Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Yuan, J-Q, Lv, Y-B, Chen, H-S, Gao, X, Yin, Z-X, Wang, W-T, Kraus, VB, Luo, J-S, Wang, J-N, Zeng, Y, Mao, C, and Shi, X-M. "Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association 20, no. 2 (February 2019): 177-182.e2.

PMID
30017702
Full Text

Lv, Y-B, Mao, C, Gao, X, Yin, Z-X, Kraus, VB, Yuan, J-Q, Zhang, J, Luo, J-S, Zeng, Y, and Shi, X-M. "Triglycerides Paradox Among the Oldest Old: "The Lower the Better?"." Journal of the American Geriatrics Society (January 10, 2019).

PMID
30628728
Full Text

Watt, FE, Corp, N, Kingsbury, SR, Frobell, R, Englund, M, Felson, DT, Levesque, M, Majumdar, S, Wilson, C, Beard, DJ, Lohmander, LS, Kraus, VB, Roemer, F, Conaghan, PG, Mason, DJ, and Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group, . "Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury." Osteoarthritis and Cartilage 27, no. 1 (January 2019): 23-33.

PMID
30125638
Full Text

Andonian, BJ, Bartlett, DB, Huebner, JL, Willis, L, Hoselton, A, Kraus, VB, Kraus, WE, and Huffman, KM. "Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes." Arthritis Research & Therapy 20, no. 1 (December 27, 2018): 283-null.

PMID
30587230
Full Text

Huang, ZY, Perry, E, Huebner, JL, Katz, B, Li, Y-J, and Kraus, VB. "Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial." Osteoarthritis and Cartilage 26, no. 12 (December 2018): 1658-1665.

PMID
30144513
Full Text

Kraus, VB, Simon, LS, Katz, JN, Neogi, T, Hunter, D, Guermazi, A, and Karsdal, MA. "Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs." Osteoarthritis and Cartilage (November 19, 2018). (Review)

PMID
30465809
Full Text

Gullo, TR, Golightly, YM, Cleveland, RJ, Renner, JB, Callahan, LF, Jordan, JM, Kraus, VB, and Nelson, AE. "Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort." Seminars in Arthritis and Rheumatism (October 9, 2018).

PMID
30390991
Full Text

Lv, Y-B, Yuan, J-Q, Mao, C, Gao, X, Yin, Z-X, Kraus, VB, Luo, J-S, Chen, H-S, Zeng, Y, Wang, W-T, Wang, J-N, and Shi, X-M. "Association of Body Mass Index With Disability in Activities of Daily Living Among Chinese Adults 80 Years of Age or Older." Jama Network Open 1, no. 5 (September 7, 2018): e181915-null.

PMID
30646143
Full Text

Goode, AP, Cleveland, B, Schwartz, T, George, SZ, Kraus, VB, Gracely, R, Chen, J, Jordan, JM, and Golightly, YM. "Demographic and Clinical Characteristics Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: The Johnston County Osteoarthritis Project.": WILEY, September 1, 2018.

Scholars@Duke

Andonian, BJ, Chou, C-H, Kraus, VB, Kraus, WE, and Huffman, KM. "Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis.": WILEY, September 1, 2018.

Scholars@Duke

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