Virginia Byers Kraus, MD, PhD

Professor of Medicine
Mary Bernheim Distinguished Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Zhang, Xi-Ru, Pei-Dong Zhang, Zhi-Hao Li, Pei Yang, Xiao-Meng Wang, Hua-Min Liu, Fen Liang, et al. “Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: A large prospective cohort study.” The British Journal of Nutrition, September 16, 2021, 1–35.

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Reed, A., Y. -. J. Li, E. Soderblom, A. Moseley, S. Sun, K. Zhou, N. Arden, A. Nelson, and V. B. Kraus. “SERUM PROTEOMIC BIOMARKERS DIAGNOSTIC OF KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S5–6, 2021.


Sun, S., Y. -. J. Li, E. J. Soderblom, M. A. Moseley, K. Zhou, A. Reed, N. Arden, and V. B. Kraus. “SERUM PROGNOSTIC BIOMARKERS FOR INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S8–9, 2021.


Zhou, K., Y. -. J. Li, E. Soderblom, A. Reed, S. Sun, M. A. Moseley, and V. B. Kraus. “QUALIFICTION OF PROTEOMIC BIOMARKERS FOR KNEE OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S7–8, 2021.


Alexander, Louie C., Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal, and Virginia B. Kraus. “A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.” Arthritis Research & Therapy 23, no. 1 (August 31, 2021): 226.

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Zhang, Xin, Janet L. Huebner, and Virginia Byers Kraus. “Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.” Int J Mol Sci 22, no. 15 (August 3, 2021).

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Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res 39, no. 8 (August 2021): 1710–21.

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Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc, July 29, 2021.

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