Virginia Byers Kraus, MD, PhD

Professor of Medicine
Mary Bernheim Distinguished Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Zhang, Xi-Ru, Pei-Dong Zhang, Zhi-Hao Li, Pei Yang, Xiao-Meng Wang, Hua-Min Liu, Fen Liang, et al. “Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: A large prospective cohort study.” The British Journal of Nutrition, September 16, 2021, 1–35. https://doi.org/10.1017/s000711452100372x.

PMID
34526168
Full Text

Reed, A., Y. -. J. Li, E. Soderblom, A. Moseley, S. Sun, K. Zhou, N. Arden, A. Nelson, and V. B. Kraus. “SERUM PROTEOMIC BIOMARKERS DIAGNOSTIC OF KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S5–6, 2021.

Scholars@Duke

Sun, S., Y. -. J. Li, E. J. Soderblom, M. A. Moseley, K. Zhou, A. Reed, N. Arden, and V. B. Kraus. “SERUM PROGNOSTIC BIOMARKERS FOR INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S8–9, 2021.

Scholars@Duke

Zhou, K., Y. -. J. Li, E. Soderblom, A. Reed, S. Sun, M. A. Moseley, and V. B. Kraus. “QUALIFICTION OF PROTEOMIC BIOMARKERS FOR KNEE OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S7–8, 2021.

Scholars@Duke

Alexander, Louie C., Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal, and Virginia B. Kraus. “A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.” Arthritis Research & Therapy 23, no. 1 (August 31, 2021): 226. https://doi.org/10.1186/s13075-021-02610-y.

PMID
34465395
Full Text

Zhang, Xin, Janet L. Huebner, and Virginia Byers Kraus. “Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.” Int J Mol Sci 22, no. 15 (August 3, 2021). https://doi.org/10.3390/ijms22158351.

PMID
34361116
Full Text

Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res 39, no. 8 (August 2021): 1710–21. https://doi.org/10.1002/jor.24899.

PMID
33104263
Full Text

Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc, July 29, 2021. https://doi.org/10.1111/jgs.17384.

PMID
34325481
Full Text

Pages