Steven Daniel Crowley, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996


Li, Zuo-Lin, Bin Wang, Lin-Li Lv, Tao-Tao Tang, Yi Wen, Jing-Yuan Cao, Xiao-Xiao Zhu, Song-Tao Feng, Steven D. Crowley, and Bi-Cheng Liu. “FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.” Acta Pharmacol Sin, March 3, 2021.

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Sparks, Matthew A., Fitra Rianto, Edward Diaz, Ritika Revoori, Thien Hoang, Lucas Bouknight, Johannes Stegbauer, et al. “Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.” Hypertension 77, no. 2 (February 2021): 393–404.

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Huang, Hsin-I, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, et al. “Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.” In Front Immunol, 12:661290, 2021.

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Sparks, Matthew A., Andrew M. South, Andrew D. Badley, Carissa M. Baker-Smith, Daniel Batlle, Biykem Bozkurt, Roberto Cattaneo, et al. “Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices.” Hypertension 76, no. 5 (November 2020): 1350–67.

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Tang, Tao-Tao, Bin Wang, Min Wu, Zuo-Lin Li, Ye Feng, Jing-Yuan Cao, Di Yin, et al. “Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI.” Sci Adv 6, no. 33 (August 2020): eaaz0748.

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Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A. Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.” Elife 9 (April 17, 2020).

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