Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Grants

Publications

Hsueh, Ming-Feng, Patrik Önnerfjord, Michael P. Bolognesi, Mark E. Easley, and Virginia B. Kraus. “Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs.” Science Advances 5, no. 10 (October 2019): eaax3203–eaax3203. https://doi.org/10.1126/sciadv.aax3203.

Full Text

Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing..” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.

PMID
31534056
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Heilmeier, U., K. Mamoto, K. Amano, B. Eck, M. Tanaka, J. A. Bullen, B. J. Schwaiger, et al. “Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile in young adults following ACL tear..” Osteoarthritis Cartilage, September 14, 2019. https://doi.org/10.1016/j.joca.2019.09.001.

PMID
31526878
Full Text

Jacobs, Cale A., Emily R. Hunt, Caitlin E-W Conley, Darren L. Johnson, Austin V. Stone, Janet L. Huebner, Virginia B. Kraus, and Christian Lattermann. “Dysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury..” Med Sci Sports Exerc, September 12, 2019. https://doi.org/10.1249/MSS.0000000000002161.

PMID
31524832
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Li, Zhi-Hao, Yue-Bin Lv, Wen-Fang Zhong, Xiang Gao, Virginia Byers Kraus, Meng-Chen Zou, Xi-Ru Zhang, et al. “High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly..” J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3370–78. https://doi.org/10.1210/jc.2018-02511.

PMID
30869791
Full Text

Li, Fu-Rong, Xi-Ru Zhang, Wen-Fang Zhong, Zhi-Hao Li, Xiang Gao, Virginia Byers Kraus, Yue-Bin Lv, et al. “Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes..” J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3345–54. https://doi.org/10.1210/jc.2018-02536.

PMID
30896760
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Huang, ZeYu, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen, and Virginia Byers Kraus. “Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials..” Arthritis Res Ther 21, no. 1 (July 15, 2019). https://doi.org/10.1186/s13075-019-1951-6.

PMID
31307506
Full Text

Bannuru, R. R., M. C. Osani, E. E. Vaysbrot, N. K. Arden, K. Bennell, S. M. A. Bierma-Zeinstra, V. B. Kraus, et al. “OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis..” Osteoarthritis Cartilage, July 3, 2019. https://doi.org/10.1016/j.joca.2019.06.011.

PMID
31278997
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Emery, Carolyn A., Jackie L. Whittaker, Armaghan Mahmoudian, L Stefan Lohmander, Ewa M. Roos, Kim L. Bennell, Clodagh M. Toomey, et al. “Establishing outcome measures in early knee osteoarthritis..” Nat Rev Rheumatol 15, no. 7 (July 2019): 438–48. https://doi.org/10.1038/s41584-019-0237-3.

PMID
31201386
Full Text

Haraden, Collin A., Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li, and Virginia Byers Kraus. “Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation..” Arthritis Res Ther 21, no. 1 (June 13, 2019). https://doi.org/10.1186/s13075-019-1923-x.

PMID
31196179
Full Text

Pages