Virginia Byers Kraus, MD, PhD

Professor of Medicine
Mary Bernheim Distinguished Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Duke Regeneration Center
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Alexander, Louie C., Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal, and Virginia B. Kraus. “A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.” Arthritis Research & Therapy 23, no. 1 (August 31, 2021): 226. https://doi.org/10.1186/s13075-021-02610-y.

PMID
34465395
Full Text

Zhang, Xin, Janet L. Huebner, and Virginia Byers Kraus. “Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.” Int J Mol Sci 22, no. 15 (August 3, 2021). https://doi.org/10.3390/ijms22158351.

PMID
34361116
Full Text

Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res 39, no. 8 (August 2021): 1710–21. https://doi.org/10.1002/jor.24899.

PMID
33104263
Full Text

Xie, J. W., Y. Wang, K. Xiao, H. Xu, Z. Y. Luo, L. Li, F. X. Pei, V. B. Kraus, and Z. Y. Huang. “Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.” In Osteoarthritis Cartilage, 29:1048–59, 2021. https://doi.org/10.1016/j.joca.2021.04.006.

PMID
33892137
Full Text

Furman, B. D., J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, and S. A. Olson. “Immune cell profiling in the joint following human and murine articular fracture.” Osteoarthritis Cartilage 29, no. 6 (June 2021): 915–23. https://doi.org/10.1016/j.joca.2021.02.565.

PMID
33640582
Full Text

Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Jordan B. Renner, Richard H. Gracely, et al. “Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.” Arthritis Care Res (Hoboken), May 10, 2021. https://doi.org/10.1002/acr.24643.

PMID
33973412
Full Text

Hsueh, M. -. F., J. L. Huebner, C. A. Jacobs, C. Lattermann, K. P. Spindler, and V. B. Kraus. “ASSOCIATION OF MATRIX METALLOPEPTIDASE 9 WITH NEUTROPHIL ELASTASE IN JOINT INJURY AND OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S65–66, 2021.

Scholars@Duke

Luo, Yunyun, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, and Anne C. Bay-Jensen. “A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.” J Orthop Traumatol 22, no. 1 (March 9, 2021): 10. https://doi.org/10.1186/s10195-021-00572-0.

PMID
33687578
Full Text

Hunter, David J., Leticia A. Deveza, Jamie E. Collins, Elena Losina, Michael C. Nevitt, Frank W. Roemer, Ali Guermazi, et al. “Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium.” Arthritis Care Res (Hoboken), January 9, 2021. https://doi.org/10.1002/acr.24557.

PMID
33421361
Full Text

Hsueh, Ming-Feng, Xin Zhang, Samuel S. Wellman, Michael P. Bolognesi, and Virginia B. Kraus. “Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.” Arthritis Rheumatol 73, no. 1 (January 2021): 89–99. https://doi.org/10.1002/art.41486.

PMID
32783329
Full Text

Pages