Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Pirsch, J. D., M. Kalayoglu, A. M. D’Alessandro, M. J. Armbrust, A. Reed, S. J. Knechtle, H. W. Sollinger, and F. O. Belzer. “Orthotopic liver transplantation in patients over 60 years of age.” Transplant Proc 23, no. 1 Pt 2 (February 1991): 1456–57.

PMID
1989263
Scholars@Duke

D’Alessandro, A. M., M. Kalayoglu, H. W. Sollinger, R. M. Hoffmann, A. Reed, S. J. Knechtle, J. D. Pirsch, G. R. Hafez, D. Lorentzen, and F. O. Belzer. “The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.” Transplant Proc 23, no. 1 Pt 2 (February 1991): 1536–37.

PMID
1989280
Scholars@Duke

Reed, A., J. D. Pirsch, M. J. Armbrust, W. J. Burlingham, S. J. Knechtle, A. M. D’Alessandro, H. W. Sollinger, M. Kalayoglu, and F. O. Belzer. “A comparison of donor-specific and random transfusions in living-related renal transplantation and their effect on steroid withdrawal.” Transplant Proc 23, no. 1 Pt 2 (February 1991): 1321–22.

PMID
1989226
Scholars@Duke

Pirsch, J. D., M. Kalayoglu, A. M. D’Alessandro, M. J. Armbrust, A. Reed, S. J. Knechtle, H. W. Sollinger, and F. O. Belzer. “Orthotopic liver transplantation in patients over 60 years of age.” In Transplantation Proceedings, 23:1456–57, 1991.

Scholars@Duke

Pirsch, J. D., M. J. Armbrust, S. J. Knechtle, A. Reed, A. M. D’Alessandro, H. W. Sollinger, and F. O. Belzer. “Effect of steroid withdrawal on hypertension and cholesterol levels in living related recipients.” In Transplantation Proceedings, 23:1363–64, 1991.

Scholars@Duke

Reed, A., H. W. Sollinger, S. J. Knechtle, A. M. D’Alessandro, M. Kalayoglu, J. D. Pirsch, and F. O. Belzer. “Ruptured splenic artery aneurysm: An unusual late complication following pancreas transplantation.” Clinical Transplantation 5, no. 4 (January 1, 1991): 327–29.

Scholars@Duke

Reed, A., J. D. Pirsch, M. J. Armbrust, W. J. Burlingham, S. J. Knechtle, A. M. D’Alessandro, H. W. Sollinger, M. Kalayoglu, and F. O. Belzer. “A comparison of donor-specific and random transfusions in living-related renal transplantation and their effect on steroid withdrawal.” In Transplantation Proceedings, 23:1321–22, 1991.

Scholars@Duke

Knechtle, S. J., J. D. Pirsch, M. Groshek, A. Reed, A. M. D’Alessandro, M. Kalayoglu, F. O. Belzer, and H. W. Sollinger. “OKT3 vs ALG induction therapy in combined pancreas-kidney transplantation.” In Transplantation Proceedings, 23:1581–82, 1991.

Scholars@Duke

D’Alessandro, A. M., M. Kalayoglu, H. W. Sollinger, R. M. Hoffmann, A. Reed, S. J. Knechtle, J. D. Pirsch, G. R. Hafez, D. Lorentzen, and F. O. Belzer. “The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.” In Transplantation Proceedings, 23:1536–37, 1991.

Scholars@Duke

D’Alessandro, A. M., M. Kalayoglu, H. W. Sollinger, R. M. Hoffmann, A. Reed, S. J. Knechtle, J. D. Pirsch, G. R. Hafez, D. Lorentzen, and F. O. Belzer. “The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation.” Transplantation 51, no. 1 (January 1991): 157–63. https://doi.org/10.1097/00007890-199101000-00024.

PMID
1987685
Full Text

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