Timothy Robert Koves, PhD

Associate Professor in Medicine
Member of Sarah W. Stedman Nutrition & Metabolism Center
Campus mail 300 North Duke Street, 50-202 / Carmichael Bldg, Durham, NC 27701
Phone (919) 479-2324
Email address tim.koves@duke.edu

My research is focused on 1) understanding metabolic perturbations that occur in subpopulations of skeletal muscle mitochondria in response to a chronic high lipid environment, 2) identifying specific metabolites of lipid-induced mitochondrial stress that contribute to skeletal muscle insulin resistance and type II diabetes, and 3) understanding how mitochondrial adaptations in response to exercise confer protection against lipid-induced mitochondrial dysfunction.

Education and Training

  • M.B.A., East Carolina University, 2006
  • Ph.D., East Carolina University, 2002

Publications

Lin, Kevin H., Abigail Xie, Justine C. Rutter, Yeong-Ran Ahn, Julia M. Lloyd-Cowden, Amanda G. Nichols, Ryan S. Soderquist, et al. “Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity..” Cell Metab 29, no. 5 (May 7, 2019): 1217-1231.e7. https://doi.org/10.1016/j.cmet.2019.01.011.

PMID
30773463
Full Text

Khodabukus, Alastair, Lauran Madden, Neel K. Prabhu, Timothy R. Koves, Christopher P. Jackman, Deborah M. Muoio, and Nenad Bursac. “Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle..” Biomaterials 198 (April 2019): 259–69. https://doi.org/10.1016/j.biomaterials.2018.08.058.

PMID
30180985
Full Text

Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics..” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.

PMID
30726738
Full Text

Dai, Qunsheng, Creighton E. Likes, Anthony L. Luz, Lan Mao, Jason S. Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R. Ilkayeva, Timothy R. Koves, and Thomas M. Price. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling..” J Endocr Soc 3, no. 2 (February 1, 2019): 446–67. https://doi.org/10.1210/js.2018-00219.

PMID
30746505
Full Text

Fisher-Wellman, Kelsey H., Michael T. Davidson, Tara M. Narowski, Chien-Te Lin, Timothy R. Koves, and Deborah M. Muoio. “Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes..” Cell Reports 24, no. 13 (September 2018): 3593-3606.e10. https://doi.org/10.1016/j.celrep.2018.08.091.

PMID
30257218
Full Text

Davis, Brittany N. J., Jeffrey W. Santoso, Michaela J. Walker, Cindy S. Cheng, Timothy R. Koves, William E. Kraus, and George A. Truskey. “Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity..” Tissue Eng Part C Methods 23, no. 4 (April 2017): 189–99. https://doi.org/10.1089/ten.tec.2016.0264.

PMID
28338413
Full Text

Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages..” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.

PMID
28154172
Full Text

Huffman, Kim M., Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, et al. “Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability..” Arthritis Res Ther 19, no. 1 (January 23, 2017). https://doi.org/10.1186/s13075-016-1215-7.

PMID
28114971
Full Text

Consitt, Leslie A., Timothy R. Koves, Deborah M. Muoio, Masato Nakazawa, Christopher A. Newton, and Joseph A. Houmard. “Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction..” Biochem Biophys Res Commun 479, no. 4 (October 28, 2016): 868–74. https://doi.org/10.1016/j.bbrc.2016.09.116.

PMID
27693789
Full Text

Williams, Ashley S., Paul A. Grimsrud, Dorothy H. Slentz, April H. Wittmann, Timothy R. Koves, William E. Kraus, and Deborah M. Muoio. “Regulation of Carnitine Acetyltransferase by Lysine Acetylation.” In Diabetes, 65:A15–A15. AMER DIABETES ASSOC, 2016.

Scholars@Duke

Pages