Timothy Robert Koves, PhD

Associate Professor in Medicine
Member of Sarah W. Stedman Nutrition & Metabolism Center
Campus mail 300 North Duke Street, 50-202 / Carmichael Bldg, Durham, NC 27701
Phone (919) 479-2324
Email address tim.koves@duke.edu

My research is focused on 1) understanding metabolic perturbations that occur in subpopulations of skeletal muscle mitochondria in response to a chronic high lipid environment, 2) identifying specific metabolites of lipid-induced mitochondrial stress that contribute to skeletal muscle insulin resistance and type II diabetes, and 3) understanding how mitochondrial adaptations in response to exercise confer protection against lipid-induced mitochondrial dysfunction.

Education and Training

  • M.B.A., East Carolina University, 2006
  • Ph.D., East Carolina University, 2002

Publications

Fisher-Wellman, KH, Davidson, MT, Narowski, TM, Lin, C-T, Koves, TR, and Muoio, DM. "Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes." Cell Reports 24, no. 13 (September 2018): 3593-3606.e10.

PMID
30257218
Full Text

Davis, BNJ, Santoso, JW, Walker, MJ, Cheng, CS, Koves, TR, Kraus, WE, and Truskey, GA. "Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity." Tissue Engineering. Part C, Methods 23, no. 4 (April 2017): 189-199.

PMID
28338413
Full Text

Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of Biological Chemistry 292, no. 11 (March 2017): 4651-4662.

PMID
28154172
Full Text

Huffman, KM, Jessee, R, Andonian, B, Davis, BN, Narowski, R, Huebner, JL, Kraus, VB, McCracken, J, Gilmore, BF, Tune, KN, Campbell, M, Koves, TR, Muoio, DM, Hubal, MJ, and Kraus, WE. "Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability." Arthritis Research & Therapy 19, no. 1 (January 23, 2017): 12-null.

PMID
28114971
Full Text

Consitt, LA, Koves, TR, Muoio, DM, Nakazawa, M, Newton, CA, and Houmard, JA. "Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction." Biochemical and biophysical research communications 479, no. 4 (October 2016): 868-874.

PMID
27693789
Full Text

Aubert, G, Martin, OJ, Horton, JL, Lai, L, Vega, RB, Leone, TC, Koves, T, Gardell, SJ, Krüger, M, Hoppel, CL, Lewandowski, ED, Crawford, PA, Muoio, DM, and Kelly, DP. "The Failing Heart Relies on Ketone Bodies as a Fuel." Circulation 133, no. 8 (February 2016): 698-705.

PMID
26819376
Full Text

Barrientos, T, Laothamatas, I, Koves, TR, Soderblom, EJ, Bryan, M, Moseley, MA, Muoio, DM, and Andrews, NC. "Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle." Ebiomedicine 2, no. 11 (November 2015): 1705-1717.

PMID
26870796
Full Text

Kien, CL, Matthews, DE, Poynter, ME, Bunn, JY, Fukagawa, NK, Crain, KI, Ebenstein, DB, Tarleton, EK, Stevens, RD, Koves, TR, and Muoio, DM. "Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation." Journal of Lipid Research 56, no. 9 (September 2015): 1795-1807.

PMID
26156077
Full Text

Seiler, SE, Koves, TR, Gooding, JR, Wong, KE, Stevens, RD, Ilkayeva, OR, Wittmann, AH, DeBalsi, KL, Davies, MN, Lindeboom, L, Schrauwen, P, Schrauwen-Hinderling, VB, and Muoio, DM. "Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise." Cell Metabolism 22, no. 1 (July 2015): 65-76.

PMID
26154055
Full Text

Baker, PR, Boyle, KE, Koves, TR, Ilkayeva, OR, Muoio, DM, Houmard, JA, and Friedman, JE. "Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans." Obesity (Silver Spring, Md.) 23, no. 5 (May 2015): 981-988.

PMID
25864501
Full Text

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