Nephrology

Steven Daniel Crowley, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address steven.d.crowley@duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Grants

Publications

Privratsky, JR, Wang, N, Qi, Y, Ren, J, Morris, BT, Hunting, JC, Johnson, GA, and Crowley, SD. "Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury." American Journal of Physiology. Renal Physiology 316, no. 2 (February 2019): F351-F359.

PMID
30516426
Full Text

Li, Z-L, Lv, L-L, Tang, T-T, Wang, B, Feng, Y, Zhou, L-T, Cao, J-Y, Tang, R-N, Wu, M, Liu, H, Crowley, SD, and Liu, B-C. "HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation." Kidney International 95, no. 2 (February 2019): 388-404.

PMID
30551896
Full Text

Crowley, SD. "No energy wasted in the fight against vascular inflammation." Cardiovascular Research 114, no. 14 (December 2018): 1822-1824.

PMID
30215715
Full Text

Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Wertman, V, Rudemiller, NP, McMahon, TJ, Shenoy, SK, Miller, FJ, Crowley, SD, Freedman, NJ, and Stiber, JA. "Drebrin regulates angiotensin II-induced aortic remodelling." Cardiovascular Research 114, no. 13 (November 2018): 1806-1815.

PMID
29931051
Full Text

Feng, Y, Lv, L-L, Wu, W-J, Li, Z-L, Chen, J, Ni, H-F, Zhou, L-T, Tang, T-T, Wang, F-M, Wang, B, Chen, P-S, Crowley, SD, and Liu, B-C. "Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy." The American Journal of Pathology 188, no. 11 (November 2018): 2542-2552.

PMID
30142333
Full Text

Crowley, SD. "ATAC-ing the mechanisms of renin regulation." The Journal of Clinical Investigation 128, no. 11 (November 2018): 4748-4750.

PMID
30277477
Full Text

Lu, X, and Crowley, SD. "Inflammation in Salt-Sensitive Hypertension and Renal Damage." Current Hypertension Reports 20, no. 12 (October 30, 2018): 103-null. (Review)

PMID
30377822
Full Text

Privratsky, JR, Zhang, J, Lu, X, Rudemiller, N, Wei, Q, Yu, Y-R, Gunn, MD, and Crowley, SD. "Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury." American Journal of Physiology. Renal Physiology 315, no. 3 (September 2018): F682-F691.

PMID
29790392
Full Text

Tang, T-T, Lv, L-L, Pan, M-M, Wen, Y, Wang, B, Li, Z-L, Wu, M, Wang, F-M, Crowley, SD, and Liu, B-C. "Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation." Cell Death & Disease 9, no. 3 (March 2, 2018): 351-null.

PMID
29500339
Full Text

Wen, Y, and Crowley, SD. "Renal effects of cytokines in hypertension." Current Opinion in Nephrology and Hypertension 27, no. 2 (March 2018): 70-76. (Review)

PMID
29140820
Full Text

Pages