Thomas Charles Becker, PhD

Publications

Ronnebaum, SM, Ilkayeva, O, Burgess, SC, Joseph, JW, Lu, D, Stevens, RD, Becker, TC, Sherry, AD, Newgard, CB, and Jensen, MV. "A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 41 (October 2006): 30593-30602.

PMID
16912049
Full Text

Jensen, Mette V., Jamie W. Joseph, Olga Ilkayeva, Shawn Burgess, Danhong Lu, Sarah M. Ronnebaum, Matthew Odegaard, Thomas C. Becker, A Dean Sherry, and Christopher B. Newgard. “Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion..” J Biol Chem 281, no. 31 (August 4, 2006): 22342–51. https://doi.org/10.1074/jbc.M604350200.

PMID
16740637
Full Text

Cao, Wenhong, Qu Fan Collins, Thomas C. Becker, Jacques Robidoux, Edgar G. Lupo, Yan Xiong, Kiefer W. Daniel, Lisa Floering, and Sheila Collins. “p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis..” J Biol Chem 280, no. 52 (December 30, 2005): 42731–37. https://doi.org/10.1074/jbc.M506223200.

PMID
16272151
Full Text

Schisler, Jonathan C., Per Bo Jensen, David G. Taylor, Thomas C. Becker, Filip Krag Knop, Shiro Takekawa, Michael German, et al. “The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells..” Proc Natl Acad Sci U S A 102, no. 20 (May 17, 2005): 7297–7302. https://doi.org/10.1073/pnas.0502168102.

PMID
15883383
Full Text

Iype, Tessy, Joshua Francis, James C. Garmey, Jonathan C. Schisler, Rafael Nesher, Gordon C. Weir, Thomas C. Becker, Christopher B. Newgard, Steven C. Griffen, and Raghavendra G. Mirmira. “Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes..” J Biol Chem 280, no. 17 (April 29, 2005): 16798–807. https://doi.org/10.1074/jbc.M414381200.

PMID
15743769
Full Text

Bain, James R., Jonathan C. Schisler, Koji Takeuchi, Christopher B. Newgard, and Thomas C. Becker. “An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans..” Diabetes 53, no. 9 (September 2004): 2190–94. https://doi.org/10.2337/diabetes.53.9.2190.

PMID
15331526
Full Text

Newgard, C. B., T. C. Becker, H. K. Berman, and R. M. O’Doherty. “Regulation of overexpressed hexokinases in liver and islet cells..” Biochemical Society Transactions 25, no. 1 (February 1997): 118–22. https://doi.org/10.1042/bst0250118.

PMID
9056855
Full Text

Becker, T. C., R. J. Noel, J. H. Johnson, R. M. Lynch, H. Hirose, Y. Tokuyama, G. I. Bell, and C. B. Newgard. “Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes..” J Biol Chem 271, no. 1 (January 5, 1996): 390–94. https://doi.org/10.1074/jbc.271.1.390.

PMID
8550593
Full Text

Argaud, D., A. J. Lange, T. C. Becker, D. A. Okar, M. R. el-Maghrabi, C. B. Newgard, and S. J. Pilkis. “Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels..” J Biol Chem 270, no. 41 (October 13, 1995): 24229–36. https://doi.org/10.1074/jbc.270.41.24229.

PMID
7592629
Full Text

Becker, T. C., H. BeltrandelRio, R. J. Noel, J. H. Johnson, and C. B. Newgard. “Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels..” The Journal of Biological Chemistry 269, no. 33 (August 1994): 21234–38.

PMID
8063745
Scholars@Duke

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