Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Wang, Z, Chen, S, Asico, LD, Escano, C, Villar, VAM, Lu, Q, Coffman, TM, Jones, JE, Armando, I, Felder, RA, and Jose, PA. "AT1R dysregulation is crucial in the hypertension of human GRK4 gamma A142V transgenic mice.": FEDERATION AMER SOC EXP BIOL, April 1, 2009.

Scholars@Duke

Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." The Journal of Clinical Investigation 119, no. 4 (April 2009): 943-953.

PMID
19287096
Full Text

Benigni, A, Corna, D, Zoja, C, Sonzogni, A, Latini, R, Salio, M, Conti, S, Rottoli, D, Longaretti, L, Cassis, P, Morigi, M, Coffman, TM, and Remuzzi, G. "Disruption of the Ang II type 1 receptor promotes longevity in mice." The Journal of Clinical Investigation 119, no. 3 (March 2009): 524-530.

PMID
19197138
Full Text

Lemarié, CA, Simeone, SMC, Nikonova, A, Ebrahimian, T, Deschênes, M-E, Coffman, TM, Paradis, P, and Schiffrin, EL. "Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors." Circulation Research 105, no. 9 (2009): 852-859.

PMID
19762686
Full Text

Thu H, L, Steven D, C, Susan B, G, and Thomas M, C. "The Renin-Angiotensin System." (December 1, 2008): 343-357. (Chapter)

Full Text

Athirakul, K, Bradbury, JA, Graves, JP, DeGraff, LM, Ma, J, Zhao, Y, Couse, JF, Quigley, R, Harder, DR, Zhao, X, Imig, JD, Pedersen, TL, Newman, JW, Hammock, BD, Conley, AJ, Korach, KS, Coffman, TM, and Zeldin, DC. "Increased blood pressure in mice lacking cytochrome P450 2J5." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 22, no. 12 (December 2008): 4096-4108.

PMID
18716027
Full Text

Spurney, RF, and Coffman, TM. "Stressed-out podocytes in diabetes?." J Am Soc Nephrol 19, no. 11 (November 2008): 2035-2037.

PMID
18842987
Full Text

Crowley, SD, and Coffman, TM. "In hypertension, the kidney breaks your heart." Curr Cardiol Rep 10, no. 6 (November 2008): 470-476. (Review)

PMID
18950556
Scholars@Duke

Crowley, SD, Sprung, G, Griffiths, R, Lin, E, and Coffman, TM. "AT(1) receptors on bone marrow cells modulate kidney injury in hypertension." 13th Annual Meeting of the European-Council-for-Cardiovascular-Research. Nice, FRANCE. October 10, 2008 - October 12, 2008.: LIPPINCOTT WILLIAMS & WILKINS, October 1, 2008.

Scholars@Duke

Francois, H, Makhanova, N, Ruiz, P, Ellison, J, Mao, L, Rockman, HA, and Coffman, TM. "A role for the thromboxane receptor in L-NAME hypertension." American Journal of Physiology Renal Physiology 295, no. 4 (October 2008): F1096-F1102.

PMID
18684890
Full Text

Pages