Rheumatology and Immunology

Teresa Kathleen Tarrant, MD

Instructor in the Department of Medicine
Campus mail 10207 Cerny St., Ste #200B, Duke Rheumatology Clinic At Brier Creek, Raleigh, NC 27617
Phone (919) 684-4499
Email address teresa.tarrant@duke.edu

I first became interested in clinical immunology as a medical student studying autoimmune inflammatory eye disease at the National Institutes of Health.  Since then, I have been inspired to understand what causes autoimmunity and immune deficiency disorders in order to improve the quality of life for my patients.  I see patients with multiple complex immune disorders with particular expertise in autoimmune and Rheumatoid arthritis, primary Sjogren's syndrome, and Common Variable Immunodeficiency (CVID). My research investigates immune targets that may impact either the development of immune disease or identify new therapies for patients.  The goal is to help us understand why and how immunologic diseases develop so that we may better treat them.

Education and Training

  • Immunology Postdoctoral Fellowship, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 2004 - 2005
  • Allergy and Immunology Fellowship, Medicine, Duke University School of Medicine, 2002 - 2005
  • Rheumatology Fellowship, Medicine, Duke University School of Medicine, 2001 - 2005
  • Internal Medicine Residency, Clinical Investigator Pathway, Duke University School of Medicine, 1999 - 2001
  • M.D., University of Florida College of Medicine, 1999

Grants

Publications

Kang, S, Rogers, JL, Monteith, AJ, Jiang, C, Schmitz, J, Clarke, SH, Tarrant, TK, Truong, YK, Diaz, M, Fedoriw, Y, and Vilen, BJ. "Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus." Journal of immunology (Baltimore, Md. : 1950) 196, no. 10 (May 2016): 4030-4039.

PMID
27059595
Full Text

Yang, L, Shah, SN, Serafin, DS, Timoshchenko, RG, Scotland, P, Richards, K, Billard, MJ, Lugar, PL, and Tarrant, TK. "Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity." February 2016.

Full Text

Tarrant, TK, Billard, MJ, Timoshchenko, RG, McGinnis, MW, Stephen Serafin, D, Foreman, O, Esserman, DA, Chao, NJ, Lento, WE, Lee, DM, Patel, D, and Siderovski, DP. "G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses." Journal of Leukocyte Biology 94, no. 6 (December 1, 2013): 1243-1251.

PMID
23935208
Full Text

Rothlein, LR, Shaheen, AW, Vavalle, JP, Smith, SV, Renner, JB, Shaheen, NJ, and Tarrant, TK. "Sclerosing mesenteritis successfully treated with a TNF antagonist." Case Reports 2010, no. dec17 1 (December 20, 2010): bcr0720103145-bcr0720103145.

Full Text

Tarrant, TK, Rampersad, RR, Esserman, D, Rothlein, LR, Liu, P, Premont, RT, Lefkowitz, RJ, Lee, DM, and Patel, DD. "Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)." Clin Immunol 129, no. 1 (October 2008): 115-122.

PMID
18662895
Full Text

Graziewicz, MA, Tarrant, TK, Buckley, B, Roberts, J, Fulton, L, Hansen, H, Ørum, H, Kole, R, and Sazani, P. "An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models." Molecular therapy : the journal of the American Society of Gene Therapy 16, no. 7 (July 2008): 1316-1322.

PMID
18461057
Full Text

Tarrant, T, Rampersad, R, Moore, C, Rothlein, L, Lefkowitz, R, Lee, D, and Patel, D. "G-Protein Receptor Kinases (grKs) Play an Important Regulatory Role in the K/BxN Serum Transfer Model of Inflammatory Arthritis." January 2007.

Full Text

Tarrant, TK, Rampersad, RR, Moore, CG, Rothlein, LR, Lefkowitz, RM, Lee, DM, and Patel, DD. "G-protein receptor kinases (GRKs) play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis." January 2007.

Full Text

Tarrant, TK, Rampersad, RR, Lefkowitz, RK, Lee, DM, and Patel, DD. "Beta-arrestin2 and G-protein receptor kinases play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis." September 2005.

Scholars@Duke

Xu, H, Silver, PB, Tarrant, TK, Chan, C-C, and Caspi, RR. "Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells." Investigative ophthalmology & visual science 44, no. 11 (November 2003): 4805-4812.

PMID
14578402
Full Text

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