Nephrology

Steven Daniel Crowley, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address steven.d.crowley@duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Grants

Publications

Ren, Jiafa, Jiandong Zhang, Nathan P. Rudemiller, Robert Griffiths, Yi Wen, Xiaohan Lu, Jamie R. Privratsky, Michael D. Gunn, and Steven D. Crowley. “Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation..” J Am Soc Nephrol 30, no. 9 (September 2019): 1674–85. https://doi.org/10.1681/ASN.2018121253.

PMID
31315922
Full Text

Yang, Bo, Lili Fu, Jamie R. Privratsky, Xiaohan Lu, Jiafa Ren, Changlin Mei, and Steven D. Crowley. “Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis..” Am J Physiol Renal Physiol 317, no. 2 (August 1, 2019): F221–28. https://doi.org/10.1152/ajprenal.00104.2019.

PMID
31141402
Full Text

Wen, Yi, Xiaohan Lu, Jiafa Ren, Jamie R. Privratsky, Bo Yang, Nathan P. Rudemiller, Jiandong Zhang, et al. “KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis..” J Am Soc Nephrol, July 23, 2019. https://doi.org/10.1681/ASN.2019020111.

PMID
31337692
Full Text

Lerman, Lilach O., Theodore W. Kurtz, Rhian M. Touyz, David H. Ellison, Alejandro R. Chade, Steven D. Crowley, David L. Mattson, et al. “Animal Models of Hypertension: A Scientific Statement From the American Heart Association..” Hypertension 73, no. 6 (June 2019): e87–120. https://doi.org/10.1161/HYP.0000000000000090.

PMID
30866654
Full Text

Wen, Yi, Nathan P. Rudemiller, Jiandong Zhang, Alexander D. Jeffs, Robert Griffiths, Xiaohan Lu, Jiafa Ren, Jamie Privratsky, and Steven D. Crowley. “Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis..” Am J Pathol 189, no. 5 (May 2019): 981–88. https://doi.org/10.1016/j.ajpath.2019.02.004.

PMID
31000207
Full Text

Privratsky, Jamie R., Nian Wang, Yi Qi, Jiafa Ren, Benjamin T. Morris, John C. Hunting, G Allan Johnson, and Steven D. Crowley. “Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury..” Am J Physiol Renal Physiol 316, no. 2 (February 1, 2019): F351–59. https://doi.org/10.1152/ajprenal.00416.2018.

PMID
30516426
Full Text

Li, Zuo-Lin, Lin-Li Lv, Tao-Tao Tang, Bin Wang, Ye Feng, Le-Ting Zhou, Jing-Yuan Cao, et al. “HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation..” Kidney Int 95, no. 2 (February 2019): 388–404. https://doi.org/10.1016/j.kint.2018.09.013.

PMID
30551896
Full Text

Tang, Tao-Tao, Lin-Li Lv, Bin Wang, Jing-Yuan Cao, Ye Feng, Zuo-Lin Li, Min Wu, et al. “Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis..” Theranostics 9, no. 16 (2019): 4740–55. https://doi.org/10.7150/thno.33520.

PMID
31367254
Full Text

Pages