Steven Daniel Crowley, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address crowl004@mc.duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Within the Duke O'Brien Center for Kidney Research (DOCK), I am the director of the Enrichment Core seeking to facilitate training for the broader research community in the skills and strategies used in the study of renal and cardiovascular disease.

I am a leader of the one of the Stead Academic Societies called the Warren Society that seeks to provide social, service, and research opportunities for a group of residents from the internal medicine training program.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Publications

Tang, T-T, Lv, L-L, Pan, M-M, Wen, Y, Wang, B, Li, Z-L, Wu, M, Wang, F-M, Crowley, SD, and Liu, B-C. "Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation." Cell death & disease 9, no. 3 (March 2, 2018): 351-.

PMID
29500339
Full Text

Wen, Y, and Crowley, SD. "Renal effects of cytokines in hypertension." Current opinion in nephrology and hypertension 27, no. 2 (March 2018): 70-76.

PMID
29140820
Full Text

Lv, L-L, Feng, Y, Wen, Y, Wu, W-J, Ni, H-F, Li, Z-L, Zhou, L-T, Wang, B, Zhang, J-D, Crowley, SD, and Liu, B-C. "Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation." Journal of the American Society of Nephrology : JASN 29, no. 3 (March 2018): 919-935.

PMID
29295871
Full Text

Wyatt, CM, and Crowley, SD. "Intersection of salt- and immune-mediated mechanisms of hypertension in the gut microbiome." Kidney international 93, no. 3 (March 2018): 532-534.

PMID
29475542
Full Text

Rucker, AJ, Rudemiller, NP, and Crowley, SD. "Salt, Hypertension, and Immunity." Annual review of physiology 80 (February 2018): 283-307.

PMID
29144825
Full Text

Wyatt, CM, and Crowley, SD. "A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response." Kidney international 92, no. 6 (December 2017): 1308-1311.

PMID
29153132
Full Text

Crowley, SD, and Rudemiller, NP. "Immunologic Effects of the Renin-Angiotensin System." Journal of the American Society of Nephrology : JASN 28, no. 5 (May 2017): 1350-1361. (Review)

PMID
28151411
Full Text

Rudemiller, NP, and Crowley, SD. "The role of chemokines in hypertension and consequent target organ damage." Pharmacological research 119 (May 2017): 404-411. (Review)

PMID
28279813
Full Text

Justin Rucker, A, and Crowley, SD. "The role of macrophages in hypertension and its complications." Pflugers Archiv : European journal of physiology 469, no. 3-4 (April 2017): 419-430. (Review)

PMID
28251313
Full Text

Wu, M, Zhang, J-D, Tang, R-N, Crowley, SD, Liu, H, Lv, L-L, Ma, K-L, and Liu, B-C. "Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells." American journal of physiology. Renal physiology 312, no. 3 (March 2017): F436-F444.

PMID
27582099
Full Text

Pages