Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 102147, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Onaran, H Ongun, Sudarshan Rajagopal, and Tommaso Costa. “What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling..” Trends Pharmacol Sci 35, no. 12 (December 2014): 639–47. https://doi.org/10.1016/j.tips.2014.09.010.

PMID
25448316
Full Text

Rajagopal, Sudarshan, Daniel E. Forsha, Niels Risum, Christoph P. Hornik, Abby D. Poms, Terry A. Fortin, Victor F. Tapson, Eric J. Velazquez, Joseph Kisslo, and Zainab Samad. “Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views..” J Am Soc Echocardiogr 27, no. 6 (June 2014): 657-665.e3. https://doi.org/10.1016/j.echo.2014.02.001.

PMID
24656881
Full Text

Forsha, Daniel, Niels Risum, P Andrea Kropf, Sudarshan Rajagopal, P Brian Smith, Ronald J. Kanter, Zainab Samad, Peter Sogaard, Piers Barker, and Joseph Kisslo. “Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population..” J Am Soc Echocardiogr 27, no. 4 (April 2014): 413–22. https://doi.org/10.1016/j.echo.2013.12.018.

PMID
24508364
Full Text

Kahsai, Alem W., Sudarshan Rajagopal, Jinpeng Sun, and Kunhong Xiao. “Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry..” Nat Protoc 9, no. 6 (2014): 1301–19. https://doi.org/10.1038/nprot.2014.075.

PMID
24810039
Full Text

Rajagopal, Sudarshan, Daniel L. Bassoni, James J. Campbell, Norma P. Gerard, Craig Gerard, and Tom S. Wehrman. “Biased agonism as a mechanism for differential signaling by chemokine receptors..” J Biol Chem 288, no. 49 (December 6, 2013): 35039–48. https://doi.org/10.1074/jbc.M113.479113.

PMID
24145037
Full Text

Rajagopal, Sudarshan. “Quantifying biased agonism: understanding the links between affinity and efficacy..” Nat Rev Drug Discov 12, no. 6 (June 2013). https://doi.org/10.1038/nrd3954-c1.

PMID
23681006
Full Text

Xiao, K., J. Sun, J. Kim, S. Rajagopal, B. Zhai, J. Villén, W. Haas, et al. “Erratum: Global phosphorylation analysis of ß-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107).” Proceedings of the National Academy of Sciences of the United States of America 109, no. 33 (August 14, 2012). https://doi.org/10.1073/pnas.1211889109.

Full Text

Rajagopal, Sudarshan, Seungkirl Ahn, David H. Rominger, William Gowen-MacDonald, Christopher M. Lam, Scott M. Dewire, Jonathan D. Violin, and Robert J. Lefkowitz. “Quantifying ligand bias at seven-transmembrane receptors..” Mol Pharmacol 80, no. 3 (September 2011): 367–77. https://doi.org/10.1124/mol.111.072801.

PMID
21610196
Full Text

Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor..” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.

PMID
21857662
Full Text

Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1..” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.

PMID
21857681
Full Text

Pages