Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Golightly, YM, Hannan, MT, Nelson, AE, Hillstrom, HJ, Cleveland, RJ, Kraus, VB, Schwartz, TA, Goode, AP, Flowers, P, Renner, JB, and Jordan, JM. "Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort." Arthritis Care & Research 71, no. 4 (April 2019): 538-544.

PMID
29953742
Full Text

Kraus, VB, Simon, LS, Katz, JN, Neogi, T, Hunter, D, Guermazi, A, and Karsdal, MA. "Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs." Osteoarthritis and Cartilage 27, no. 4 (April 2019): 571-579. (Review)

PMID
30465809
Full Text

Li, F-R, Zhang, X-R, Zhong, W-F, Li, Z-H, Gao, X, Kraus, VB, Lv, Y-B, Zou, M-C, Chen, G-C, Chen, P-L, Zhang, M-Y, Kur, AKA, Shi, X-M, Wu, X-B, and Mao, C. "Glycated Hemoglobin and All-cause and Cause-specific Mortality Among Adults With and Without Diabetes." The Journal of Clinical Endocrinology and Metabolism (March 21, 2019).

PMID
30896760
Full Text

Yin, Z, Brasher, MS, Kraus, VB, Lv, Y, Shi, X, and Zeng, Y. "Dietary Diversity Was Positively Associated with Psychological Resilience among Elders: A Population-Based Study." Nutrients 11, no. 3 (March 18, 2019).

PMID
30889808
Full Text

Li, Z-H, Lv, Y-B, Zhong, W-F, Gao, X, Kraus, VB, Zou, M-C, Zhang, X-R, Li, F-R, Yuan, J-Q, Shi, X-M, Wu, X-B, and Mao, C. "High-density Lipoprotein Cholesterol and All-cause and Cause-specific Mortality Among the Elderly." The Journal of Clinical Endocrinology and Metabolism (March 14, 2019).

PMID
30869791
Full Text

Spitzer, AI, Richmond, JC, Kraus, VB, Gomoll, A, Jones, DG, Huffman, KM, Peterfy, C, Cinar, A, Lufkin, J, and Kelley, SD. "Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study." Rheumatology and Therapy 6, no. 1 (March 2019): 109-124.

PMID
30741382
Full Text

Parker, D, Sloane, R, Pieper, CF, Hall, KS, Kraus, VB, Kraus, WE, Huebner, JL, Ilkayeva, OR, Bain, JR, Newby, LK, Cohen, HJ, and Morey, MC. "Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood." February 2019.

PMID
29985987
Full Text

Yuan, J-Q, Lv, Y-B, Chen, H-S, Gao, X, Yin, Z-X, Wang, W-T, Kraus, VB, Luo, J-S, Wang, J-N, Zeng, Y, Mao, C, and Shi, X-M. "Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association 20, no. 2 (February 2019): 177-182.e2.

PMID
30017702
Full Text

Lv, Y-B, Mao, C, Gao, X, Yin, Z-X, Kraus, VB, Yuan, J-Q, Zhang, J, Luo, J-S, Zeng, Y, and Shi, X-M. "Triglycerides Paradox Among the Oldest Old: "The Lower the Better?"." Journal of the American Geriatrics Society (January 10, 2019).

PMID
30628728
Full Text

Watt, FE, Corp, N, Kingsbury, SR, Frobell, R, Englund, M, Felson, DT, Levesque, M, Majumdar, S, Wilson, C, Beard, DJ, Lohmander, LS, Kraus, VB, Roemer, F, Conaghan, PG, Mason, DJ, and Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group, . "Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury." Osteoarthritis and Cartilage 27, no. 1 (January 2019): 23-33.

PMID
30125638
Full Text

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