Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Coffman, TM, Kolbeck, PC, Sanfilippo, FP, and Klotman, PE. "Renal allograft function, arachidonic acid metabolism, and systemic cellular immunity after kidney transplantation in the rat." Transplantation Proceedings 19, no. 3 (1987): 3116-3118.

Scholars@Duke

Coffman, TM, Sanfilippo, FP, Brazy, PC, Yarger, WE, and Klotman, PE. "Bilateral native nephrectomy improves renal isograft function in rats." Kidney Int 30, no. 1 (July 1986): 20-26.

PMID
3528617
Scholars@Duke

Klotman, PE, Smith, SR, Volpp, BD, Coffman, TM, and Yarger, WE. "Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys." Am J Physiol 250, no. 2 Pt 2 (February 1986): F282-F287.

PMID
3456211
Full Text

Klotman, PE, Smith, SR, Volpp, BD, Coffman, TM, and Yarger, WE. "Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 250, no. 2 (1986): 19/2-.

Scholars@Duke

Coffman, TM, Schwertschlag, U, and Yarger, WE. "Lipid mediators in acute renal allograft rejection." Transplantation Proceedings 18, no. 5 SUPPL. 4 (1986): 94-97.

Scholars@Duke

Coffman, TM, Yarger, WE, and Klotman, PE. "Functional role of thromboxane production by acutely rejecting renal allografts in rats." J Clin Invest 75, no. 4 (April 1985): 1242-1248.

PMID
3886703
Full Text

Mitnick, P, Greenberg, A, Coffman, T, Kelepouris, E, Wolf, CJ, and Goldfarb, S. "Effects of two models of hypercalcemia on renal acid base metabolism." Kidney Int 21, no. 4 (April 1982): 613-620.

PMID
6896540
Scholars@Duke

Mitnick, PD, Greenberg, A, DeOreo, PB, Weiner, BM, Coffman, TM, Walker, BR, Agus, ZS, and Goldfarb, S. "Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney." Clin Pharmacol Ther 28, no. 5 (November 1980): 680-689.

PMID
7002426
Scholars@Duke

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