Endocrinology, Metabolism, and Nutrition

Thomas Charles Becker, PhD

Assistant Professor in Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail Duke Box 3813, Durham, NC 27710
Phone (919) 479-2367
Email address thomas.becker@duke.edu

Education and Training

  • Ph.D., University of Texas at Dallas, 1997

Grants

Publications

Khan, Md Wasim, Medha Priyadarshini, Jose Cordoba-Chacon, Thomas C. Becker, and Brian T. Layden. “Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.” Biochim Biophys Acta Mol Basis Dis 1865, no. 3 (March 1, 2019): 678–87. https://doi.org/10.1016/j.bbadis.2018.11.022.

PMID
30543855
Full Text

Haldeman, Jonathan M., Amanda E. Conway, Michelle E. Arlotto, Dorothy H. Slentz, Deborah M. Muoio, Thomas C. Becker, and Christopher B. Newgard. “Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.” Nucleic Acids Res 47, no. 4 (February 28, 2019): e23. https://doi.org/10.1093/nar/gky1286.

PMID
30590691
Full Text

Pusec, Carolina M., Adam De Jesus, Md Wasim Khan, Alexander R. Terry, Anton E. Ludvik, Kai Xu, Nicholas Giancola, et al. “Hepatic HKDC1 Expression Contributes to Liver Metabolism.” Endocrinology 160, no. 2 (February 1, 2019): 313–30. https://doi.org/10.1210/en.2018-00887.

PMID
30517626
Full Text

Oh, Eunjin, Miwon Ahn, Solomon Afelik, Thomas C. Becker, Bart O. Roep, and Debbie C. Thurmond. “Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.” Diabetes 67, no. 12 (December 2018): 2626–39. https://doi.org/10.2337/db18-0259.

PMID
30305365
Full Text

Wang, Huan, Aaron Bender, Peng Wang, Esra Karakose, William B. Inabnet, Steven K. Libutti, Andrew Arnold, et al. “Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.” Nat Commun 8, no. 1 (October 3, 2017): 767. https://doi.org/10.1038/s41467-017-00992-9.

PMID
28974674
Full Text

Hayes, Heather L., Lu Zhang, Thomas C. Becker, Jonathan M. Haldeman, Samuel B. Stephens, Michelle Arlotto, Larry G. Moss, Christopher B. Newgard, and Hans E. Hohmeier. “A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.” Mol Cell Biol 36, no. 23 (December 1, 2016): 2918–30. https://doi.org/10.1128/MCB.00103-16.

PMID
27620967
Full Text

Rosario, Wilfredo, Inderroop Singh, Arnaud Wautlet, Christa Patterson, Jonathan Flak, Thomas C. Becker, Almas Ali, et al. “The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.” Diabetes 65, no. 9 (September 2016): 2711–23. https://doi.org/10.2337/db15-0629.

PMID
27207534
Full Text

Marzban, L., A. Tomas, T. C. Becker, L. Rosenberg, J. Oberholzer, P. E. Fraser, P. A. Halban, and C. B. Verchere. “Erratum: Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture (Diabetes (2008) 57 (3045-3055)).” Diabetes 65, no. 3 (March 1, 2016). https://doi.org/10.2337/db16-er03.

Full Text

Guo, Cong, Anton E. Ludvik, Michelle E. Arlotto, M Geoffrey Hayes, Loren L. Armstrong, Denise M. Scholtens, Christopher D. Brown, et al. “Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.” Nat Commun 6 (February 4, 2015): 6069. https://doi.org/10.1038/ncomms7069.

PMID
25648650
Full Text

Hobson, Amanda, Carrie Draney, Andrew Stratford, Thomas C. Becker, Danhong Lu, Michelle Arlotto, and Jeffery S. Tessem. “Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.” Islets 7, no. 1 (2015): e1027854. https://doi.org/10.1080/19382014.2015.1027854.

PMID
26030060
Full Text

Pages