Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Gembardt, F, Heringer-Walther, S, Esch, JHMV, Sterner-Kock, A, Veghel, RV, Le, TH, Garrelds, IM, Coffman, TM, Danser, AHJ, Schultheiss, H-P, and Walther, T. "Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors." FASEB Journal 22, no. 8 (2008): 3068-3077.

PMID
18497303
Full Text

Ashton, AW, Mukherjee, S, Nagajyothi, FNU, Huang, H, Braunstein, VL, Desruisseaux, MS, Factor, SM, Lopez, L, Berman, JW, Wittner, M, Scherer, PE, Capra, V, Coffman, TM, Serhan, CN, Gotlinger, K, Wu, KK, Weiss, LM, and Tanowitz, HB. "Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection." J Exp Med 204, no. 4 (April 16, 2007): 929-940.

PMID
17420269
Full Text

Parsons, KK, and Coffman, TM. "The renin-angiotensin system: it's all in your head." J Clin Invest 117, no. 4 (April 2007): 873-876.

PMID
17404616
Full Text

Crowley, SD, and Coffman, TM. "In hypertension, the kidney rules." Curr Hypertens Rep 9, no. 2 (April 2007): 148-153. (Review)

PMID
17442227
Scholars@Duke

Gurley, SB, and Coffman, TM. "The renin-angiotensin system and diabetic nephropathy." Semin Nephrol 27, no. 2 (March 2007): 144-152. (Review)

PMID
17418683
Full Text

Quaggin, SE, and Coffman, TM. "Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?." J Am Soc Nephrol 18, no. 2 (February 2007): 364-366.

PMID
17259594
Full Text

Crowley, SD, Gurley, SB, and Coffman, TM. "AT(1) receptors and control of blood pressure: the kidney and more.." Trends Cardiovasc Med 17, no. 1 (January 2007): 30-34. (Review)

PMID
17210476
Full Text

Francois, H, Facemire, C, Kumar, A, Audoly, L, Koller, B, and Coffman, T. "Role of microsomal prostaglandin E synthase 1 in the kidney." Journal of the American Society of Nephrology 18, no. 5 (2007): 1466-1475.

PMID
17442791
Full Text

Crowley, SD, Gurley, SB, Herrera, MJ, Ruiz, P, Griffiths, R, Kumar, AP, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney." Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985-17990.

PMID
17090678
Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.

PMID
17060617
Full Text

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