Virginia Byers Kraus, MD, PhD

Professor of Medicine
Mary Bernheim Distinguished Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Bay-Jensen, Anne C., Ali Mobasheri, Christian S. Thudium, Virginia B. Kraus, and Morten A. Karsdal. “Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers.” Curr Opin Rheumatol 34, no. 1 (January 1, 2022): 54–60. https://doi.org/10.1097/BOR.0000000000000845.

PMID
34652292
Full Text

Huffman, Kim M., Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, et al. “Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.” Eclinicalmedicine 43 (January 2022): 101261. https://doi.org/10.1016/j.eclinm.2021.101261.

PMID
35028547
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Huang, Z. Y., Z. Y. Luo, Y. R. Cai, C. -. H. Chou, M. L. Yao, F. X. Pei, V. B. Kraus, and Z. K. Zhou. “Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing.” Osteoarthritis Cartilage, December 29, 2021. https://doi.org/10.1016/j.joca.2021.12.007.

PMID
34971754
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Han, Ashley J., Louie C. Alexander, Janet L. Huebner, Alexander B. Reed, and Virginia B. Kraus. “Increase in Free and Total Plasma TGF-β1 Following Physical Activity.” Cartilage 13, no. 1_suppl (December 2021): 1741S-1748S. https://doi.org/10.1177/1947603520916523.

PMID
32340467
Full Text

Zhou, Jinhui, Yuebin Lv, Feng Zhao, Yuan Wei, Xiang Gao, Chen Chen, Feng Lu, et al. “Albumin-corrected fructosamine predicts all-cause and non-CVD mortality among the very elderly aged ≥ 80 years without diabetes.” J Gerontol a Biol Sci Med Sci, November 10, 2021. https://doi.org/10.1093/gerona/glab339.

PMID
34758092
Full Text

Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc 69, no. 11 (November 2021): 3232–41. https://doi.org/10.1111/jgs.17384.

PMID
34325481
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Li, Zhi-Hao, Pei-Dong Zhang, Qing Chen, Xiang Gao, Vincent C. H. Chung, Dong Shen, Xi-Ru Zhang, et al. “Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.” European Journal of Endocrinology 185, no. 5 (October 19, 2021): 765–74. https://doi.org/10.1530/eje-21-0314.

PMID
34524977
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Allen, Nicholas B., Bijan Abar, Richard M. Danilkowicz, Virginia B. Kraus, Steven A. Olson, and Samuel B. Adams. “Intra-Articular Synovial Fluid With Hematoma After Ankle Fracture Promotes Cartilage Damage In Vitro Partially Attenuated by Anti-Inflammatory Agents.” Foot Ankle Int, October 7, 2021, 10711007211046952. https://doi.org/10.1177/10711007211046952.

PMID
34617803
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Zhang, Xi-Ru, Pei-Dong Zhang, Zhi-Hao Li, Pei Yang, Xiao-Meng Wang, Hua-Min Liu, Fen Liang, et al. “Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study.” Br J Nutr, September 16, 2021, 1–12. https://doi.org/10.1017/S000711452100372X.

PMID
34526168
Full Text

Pages