Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #321a, Durham, NC 27710
Phone (919) 684-5815
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Desai, Meghna, Julie Gutman, Steve M. Taylor, Ryan E. Wiegand, Carole Khairallah, Kassoum Kayentao, Peter Ouma, et al. “Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight..” Clin Infect Dis 62, no. 3 (February 1, 2016): 323–33. https://doi.org/10.1093/cid/civ881.

PMID
26486699
Full Text

Patel, Jaymin C., Steve M. Taylor, Christian M. Parobek, Nicholas J. Hathaway, Kyaw L. Thwai, Mwayi Madanitsa, Victor Mwapasa, et al. “USE OF LONG-READ DEEP-SEQUENCING TO CHARACTERIZE GENETIC DIVERSITY AND PATHOGENIC VARIANTS OF VAR2CSA IN WOMEN WITH PLACENTAL MALARIA.” In American Journal of Tropical Medicine and Hygiene, 93:279–279. AMER SOC TROP MED & HYGIENE, 2015.

Scholars@Duke

Lopera-Mesa, Tatiana M., Saibou Doumbia, Drissa Konate, Jennifer M. Anderson, Mory Doumbouya, Abdoul S. Keita, Seidina A. Diakite, et al. “A FOUR-YEAR PROSPECTIVE STUDY OF THE IMPACT OF RED BLOOD CELL VARIANTS ON CHILDHOOD FALCIPARUM MALARIA IN SOUTHERN MALI.” In American Journal of Tropical Medicine and Hygiene, 93:385–385. AMER SOC TROP MED & HYGIENE, 2015.

Scholars@Duke

Patel, Jaymin C., Victor Mwapasa, Linda Kalilani, Feiko O. ter Kuile, Carole Khairallah, Kyaw L. Thwai, Steven R. Meshnick, and Steve M. Taylor. “ABSENCE OF EFFECT OF HETEROZYGOUS HEMOGLOBIN S ON THE PREVALENCE OF PLACENTAL MALARIA AND LOW BIRTH WEIGHT.” In American Journal of Tropical Medicine and Hygiene, 93:474–75. AMER SOC TROP MED & HYGIENE, 2015.

Scholars@Duke

Miller, Robin H., Nicholas J. Hathaway, Oksana Kharabora, Kashamuka Mwandagalirwa, Antoinette Tshefu, Steven R. Meshnick, Steve M. Taylor, Jeffrey A. Bailey, Jonathan J. Juliano, and V Ann Stewart. “A DEEP SEQUENCING APPROACH TO ESTIMATE MALARIA COMPLEXITY OF INFECTION IN THE DEMOCRATIC REPUBLIC OF CONGO.” In American Journal of Tropical Medicine and Hygiene, 93:280–280. AMER SOC TROP MED & HYGIENE, 2015.

Scholars@Duke

Juliano, Jonathan J., Eric Barnett, Christian M. Parobek, Steve M. Taylor, Steven R. Meshnick, Stephen Stone, Emily Chang, Serena Fong, and Laurence Huang. “Use of Oropharyngeal Washes to Diagnose and Genotype Pneumocystis jirovecii..” Open Forum Infect Dis 2, no. 3 (September 2015). https://doi.org/10.1093/ofid/ofv080.

PMID
26180832
Full Text

Gutman, Julie, Linda Kalilani, Steve Taylor, Zhiyong Zhou, Ryan E. Wiegand, Kyaw L. Thwai, Dyson Mwandama, et al. “The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women..” J Infect Dis 211, no. 12 (June 15, 2015): 1997–2005. https://doi.org/10.1093/infdis/jiu836.

PMID
25564249
Full Text

Chandrasiri, Upeksha P., Freya J. I. Fowkes, Jack S. Richards, Christine Langer, Yue-Mei Fan, Steve M. Taylor, James G. Beeson, et al. “The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial..” Malar J 14 (May 10, 2015). https://doi.org/10.1186/s12936-015-0707-2.

PMID
25957793
Full Text

Carrel, Margaret, Jaymin Patel, Steve M. Taylor, Mark Janko, Melchior Kashamuka Mwandagalirwa, Antoinette K. Tshefu, Ananias A. Escalante, et al. “The geography of malaria genetics in the Democratic Republic of Congo: A complex and fragmented landscape..” Soc Sci Med 133 (May 2015): 233–41. https://doi.org/10.1016/j.socscimed.2014.10.037.

PMID
25459204
Full Text

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