Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 3126, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Rajagopal, S, Bassoni, DL, Campbell, JJ, Gerard, NP, Gerard, C, and Wehrman, TS. "Biased agonism as a mechanism for differential signaling by chemokine receptors." The Journal of Biological Chemistry 288, no. 49 (December 2013): 35039-35048.

PMID
24145037
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Rajagopal, S. "Quantifying biased agonism: understanding the links between affinity and efficacy." Nature Reviews. Drug Discovery 12, no. 6 (June 2013): 483-null. (Letter)

PMID
23681006
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Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)." Proceedings of the National Academy of Sciences of the United States of America 109, no. 33 (2012): 13464--.

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Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Molecular Pharmacology 80, no. 3 (September 2011): 367-377.

PMID
21610196
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Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor." Nature Chemical Biology 7, no. 10 (August 21, 2011): 692-700.

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21857662
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Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1." Nature 477, no. 7364 (August 21, 2011): 349-353.

PMID
21857681
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Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Science Signaling 4, no. 185 (August 2011): ra51-null.

PMID
21868357
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Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends in Molecular Medicine 17, no. 3 (March 2011): 126-139. (Review)

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21183406
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Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)." Proceedings of the National Academy of Sciences of the United States of America 107, no. 34 (August 4, 2010): 15299-15304.

PMID
20686112
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Rajagopal, S, Rajagopal, K, and Lefkowitz, RJ. "Teaching old receptors new tricks: biasing seven-transmembrane receptors." Nature Reviews. Drug Discovery 9, no. 5 (May 2010): 373-386. (Review)

PMID
20431569
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