Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Longobardi, L, Jordan, JM, Shi, XA, Renner, JB, Schwartz, TA, Nelson, AE, Barrow, DA, Kraus, VB, and Spagnoli, A. "Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project." Osteoarthritis and Cartilage (May 2018).

PMID
29723633
Full Text

Flowers, PPE, Cleveland, RJ, Schwartz, TA, Nelson, AE, Kraus, VB, Hillstrom, HJ, Goode, AP, Hannan, MT, Renner, JB, Jordan, JM, and Golightly, YM. "Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study." Arthritis Research & Therapy 20, no. 1 (April 18, 2018): 76-null.

PMID
29669593
Full Text

Yin, Z, Chen, J, Zhang, J, Ren, Z, Dong, K, Kraus, VB, Wang, Z, Zhang, M, Zhai, Y, Song, P, Zhao, Y, Pang, S, Mi, S, and Zhao, W. "Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study." Nutrients 10, no. 4 (April 9, 2018).

PMID
29642510
Full Text

Hsueh, M-F, Onnerfjord, P, Bolognesi, MP, Easley, ME, and Kraus, VB. "DIFFERENTIAL CARTILAGE TURNOVER ALONG THE HUMAN LOWER LIMB REVEALED BY PROTEIN DEAMIDATION." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Hsueh, M-F, Lu, Y, Wellman, SS, Bolognesi, MP, and Kraus, VB. "FUNCTIONAL FOLATE RECEPTOR CELL-ASSOCIATED INFLAMMATORY CYTOKINES PREDICT THE PROGRESSION OF KNEE OSTEOARTHRITIS." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Chen, Y-H, Chou, C-H, Khodabukus, A, Bursac, N, Truskey, G, Kraus, W, and Kraus, VB. "EFFECTS OF SIMULATED MUSCLE EXERCISE ON CHONDROCYTE GENE EXPRESSION IN A 3D-ALGINATE BEAD MODEL SYSTEM." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Katz, NP, Conaghan, PG, Kraus, VB, Lufkin, J, Johnson, JR, and Kelley, S. "TRIAMCINOLONE ACETONIDE EXTENDED-RELEASE INJECTABLE SUSPENSION (TA-ER) PROVIDES CLINICALLY RELEVANT IMPROVEMENTS IN PAIN AND FUNCTION OF KNEE OSTEOARTHRITIS: A POOLED ANALYSIS OF 3 RANDOMIZED CLINICAL TRIALS EMPLOYING COMPOSITE ASSESSMENTS." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Karsdal, MA, Bay-Jensen, A-C, Bihlet, AR, Kraus, VB, Byrjalsen, I, and Andersen, JR. "OSTEOARTHRITIS CLINICAL TRIAL DESIGN AND FOOD AND DRUG ADMINISTRATION ACCELERATED APPROVAL: LESSONS LEARNED FROM THE OSTEOPOROSIS AND LIVER FIBROSIS FIELDS." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Huebner, JL, Haraden, C, Li, Y-J, and Kraus, VB. "BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Peterson, RO, Hoy, SR, Vucetich, LM, Vucetich, JA, Kraus, VB, and Huebner, JL. "URINARY BIOMARKERS TO NON-INVASIVELY EVALUATE HEALTH IN WILD MOOSE (ALCES ALCES)." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

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