Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Tyson, CC, and Coffman, TM. "In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?." Nephron 135, no. 4 (January 2017): 287-290.

PMID
28161697
Full Text

Tinning, AR, Jensen, BL, Johnsen, I, Chen, D, Coffman, TM, and Madsen, K. "Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development." American journal of physiology. Renal physiology 311, no. 3 (September 2016): F586-F599.

PMID
27413199
Full Text

Chen, D, Stegbauer, J, Sparks, MA, Kohan, D, Griffiths, R, Herrera, M, Gurley, SB, and Coffman, TM. "Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension." Hypertension (Dallas, Tex. : 1979) 67, no. 6 (June 2016): 1291-1297.

PMID
27141055
Full Text

Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Griffiths, RC, Azad, HA, Herrera, M, Gurley, SB, and Coffman, TM. "Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion." Journal of the American Society of Nephrology : JASN 26, no. 12 (December 2015): 2953-2962.

PMID
25855778
Full Text

Stegbauer, J, and Coffman, TM. "Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin." Journal of Clinical Investigation 125, no. 11 (November 2015): 4008-4010.

PMID
26495835
Full Text

Dimke, H, Sparks, MA, Thomson, BR, Frische, S, Coffman, TM, and Quaggin, SE. "Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney." Journal of the American Society of Nephrology : JASN 26, no. 5 (May 2015): 1027-1038.

PMID
25385849
Full Text

Yang, Y, Gomez, JA, Herrera, M, Perez-Marco, R, Repenning, P, Zhang, Z, Payne, A, Pratt, RE, Koller, B, Beierwaltes, WH, Coffman, T, Mirotsou, M, and Dzau, VJ. "Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4." Hypertension (Dallas, Tex. : 1979) 65, no. 5 (May 2015): 1047-1054.

PMID
25776075
Full Text

Young, CN, Morgan, DA, Butler, SD, Rahmouni, K, Gurley, SB, Coffman, TM, Mark, AL, and Davisson, RL. "Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis." Molecular metabolism 4, no. 4 (April 2015): 337-343.

PMID
25830096
Full Text

Chen, D, and Coffman, TM. "AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation." Current opinion in pharmacology 21 (April 2015): 122-126. (Review)

PMID
25687370
Full Text

Young, CN, Morgan, DA, Butler, SD, Rahmouni, K, Gurley, SB, Coffman, TM, Mark, AL, and Davisson, RL. "Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis." Molecular Metabolism 4, no. 4 (January 1, 2015): 337-343.

Full Text

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