Thomas Norton Denny

Professor in Medicine
Research Professor of Global Health
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Room 4077 MSRB II, Durham, NC 27710
Phone (919) 681-1023
Email address thomas.denny@duke.edu

Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI) and the Center for HIV/AIDS Vaccine Immunology (CHAVI), and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. He has recently been appointed to the Duke University Fuqua School of Business Health Sector Advisory Council. Previously, he was an Associate Professor of Pathology, Laboratory Medicine and Pediatrics, Associate Professor of Preventive Medicine and Community Health and Assistant Dean for Research in Health Policy at the New Jersey Medical School, Newark, New Jersey. He has served on numerous committees for the NIH over the last two decades and currently is the principal investigator of an NIH portfolio in excess of 56 million dollars. Mr. Denny was a 2002-2003 Robert Wood Johnson Foundation Health Policy Fellow at the Institute of Medicine of the National Academies (IOM). As a fellow, he served on the US Senate Health, Education, Labor and Pensions Committee with legislation/policy responsibilities in global AIDS, bioterrorism, clinical trials/human subject protection and vaccine related-issues.

As the Chief Operating Officer of the DHVI, Mr. Denny has administrative oversight of a research portfolio of more than 400 million dollars and has the finance, program management, regulatory/compliance, intellectual property, facilities management, biosafety, human resources and information technology offices as direct reports. He has extensive international experience and previously was a consultant to the U.S. Centers for Disease Control and Prevention (CDC) for the President’s Emergency Plan for AIDS Relief (PEPFAR) project to oversee the development of an HIV and Public Health Center of Excellence laboratory network in Guyana. In September 2004, the IOM appointed him as a consultant to their Board on Global Health Committee studying the options for overseas placement of U.S. health professionals and the development of an assessment plan for activities related to the 2003 PEPFAR legislative act. Previously, Mr. Denny helped establish a small laboratory in the Republic of Kalmykia (former Soviet Union) to improve the care of children with HIV/AIDS. He is also a Board Member of the Children of Chernobyl Relief Fund Foundation. In 2005, Mr. Denny was named a consulting medical/scientific officer to the WHO Global AIDS Program in Geneva. He has also served as program reviewers for the governments of the Netherlands and South Africa as well as an advisor to several U.S. biotech companies. He currently serves as an advisor to Advanced Liquid Logics, Inc., which is headquartered in Durham, North Carolina.

Mr. Denny has authored and co-authored more than 95 peer-reviewed papers and serves on the editorial board of Communications in Cytometry and Journal of Clinical Virology. He holds an M.Sc in Molecular and Biomedical Immunology from the University of East London and a degree in Medical Law (M.Phil) from the Institute of Law and Ethics in Medicine, School of Law, University of Glasgow. In 1991, he completed a course of study in Strategic Management at The Wharton School, University of Pennsylvania. In 1993, he completed the Program for Advanced Training in Biomedical Research Management at Harvard School of Public Health. In December 2005, he was inducted as a Fellow into the College of Physicians of Philadelphia, the oldest medical society in the US.

While living in New Jersey, Mr. Denny was active in his community, gaining additional experience from two publicly elected positions. In 2000, Mr. Denny was selected by the New Jersey League of Municipalities to Chair the New Jersey Community Mental Health Citizens’ Advisory Board and Mental Health Planning Council as a gubernatorial appointment.

Education and Training

  • M.Phil., University of Glasgow (United Kingdom), 2010
  • M.S., University of East London (United Kingdom), 2001

Publications

Jacobs, Jana L., William Bain, Asma Naqvi, Brittany Staines, Priscila M. S. Castanha, Haopu Yang, Valerie F. Boltz, et al. “Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes.” Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 74, no. 9 (May 2022): 1525–33. https://doi.org/10.1093/cid/ciab686.

PMID
34374761
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Whitley, Jill, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, et al. “Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials.” Transl Res 242 (April 2022): 38–55. https://doi.org/10.1016/j.trsl.2021.11.009.

PMID
34871810
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Hurst, Jillian H., Alexander W. McCumber, Jhoanna N. Aquino, Javier Rodriguez, Sarah M. Heston, Debra J. Lugo, Alexandre T. Rotta, et al. “Age-related changes in the nasopharyngeal microbiome are associated with SARS-CoV-2 infection and symptoms among children, adolescents, and young adults.” Clin Infect Dis, March 5, 2022. https://doi.org/10.1093/cid/ciac184.

PMID
35247047
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Stone, Mars, Eduard Grebe, Hasan Sulaeman, Clara Di Germanio, Honey Dave, Kathleen Kelly, Brad J. Biggerstaff, et al. “Evaluation of Commercially Available High-Throughput SARS-CoV-2 Serologic Assays for Serosurveillance and Related Applications.” Emerg Infect Dis 28, no. 3 (March 2022): 672–83. https://doi.org/10.3201/eid2803.211885.

PMID
35202525
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Li, Dapeng, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.” Biorxiv, February 14, 2022. https://doi.org/10.1101/2022.01.26.477915.

PMID
35118474
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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Lilianna Suarez, Carter G. Crew, et al. “Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Clin Infect Dis 73, no. 9 (November 2, 2021): e2875–82. https://doi.org/10.1093/cid/ciaa1693.

PMID
33141180
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.

PMID
34242577
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Yu, Chen, Sejiro Littleton, Nicholas S. Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, et al. “Mucosal-associated invariant T cell responses differ by sex in COVID-19.” Med (N Y) 2, no. 6 (June 11, 2021): 755-772.e5. https://doi.org/10.1016/j.medj.2021.04.008.

PMID
33870241
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Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.

PMID
33971664
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Li, Hui, Shuyi Wang, Fang-Hua Lee, Ryan S. Roark, Alex I. Murphy, Jessica Smith, Chengyan Zhao, et al. “New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure.” J Virol, March 3, 2021. https://doi.org/10.1128/JVI.00071-21.

PMID
33658341
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