Thomas Norton Denny

Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Room 4077 MSRB II, Durham, NC 27710
Phone (919) 681-1023
Email address thomas.denny@duke.edu

Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI) and the Center for HIV/AIDS Vaccine Immunology (CHAVI), and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. He has recently been appointed to the Duke University Fuqua School of Business Health Sector Advisory Council. Previously, he was an Associate Professor of Pathology, Laboratory Medicine and Pediatrics, Associate Professor of Preventive Medicine and Community Health and Assistant Dean for Research in Health Policy at the New Jersey Medical School, Newark, New Jersey. He has served on numerous committees for the NIH over the last two decades and currently is the principal investigator of an NIH portfolio in excess of 56 million dollars. Mr. Denny was a 2002-2003 Robert Wood Johnson Foundation Health Policy Fellow at the Institute of Medicine of the National Academies (IOM). As a fellow, he served on the US Senate Health, Education, Labor and Pensions Committee with legislation/policy responsibilities in global AIDS, bioterrorism, clinical trials/human subject protection and vaccine related-issues.

As the Chief Operating Officer of the DHVI, Mr. Denny has administrative oversight of a research portfolio of more than 400 million dollars and has the finance, program management, regulatory/compliance, intellectual property, facilities management, biosafety, human resources and information technology offices as direct reports. He has extensive international experience and previously was a consultant to the U.S. Centers for Disease Control and Prevention (CDC) for the President’s Emergency Plan for AIDS Relief (PEPFAR) project to oversee the development of an HIV and Public Health Center of Excellence laboratory network in Guyana. In September 2004, the IOM appointed him as a consultant to their Board on Global Health Committee studying the options for overseas placement of U.S. health professionals and the development of an assessment plan for activities related to the 2003 PEPFAR legislative act. Previously, Mr. Denny helped establish a small laboratory in the Republic of Kalmykia (former Soviet Union) to improve the care of children with HIV/AIDS. He is also a Board Member of the Children of Chernobyl Relief Fund Foundation. In 2005, Mr. Denny was named a consulting medical/scientific officer to the WHO Global AIDS Program in Geneva. He has also served as program reviewers for the governments of the Netherlands and South Africa as well as an advisor to several U.S. biotech companies. He currently serves as an advisor to Advanced Liquid Logics, Inc., which is headquartered in Durham, North Carolina.

Mr. Denny has authored and co-authored more than 95 peer-reviewed papers and serves on the editorial board of Communications in Cytometry and Journal of Clinical Virology. He holds an M.Sc in Molecular and Biomedical Immunology from the University of East London and a degree in Medical Law (M.Phil) from the Institute of Law and Ethics in Medicine, School of Law, University of Glasgow. In 1991, he completed a course of study in Strategic Management at The Wharton School, University of Pennsylvania. In 1993, he completed the Program for Advanced Training in Biomedical Research Management at Harvard School of Public Health. In December 2005, he was inducted as a Fellow into the College of Physicians of Philadelphia, the oldest medical society in the US.

While living in New Jersey, Mr. Denny was active in his community, gaining additional experience from two publicly elected positions. In 2000, Mr. Denny was selected by the New Jersey League of Municipalities to Chair the New Jersey Community Mental Health Citizens’ Advisory Board and Mental Health Planning Council as a gubernatorial appointment.

Education and Training

  • M.Phil., University of Glasgow (Scotland), 2010
  • M.S., University of East London (Uk), 2001

Publications

Pollara, J, Orlandi, C, Beck, C, Edwards, RW, Hu, Y, Liu, S, Wang, S, Koup, RA, Denny, TN, Lu, S, Tomaras, GD, DeVico, A, Lewis, GK, and Ferrari, G. "Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay." Cytometry. Part A : the journal of the International Society for Analytical Cytology (March 2, 2018).

PMID
29498807
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Bainbridge, J, Rountree, W, Louzao, R, Wong, J, Whitby, L, Denny, TN, and Barnett, D. "Laboratory Accuracy Improvement in the UK NEQAS Leucocyte Immunophenotyping Immune Monitoring Program: An Eleven-Year Review via Longitudinal Mixed Effects Modeling." Cytometry. Part B, Clinical cytometry 94, no. 2 (March 2018): 250-256.

PMID
28480599
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Seaton, KE, Vandergrift, NA, Deal, AW, Rountree, W, Bainbridge, J, Grebe, E, Anderson, DA, Sawant, S, Shen, X, Yates, NL, Denny, TN, Liao, H-X, Haynes, BF, Robb, ML, Parkin, N, Santos, BR, Garrett, N, Price, MA, Naniche, D, Duerr, AC, CEPHIA group, , Keating, S, Hampton, D, Facente, S, Marson, K, Welte, A, Pilcher, CD, Cohen, MS, and Tomaras, GD. "Computational analysis of antibody dynamics identifies recent HIV-1 infection." JCI insight 2, no. 24 (December 21, 2017).

PMID
29263306
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Barbian, HJ, Jackson-Jewett, R, Brown, CS, Bibollet-Ruche, F, Learn, GH, Decker, T, Kreider, EF, Li, Y, Denny, TN, Sharp, PM, Shaw, GM, Lifson, J, Acosta, EP, Saag, MS, Bar, KJ, and Hahn, BH. "Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee." Retrovirology 14, no. 1 (June 2, 2017): 35-.

PMID
28576126
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McKay, HS, Margolick, JB, Martínez-Maza, O, Lopez, J, Phair, J, Rappocciolo, G, Denny, TN, Magpantay, LI, Jacobson, LP, and Bream, JH. "Multiplex assay reliability and long-term intra-individual variation of serologic inflammatory biomarkers." Cytokine 90 (February 2017): 185-192.

PMID
27940218
Full Text

Astronomo, RD, Santra, S, Ballweber-Fleming, L, Westerberg, KG, Mach, L, Hensley-McBain, T, Sutherland, L, Mildenberg, B, Morton, G, Yates, NL, Mize, GJ, Pollara, J, Hladik, F, Ochsenbauer, C, Denny, TN, Warrier, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Ferrari, G, Shaw, GM, Xia, S-M, Liao, H-X, Montefiori, DC, Tomaras, GD, Haynes, BF, and McElrath, JM. "Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection." EBioMedicine 14 (December 2016): 97-111.

PMID
27919754
Full Text

Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." Molecular therapy : the journal of the American Society of Gene Therapy 24, no. 11 (November 2016): 2021-2032.

PMID
27455880
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Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." MOLECULAR THERAPY 24, no. 11 (November 2016): 2021-2032.

Full Text

Hora, B, Gulzar, N, Chen, Y, Cai, F, Su, C, Karagiannis, K, Smith, K, Simonyan, V, Shah, SA, Ahmed, M, Sanchez, AM, Stone, M, Cohen, MS, Haynes, BF, Busch, MP, Mazumder, R, Denny, TN, and Gao, F. "Streamlined quasispecies and subtype analysis of HIV-1 sequences generated by high-throughput sequencing using the high-performance integrated virtual environment (HIVE)." July 2016.

Scholars@Duke

Rountree, W, Berrong, M, Sanchez, AM, Denny, TN, and Ferrari, G. "Variability of the IFN-γ ELISpot assay in the context of proficiency testing and bridging studies." Journal of immunological methods 433 (June 2016): 69-76.

PMID
27021273
Full Text

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