Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Xie, J. W., Y. Wang, K. Xiao, H. Xu, Z. Y. Luo, L. Li, F. X. Pei, V. B. Kraus, and Z. Y. Huang. “Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.” In Osteoarthritis Cartilage, 29:1048–59, 2021. https://doi.org/10.1016/j.joca.2021.04.006.

PMID
33892137
Full Text

Furman, B. D., J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, and S. A. Olson. “Immune cell profiling in the joint following human and murine articular fracture.” Osteoarthritis Cartilage 29, no. 6 (June 2021): 915–23. https://doi.org/10.1016/j.joca.2021.02.565.

PMID
33640582
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Luo, Yunyun, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, and Anne C. Bay-Jensen. “A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.” J Orthop Traumatol 22, no. 1 (March 9, 2021): 10. https://doi.org/10.1186/s10195-021-00572-0.

PMID
33687578
Full Text

Hunter, David J., Leticia A. Deveza, Jamie E. Collins, Elena Losina, Michael C. Nevitt, Frank W. Roemer, Ali Guermazi, et al. “Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium.” Arthritis Care Res (Hoboken), January 9, 2021. https://doi.org/10.1002/acr.24557.

PMID
33421361
Full Text

Hsueh, Ming-Feng, Xin Zhang, Samuel S. Wellman, Michael P. Bolognesi, and Virginia B. Kraus. “Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.” Arthritis Rheumatol 73, no. 1 (January 2021): 89–99. https://doi.org/10.1002/art.41486.

PMID
32783329
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Ross, Leanna M., Cris A. Slentz, Alyssa M. Zidek, Kim M. Huffman, Irina Shalaurova, James D. Otvos, Margery A. Connelly, et al. “Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.” Front Physiol 12 (2021): 626142. https://doi.org/10.3389/fphys.2021.626142.

PMID
33613319
Full Text

Ramalingam, Sendhilnathan, Sharareh Siamakpour-Reihani, Lauren Bohannan, Yi Ren, Alexander Sibley, Jeff Sheng, Li Ma, et al. “A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.” Plos One 16, no. 6 (2021): e0252995. https://doi.org/10.1371/journal.pone.0252995.

PMID
34170918
Full Text

Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res, October 26, 2020. https://doi.org/10.1002/jor.24899.

PMID
33104263
Full Text

Li, Zhi-Hao, Yue-Bin Lv, Virginia Byers Kraus, Zhao-Xue Yin, Si-Min Liu, Xiao-Chang Zhang, Xiang Gao, et al. “Trends in the Incidence of Activities of Daily Living Disability Among Chinese Older Adults From 2002 to 2014.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 11 (October 2020): 2113–18. https://doi.org/10.1093/gerona/glz221.

PMID
31603986
Full Text

Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.” J Gerontol a Biol Sci Med Sci 75, no. 10 (September 25, 2020): e166–72. https://doi.org/10.1093/gerona/glaa119.

PMID
32386291
Full Text

Pages