Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 3126, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Sci Signal 4, no. 185 (August 9, 2011): ra51-.

PMID
21868357
Full Text

Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends Mol Med 17, no. 3 (March 2011): 126-139. (Review)

PMID
21183406
Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)." Proc Natl Acad Sci U S A 107, no. 34 (August 24, 2010): 15299-15304.

PMID
20686112
Full Text

Rajagopal, S, Rajagopal, K, and Lefkowitz, RJ. "Teaching old receptors new tricks: biasing seven-transmembrane receptors." Nat Rev Drug Discov 9, no. 5 (May 2010): 373-386. (Review)

PMID
20431569
Full Text

Rajagopal, S, Kim, J, Ahn, S, Craig, S, Lam, CM, Gerard, NP, Gerard, C, and Lefkowitz, RJ. "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7." Proc Natl Acad Sci U S A 107, no. 2 (January 12, 2010): 628-632.

PMID
20018651
Full Text

Rajagopal, S, and Kent, SBH. "Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit." Protein science : a publication of the Protein Society 16, no. 9 (September 2007): 2056-2064.

PMID
17660260
Full Text

Ihee, H, Rajagopal, S, Srajer, V, Pahl, R, Anderson, S, Schmidt, M, Schotte, F, Anfinrud, PA, Wulff, M, and Moffat, K. "Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds." Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 3, 2005): 7145-7150.

PMID
15870207
Full Text

Rajagopal, S, Anderson, S, Srajer, V, Schmidt, M, Pahl, R, and Moffat, K. "A structural pathway for signaling in the E46Q mutant of photoactive yellow protein." Structure (London, England : 1993) 13, no. 1 (January 2005): 55-63.

PMID
15642261
Full Text

Rajagopal, S, Key, JM, Purcell, EB, Boerema, DJ, and Moffat, K. "Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli." Photochemistry and Photobiology 80, no. 3 (November 1, 2004): 542-547.

Full Text

Rajagopal, S, Key, JM, Purcell, EB, Boerema, DJ, and Moffat, K. "Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli." Photochemistry and photobiology 80, no. 3 (November 2004): 542-547.

PMID
15453820
Full Text

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