Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Smith, SR, Creech, EA, Schaffer, AV, Martin, LL, Rakhit, A, Douglas, FL, Klotman, PE, and Coffman, TM. "Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity." Kidney Int 41, no. 1 (January 1992): 199-205.

PMID
1593856
Scholars@Duke

Ruiz, P, Rey, L, Spurney, R, Coffman, T, and Viciana, A. "Thromboxane augmentation of alloreactive T cell function." Transplantation 54, no. 3 (1992): 498-505.

PMID
1412730
Scholars@Duke

Chouinard, ML, Martin, LL, Coffman, T, Hamilton, BH, Linberg, LF, Pamidi, A, Simke, JP, and Rakhit, A. "Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients." Clinical Pharmacology and Therapeutics 52, no. 6 (1992): 597-604.

PMID
1458769
Scholars@Duke

Spurney, RF, Bernstein, RJ, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Physiologic role for enhanced renal thromboxane production in murine lupus nephritis." Prostaglandins 42, no. 1 (July 1991): 15-28.

PMID
1771236
Full Text

Spurney, RF, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites." Kidney International 39, no. 1 (January 1991): 95-102.

PMID
1848329
Full Text

Himmelstein, SI, Coffman, TM, Yarger, WE, and Klotman, PE. "Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction." The American Journal of Physiology 258, no. 2 Pt 2 (February 1990): F281-F286.

PMID
2137982
Full Text

Spurney, RF, Mayros, SD, Collins, D, Ruiz, P, Klotman, PE, and Coffman, T. "Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats." Prostaglandins 39, no. 2 (February 1990): 135-146.

PMID
2138344
Scholars@Duke

Himmelstein, SI, Coffman, TM, Yarger, WE, and Klotman, PE. "Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 258, no. 2 27-2 (1990): F281-F286.

Scholars@Duke

Collins, DM, Coffman, TM, Ruiz, P, and Klotman, PE. "High-protein feeding stimulates renal thromboxane production in rats with streptozocin-induced diabetes." J Lab Clin Med 114, no. 5 (November 1989): 545-553.

PMID
2809397
Scholars@Duke

Ruiz, P, Coffman, TM, Klotman, PE, and Sanfilippo, F. "Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts." Transplantation 48, no. 4 (October 1989): 660-666.

PMID
2799920
Scholars@Duke

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