Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Gullo, Terese R., Yvonne M. Golightly, Rebecca J. Cleveland, Jordan B. Renner, Leigh F. Callahan, Joanne M. Jordan, Virginia B. Kraus, and Amanda E. Nelson. “Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort..” Semin Arthritis Rheum 48, no. 6 (June 2019): 950–57. https://doi.org/10.1016/j.semarthrit.2018.10.001.

PMID
30390991
Full Text

Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Virginia B. Kraus, Todd A. Schwartz, Richard H. Gracely, Joanne M. Jordan, and Yvonne M. Golightly. “Demographic and clinical characteristics reflect different phenotypes of osteoarthritis in the lumbar spine: the Johnston County Osteoarthritis Project..” In Arthritis Care Res (Hoboken), 2019. https://doi.org/10.1002/acr.23918.

PMID
31058435
Full Text

Mao, Chen, Jin-Qiu Yuan, Yue-Bin Lv, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jie-Si Luo, et al. “Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study..” Bmc Geriatr 19, no. 1 (April 15, 2019). https://doi.org/10.1186/s12877-019-1109-z.

PMID
30987591
Full Text

Gullo, Terese R., Yvonne M. Golightly, Portia Flowers, Joanne M. Jordan, Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Marian T. Hannan, Rebecca J. Cleveland, and Amanda E. Nelson. “Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional study of older adults..” Bmc Musculoskelet Disord 20, no. 1 (April 11, 2019). https://doi.org/10.1186/s12891-019-2550-z.

PMID
30975124
Full Text

Goode, Adam P., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis..” Bmc Musculoskelet Disord 20, no. 1 (April 9, 2019). https://doi.org/10.1186/s12891-019-2523-2.

PMID
30967130
Full Text

Golightly, Yvonne M., Marian T. Hannan, Amanda E. Nelson, Howard J. Hillstrom, Rebecca J. Cleveland, Virginia B. Kraus, Todd A. Schwartz, et al. “Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort..” Arthritis Care Res (Hoboken) 71, no. 4 (April 2019): 538–44. https://doi.org/10.1002/acr.23686.

PMID
29953742
Full Text

Kraus, V. B., L. S. Simon, J. N. Katz, T. Neogi, D. Hunter, A. Guermazi, and M. A. Karsdal. “Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs..” Osteoarthritis Cartilage 27, no. 4 (April 2019): 571–79. https://doi.org/10.1016/j.joca.2018.11.002.

PMID
30465809
Full Text

Lv, Yue-Bin, Chen Mao, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jin-Qiu Yuan, Juan Zhang, Jie-Si Luo, Yi Zeng, and Xiao-Ming Shi. “Triglycerides Paradox Among the Oldest Old: "The Lower the Better?".” J Am Geriatr Soc 67, no. 4 (April 2019): 741–48. https://doi.org/10.1111/jgs.15733.

PMID
30628728
Full Text

Li, Fu-Rong, Xi-Ru Zhang, Wen-Fang Zhong, Zhi-Hao Li, Xiang Gao, Virginia Byers Kraus, Yue-Bin Lv, et al. “Glycated Hemoglobin and All-cause and Cause-specific Mortality Among Adults With and Without Diabetes..” J Clin Endocrinol Metab, March 21, 2019. https://doi.org/10.1210/jc.2018-02536.

PMID
30896760
Full Text

Yin, Zhaoxue, Melanie Sereny Brasher, Virginia B. Kraus, Yuebin Lv, Xiaoming Shi, and Yi Zeng. “Dietary Diversity Was Positively Associated with Psychological Resilience among Elders: A Population-Based Study..” Nutrients 11, no. 3 (March 18, 2019). https://doi.org/10.3390/nu11030650.

PMID
30889808
Full Text

Pages