Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

King, John D., Grant Rowland, Alejandro G. Villasante Tezanos, James Warwick, Virginia B. Kraus, Christian Lattermann, and Cale A. Jacobs. “Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State.” Cartilage 11, no. 3 (July 2020): 329–37. https://doi.org/10.1177/1947603518790009.

PMID
30033738
Full Text

Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Virginia B. Kraus, Todd A. Schwartz, Richard H. Gracely, Joanne M. Jordan, and Yvonne M. Golightly. “Different Phenotypes of Osteoarthritis in the Lumbar Spine Reflected by Demographic and Clinical Characteristics: The Johnston County Osteoarthritis Project.” In Arthritis Care Res (Hoboken), 72:974–81, 2020. https://doi.org/10.1002/acr.23918.

PMID
31058435
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Li, Zhi-Hao, Xiang Gao, Vincent Ch Chung, Wen-Fang Zhong, Qi Fu, Yue-Bin Lv, Zheng-He Wang, et al. “Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.” Ann Rheum Dis 79, no. 6 (June 2020): 829–36. https://doi.org/10.1136/annrheumdis-2020-217176.

PMID
32253185
Full Text

Zhang, Yi, Tiantian Li, Runmei Ma, Zhaoxue Yin, Jiaonan Wang, Mike Z. He, Dandan Xu, et al. “Long-term exposure to ambient fine particulate matter and fasting blood glucose level in a Chinese elderly cohort.” Sci Total Environ 717 (May 15, 2020): 137191. https://doi.org/10.1016/j.scitotenv.2020.137191.

PMID
32062280
Full Text

Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.” J Gerontol a Biol Sci Med Sci, May 9, 2020. https://doi.org/10.1093/gerona/glaa119.

PMID
32386291
Full Text

Goode, Adam P., Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Steven Z. George, Rebecca J. Cleveland, Richard Gracely, et al. “Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.” J Orthop Res 38, no. 5 (May 2020): 1027–37. https://doi.org/10.1002/jor.24534.

PMID
31750565
Full Text

Hsueh, M. -. F., M. P. Bolognesi, S. S. Wellman, and V. B. Kraus. “Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.” Osteoarthritis Cartilage 28, no. 5 (May 2020): 639–45. https://doi.org/10.1016/j.joca.2020.01.013.

PMID
32028022
Full Text

Huang, ZeYu, Jing Chen, BoLei Li, Benhua Zeng, Ching-Heng Chou, Xin Zheng, JingWei Xie, et al. “Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.” Ann Rheum Dis 79, no. 5 (May 2020): 646–56. https://doi.org/10.1136/annrheumdis-2019-216471.

PMID
32205337
Full Text

Han, Ashley J., Louie C. Alexander, Janet L. Huebner, Alexander B. Reed, and Virginia B. Kraus. “Increase in Free and Total Plasma TGF-β1 Following Physical Activity.” Cartilage, April 27, 2020, 1947603520916523. https://doi.org/10.1177/1947603520916523.

PMID
32340467
Full Text

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