and Fairhurst, RM. "Impact of red blood cell variants on childhood malaria in Mali: a prospective cohort study." The Lancet. Haematology 2, no. 4 (April 2015): e140-e149.

PMID
25954766
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Lopera-Mesa, TM, Doumbia, S, Konaté, D, Anderson, JM, Doumbouya, M, Keita, AS, Diakité, SAS, Traoré, K, Krause, MA, Diouf, A, Moretz, SE, Tullo, GS, Miura, K, Gu, W, Fay, MP, Taylor, SM, Long, CA, Diakité, M, and Fairhurst, RM. "Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study." The Lancet. Haematology 2, no. 4 (April 2015): e140-e149.

PMID
26687956
Full Text

Taylor, SM, Parobek, CM, DeConti, DK, Kayentao, K, Coulibaly, SO, Greenwood, BM, Tagbor, H, Williams, J, Bojang, K, Njie, F, Desai, M, Kariuki, S, Gutman, J, Mathanga, DP, Mårtensson, A, Ngasala, B, Conrad, MD, Rosenthal, PJ, Tshefu, AK, Moormann, AM, Vulule, JM, Doumbo, OK, Ter Kuile, FO, Meshnick, SR, Bailey, JA, and Juliano, JJ. "Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study." The Journal of Infectious Diseases 211, no. 5 (March 2015): 680-688.

PMID
25180240
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Tagbor, H, Cairns, M, Bojang, K, Coulibaly, SO, Kayentao, K, Williams, J, Abubakar, I, Akor, F, Mohammed, K, Bationo, R, Dabira, E, Soulama, A, Djimdé, M, Guirou, E, Awine, T, Quaye, S, Njie, F, Ordi, J, Doumbo, O, Hodgson, A, Oduro, A, Meshnick, S, Taylor, S, Magnussen, P, ter Kuile, F, Woukeu, A, Milligan, P, Chandramohan, D, and Greenwood, B. "A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy." Plos One 10, no. 8 (January 2015): e0132247-null.

PMID
26258474
Full Text

Chandrasiri, UP, Fowkes, F, Richards, JS, Langer, C, Fan, Y-M, Taylor, SM, Beeson, JG, Dewey, KG, Maleta, K, Ashorn, P, and Rogerson, SJ. "The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial." Malaria Journal (2015).

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