Steven Daniel Crowley, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address crowl004@mc.duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Within the Duke O'Brien Center for Kidney Research (DOCK), I am the director of the Enrichment Core seeking to facilitate training for the broader research community in the skills and strategies used in the study of renal and cardiovascular disease.

I am a leader of the one of the Stead Academic Societies called the Warren Society that seeks to provide social, service, and research opportunities for a group of residents from the internal medicine training program.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Publications

Crowley, SD, and Rudemiller, NP. "Immunologic Effects of the Renin-Angiotensin System." Journal of the American Society of Nephrology : JASN 28, no. 5 (May 2017): 1350-1361. (Review)

PMID
28151411
Full Text

Rudemiller, NP, and Crowley, SD. "The role of chemokines in hypertension and consequent target organ damage." Pharmacological research 119 (May 2017): 404-411. (Review)

PMID
28279813
Full Text

Justin Rucker, A, and Crowley, SD. "The role of macrophages in hypertension and its complications." Pflugers Archiv : European journal of physiology 469, no. 3-4 (April 2017): 419-430. (Review)

PMID
28251313
Full Text

Wu, M, Zhang, J-D, Tang, R-N, Crowley, SD, Liu, H, Lv, L-L, Ma, K-L, and Liu, B-C. "Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells." American journal of physiology. Renal physiology 312, no. 3 (March 2017): F436-F444.

PMID
27582099
Full Text

Rudemiller, NP, and Crowley, SD. "Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry." Methods in molecular biology (Clifton, N.J.) 1614 (January 2017): 87-98.

PMID
28500598
Full Text

Crowley, SD, and Jeffs, AD. "Targeting cytokine signaling in salt-sensitive hypertension." American journal of physiology. Renal physiology 311, no. 6 (December 2016): F1153-F1158. (Review)

PMID
27558557
Full Text

Rudemiller, NP, Patel, MB, Zhang, J-D, Jeffs, AD, Karlovich, NS, Griffiths, R, Kan, MJ, Buckley, AF, Gunn, MD, and Crowley, SD. "C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration." The American journal of pathology 186, no. 11 (November 2016): 2846-2856.

PMID
27640148
Full Text

Zhang, J, Rudemiller, NP, Patel, MB, Wei, Q, Karlovich, NS, Jeffs, AD, Wu, M, Sparks, MA, Privratsky, JR, Herrera, M, Gurley, SB, Nedospasov, SA, and Crowley, SD. "Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI." Journal of the American Society of Nephrology : JASN 27, no. 8 (August 2016): 2257-2264.

PMID
26744488
Full Text

Rudemiller, NP, and Crowley, SD. "Interactions Between the Immune and the Renin-Angiotensin Systems in Hypertension." Hypertension (Dallas, Tex. : 1979) 68, no. 2 (August 2016): 289-296.

PMID
27354427
Full Text

Madan, B, Patel, MB, Zhang, J, Bunte, RM, Rudemiller, NP, Griffiths, R, Virshup, DM, and Crowley, SD. "Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis." Kidney international 89, no. 5 (May 2016): 1062-1074.

PMID
27083283
Full Text

Pages