My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.
The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.
Education and Training
- Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
- Medical Resident, Medicine, Duke University, 1983 - 1986
- Ph.D., Duke University, 1993
- M.D., Duke University, 1982
- Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers
- Mechanical Biomarkers of Chronic Low Back Pain
- Weight loss, in vivo cartilage mechanics, and joint health
- Epigenetic Mechanisms Promoting Longevity
- University Training Program in Biomolecular and Tissue Engineering
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative)
- Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk)
- Qualification of Prognostic and Diagnostic Biomarkers of Knee Osteoarthritis
- Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience