Nephrology

Steven Daniel Crowley, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address steven.d.crowley@duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Grants

Publications

Privratsky, JR, Zhang, J, Lu, X, Rudemiller, N, Wei, Q, Yu, Y-R, Gunn, MD, and Crowley, SD. "Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury." American Journal of Physiology Renal Physiology 315, no. 3 (September 2018): F682-F691.

PMID
29790392
Full Text

Feng, Y, Lv, L-L, Wu, W-J, Li, Z-L, Chen, J, Ni, H-F, Zhou, L-T, Tang, T-T, Wang, F-M, Wang, B, Chen, P-S, Crowley, SD, and Liu, B-C. "Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy." The American Journal of Pathology (August 22, 2018).

PMID
30142333
Full Text

Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Wertman, V, Rudemiller, NP, McMahon, TJ, Shenoy, SK, Miller, FJ, Crowley, SD, Freedman, NJ, and Stiber, JA. "Drebrin Regulates Angiotensin II-Induced Aortic Remodeling." Cardiovascular Research (June 20, 2018).

PMID
29931051
Full Text

Tang, T-T, Lv, L-L, Pan, M-M, Wen, Y, Wang, B, Li, Z-L, Wu, M, Wang, F-M, Crowley, SD, and Liu, B-C. "Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation." Cell Death & Disease 9, no. 3 (March 2, 2018): 351-null.

PMID
29500339
Full Text

Wen, Y, and Crowley, SD. "Renal effects of cytokines in hypertension." Current Opinion in Nephrology and Hypertension 27, no. 2 (March 2018): 70-76. (Review)

PMID
29140820
Full Text

Lv, L-L, Feng, Y, Wen, Y, Wu, W-J, Ni, H-F, Li, Z-L, Zhou, L-T, Wang, B, Zhang, J-D, Crowley, SD, and Liu, B-C. "Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation." Journal of the American Society of Nephrology : JASN 29, no. 3 (March 2018): 919-935.

PMID
29295871
Full Text

Wyatt, CM, and Crowley, SD. "Intersection of salt- and immune-mediated mechanisms of hypertension in the gut microbiome." Kidney International 93, no. 3 (March 2018): 532-534.

PMID
29475542
Full Text

Rucker, AJ, Rudemiller, NP, and Crowley, SD. "Salt, Hypertension, and Immunity." Annual review of physiology 80 (February 2018): 283-307.

PMID
29144825
Full Text

Wyatt, CM, and Crowley, SD. "A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response." Kidney International 92, no. 6 (December 2017): 1308-1311.

PMID
29153132
Full Text

Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Rudemiller, NP, Crowley, SD, Freedman, NJ, and Stiber, JA. "Angiotensin II-Induced Aortic Inflammation and Remodeling Are Mitigated by the Actin-Binding Protein Drebrin." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017.

Scholars@Duke

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