Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Lerman, Lilach O., Theodore W. Kurtz, Rhian M. Touyz, David H. Ellison, Alejandro R. Chade, Steven D. Crowley, David L. Mattson, et al. “Animal Models of Hypertension: A Scientific Statement From the American Heart Association..” Hypertension 73, no. 6 (June 2019): e87–120. https://doi.org/10.1161/HYP.0000000000000090.

PMID
30866654
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Sabanayagam, Charumathi, Miao Li Chee, Riswana Banu, Ching-Yu Cheng, Su Chi Lim, E Shyong Tai, Thomas Coffman, and Tien Y. Wong. “Association of Diabetic Retinopathy and Diabetic Kidney Disease With All-Cause and Cardiovascular Mortality in a Multiethnic Asian Population..” Jama Netw Open 2, no. 3 (March 1, 2019). https://doi.org/10.1001/jamanetworkopen.2019.1540.

PMID
30924904
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Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension..” J Am Heart Assoc 8, no. 4 (February 19, 2019). https://doi.org/10.1161/JAHA.118.010745.

PMID
30764697
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Gurley, Susan B., Sujoy Ghosh, Stacy A. Johnson, Kengo Azushima, Rashidah Binte Sakban, Simi E. George, Momoe Maeda, Timothy W. Meyer, and Thomas M. Coffman. “Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy..” Diabetes 67, no. 10 (October 2018): 2096–2106. https://doi.org/10.2337/db17-1323.

PMID
30065034
Full Text

Stegbauer, Johannes, Daian Chen, Marcela Herrera, Matthew A. Sparks, Ting Yang, Eva Königshausen, Susan B. Gurley, and Thomas M. Coffman. “Resistance to hypertension mediated by intercalated cells of the collecting duct..” Jci Insight 2, no. 7 (April 6, 2017). https://doi.org/10.1172/jci.insight.92720.

PMID
28405625
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Tyson, Crystal C., and Thomas M. Coffman. “In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?.” Nephron 135, no. 4 (2017): 287–90. https://doi.org/10.1159/000455130.

PMID
28161697
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Tinning, Anne R., Boye L. Jensen, Iben Johnsen, Daian Chen, Thomas M. Coffman, and Kirsten Madsen. “Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development..” Am J Physiol Renal Physiol 311, no. 3 (September 1, 2016): F586–99. https://doi.org/10.1152/ajprenal.00221.2016.

PMID
27413199
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Paradis, Pierre, Marie Briet, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Suellen C. Coelho, Yohann Rautureau, Thomas M. Coffman, and Ernesto L. Schiffrin. “PS 07-16 CROSSTALK BETWEEN ALDOSTERONE-STIMULATED MINERALOCORTICOID RECEPTOR AND ANGIOTENSIN RECEPTOR PATHWAYS PLAYS A ROLE IN ALDOSTERONE-INDUCED VASCULAR INJURY.” In Journal of Hypertension, 34:e287–88. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1097/01.hjh.0000500680.24040.e2.

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