Nephrology

Steven Daniel Crowley, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 2nd Floor, Room 2018, MSRB II, 106 Research Drive, Durham, NC 27710
Phone (919) 684-9788
Email address steven.d.crowley@duke.edu

Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2001 - 2003
  • Chief Medical Resident, Medicine, Duke University, 2000 - 2001
  • Fellow in Nephrology, Medicine, Duke University, 1999 - 2000
  • Medical Resident, Medicine, Duke University, 1996 - 1999
  • M.D., Duke University, 1996

Grants

Publications

Lu, Xiaohan, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P. Rudemiller, Shintaro Ide, Tomokazu Souma, and Steven D. Crowley. “Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation.” Hypertension 79, no. 6 (June 2022): 1227–36. https://doi.org/10.1161/HYPERTENSIONAHA.121.18734.

PMID
35430875
Full Text

Ren, Jiafa, Xiaohan Lu, Gentzon Hall, Jamie R. Privratsky, Matthew J. Robson, Randy D. Blakely, and Steven D. Crowley. “IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.” Am J Physiol Renal Physiol 322, no. 2 (February 1, 2022): F164–74. https://doi.org/10.1152/ajprenal.00353.2021.

PMID
34894725
Full Text

Li, Zuo-Lin, Bin Wang, Lin-Li Lv, Tao-Tao Tang, Yi Wen, Jing-Yuan Cao, Xiao-Xiao Zhu, Song-Tao Feng, Steven D. Crowley, and Bi-Cheng Liu. “FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.” Acta Pharmacol Sin 42, no. 12 (December 2021): 2106–19. https://doi.org/10.1038/s41401-021-00617-4.

PMID
33658705
Full Text

Lu, Xiaohan, Jiafa Ren, Robert Griffiths, Gianna Hammer, Ting Yang, and Steven D. Crowley. “Abstract MP31: A20 In Renal Tubular Cells Protects Against Hypertension.” In Hypertension, Vol. 78. Ovid Technologies (Wolters Kluwer Health), 2021. https://doi.org/10.1161/hyp.78.suppl_1.mp31.

Full Text

Ren, Jiafa, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, and Steven D. Crowley. “Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.148109.

PMID
34369383
Full Text

Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah A. Strausser, Koki Abe, Savannah Herbek, Lori L. O’Brien, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.” Elife 10 (July 19, 2021). https://doi.org/10.7554/eLife.68603.

PMID
34279220
Full Text

Ren, Jiafa, Xiaohan Lu, Robert Griffiths, Jamie R. Privratsky, and Steven D. Crowley. “Twist1 in T Lymphocytes Augments Kidney Fibrosis after Ureteral Obstruction.” Kidney360 2, no. 5 (May 27, 2021): 784–94. https://doi.org/10.34067/KID.0007182020.

PMID
35373065
Full Text

Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah Strausser, Savannah Herbek, Lori O’Brien, Steven Crowley, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair,” March 23, 2021. https://doi.org/10.1101/2021.03.23.436661.

Full Text

Sparks, Matthew A., Fitra Rianto, Edward Diaz, Ritika Revoori, Thien Hoang, Lucas Bouknight, Johannes Stegbauer, et al. “Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.” Hypertension 77, no. 2 (February 2021): 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079.

PMID
33390039
Full Text

Pages