Virginia Byers Kraus, MD, PhD

Professor of Medicine
Mary Bernheim Distinguished Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Goode, Adam P., David Hu, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Rebecca J. Cleveland, Kenneth A. Taylor, Joanne M. Jordan, and Yvonne M. Golightly. “Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project.” Osteoarthritis and Cartilage Open, May 2022, 100270–100270. https://doi.org/10.1016/j.ocarto.2022.100270.

Full Text

Cen, Han, Qingran Yan, Weiyu Han, Tao Meng, Zhongshan Chen, Guangfeng Ruan, Tian Wang, et al. “Longitudinal Association of Infrapatellar Fat Pad Signal Intensity Alteration with Biochemical Biomarkers in Knee Osteoarthritis.” Rheumatology (Oxford), April 6, 2022. https://doi.org/10.1093/rheumatology/keac214.

PMID
35385111
Full Text

Zhang, X., S. Ma, A. Reed, T. Ho, G. Waitt, E. J. Soderblom, C. Aliferis, and V. B. Kraus. “PROTEOMIC SIGNATURES OF EXTRACELLULAR VESICLES DERIVED FROM SYNOVIAL FLUID AND PLASMA OF PARTICIPANTS WITH KNEE OSTEOARTHRITIS.” Osteoarthritis and Cartilage 30 (April 2022): S121–S121. https://doi.org/10.1016/j.joca.2022.02.154.

Full Text

Reed, A., M. -. F. Hsueh, J. L. Huebner, Y. -. J. Li, B. Ma, A. Krych, S. Rodeo, S. Majumdar, and V. B. Kraus. “SURGERY INDUCES SECOND CYTOKINE STORM IN INDIVIDUALS WHO EXPERIENCE AN ANTERIOR CRUCIATE LIGAMENT TEAR.” In Osteoarthritis and Cartilage, 30:S100–101, 2022.

Scholars@Duke

Hsueh, M. -. F., A. Reed, M. Orenduff, M. P. Bolognesi, M. E. Easley, P. Onnerfjord, and V. B. Kraus. “CARTILAGE ANABOLISM IS HIGHLY REGULATED BY MIRNAS IN RESPONSE TO OA STRESS.” In Osteoarthritis and Cartilage, 30:S356–57, 2022.

Scholars@Duke

Allen, Nicholas B., Bijan Abar, Richard M. Danilkowicz, Virginia B. Kraus, Steven A. Olson, and Samuel B. Adams. “Intra-Articular Synovial Fluid With Hematoma After Ankle Fracture Promotes Cartilage Damage In Vitro Partially Attenuated by Anti-Inflammatory Agents.” Foot Ankle Int 43, no. 3 (March 2022): 426–38. https://doi.org/10.1177/10711007211046952.

PMID
34617803
Full Text

Huang, Z. Y., Z. Y. Luo, Y. R. Cai, C. -. H. Chou, M. L. Yao, F. X. Pei, V. B. Kraus, and Z. K. Zhou. “Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing.” Osteoarthritis Cartilage 30, no. 3 (March 2022): 475–80. https://doi.org/10.1016/j.joca.2021.12.007.

PMID
34971754
Full Text

Jacobs, Cale A., Caitlin E. W. Conley, Virginia Byers Kraus, Drew A. Lansdown, Brian C. Lau, Xiaojuan Li, Sharmila Majumdar, Kurt P. Spindler, Nicole G. Lemaster, and Austin V. Stone. “MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.” Trials 23, no. 1 (January 31, 2022): 98. https://doi.org/10.1186/s13063-021-05982-3.

PMID
35101085
Full Text

Bay-Jensen, Anne C., Ali Mobasheri, Christian S. Thudium, Virginia B. Kraus, and Morten A. Karsdal. “Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers.” Curr Opin Rheumatol 34, no. 1 (January 1, 2022): 54–60. https://doi.org/10.1097/BOR.0000000000000845.

PMID
34652292
Full Text

Huffman, Kim M., Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, et al. “Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.” Eclinicalmedicine 43 (January 2022): 101261. https://doi.org/10.1016/j.eclinm.2021.101261.

PMID
35028547
Full Text

Pages