Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.
Within the Duke O'Brien Center for Kidney Research (DOCK), I am the director of the Enrichment Core seeking to facilitate training for the broader research community in the skills and strategies used in the study of renal and cardiovascular disease.
I am a leader of the one of the Stead Academic Societies called the Warren Society that seeks to provide social, service, and research opportunities for a group of residents from the internal medicine training program.
Education and Training
- Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
- Chief Medical Resident, Medicine, Duke University, 2000 - 2001
- Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
- Medical Resident, Medicine, Duke University, 1996 - 1999
- M.D., Duke University, 1996
- Duke Training Grant in Nephrology
- Role of Dendritic Cell-mediated T Cell Activation in Salt-sensitive Hypertension
- The role of macrophage IL-1 signaling in acute kidney injury and recovery
- The role of dendritic cell-mediated T cell activation in hypertension
- Role of Th1 Immune Responses in the Pathogenesis of Hypertensive Kidney Injury
- Role of Drebrin in Vascular Smooth Muscle Remodeling