Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Mao, Chen, Fu-Rong Li, Zhao-Xue Yin, Yue-Bin Lv, Jie-Si Luo, Jin-Qiu Yuan, Florence Mhungu, et al. “Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.” J Nutr 149, no. 6 (June 1, 2019): 1056–64. https://doi.org/10.1093/jn/nxz041.

PMID
30949685
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Gullo, Terese R., Yvonne M. Golightly, Rebecca J. Cleveland, Jordan B. Renner, Leigh F. Callahan, Joanne M. Jordan, Virginia B. Kraus, and Amanda E. Nelson. “Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.” Semin Arthritis Rheum 48, no. 6 (June 2019): 950–57. https://doi.org/10.1016/j.semarthrit.2018.10.001.

PMID
30390991
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Kraus, Virginia B., Kyle Sprow, Kenneth E. Powell, David Buchner, Bonny Bloodgood, Katrina Piercy, Stephanie M. George, William E. Kraus, and William E. 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*. “Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.” Med Sci Sports Exerc 51, no. 6 (June 2019): 1324–39. https://doi.org/10.1249/MSS.0000000000001944.

PMID
31095089
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Huffman, Kim M., John Richmond, Andrew Spitzer, Andreas Gomoll, Deryk G. Jones, Virginia B. Kraus, Amy Cinar, Joelle Lufkin, and Scott Kelley. “Initial/Repeat Triamcinolone Acetonide Extended-Release (TA-ER) Reduces Osteoarthritis Knee Pain Regardless of Prior Intra-Articular Corticosteroids (IACS).” In Medicine & Science in Sports & Exercise, 51:876–876. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1249/01.mss.0000563118.31561.b3.

Full Text

Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Virginia B. Kraus, Todd A. Schwartz, Richard H. Gracely, Joanne M. Jordan, and Yvonne M. Golightly. “Demographic and clinical characteristics reflect different phenotypes of osteoarthritis in the lumbar spine: the Johnston County Osteoarthritis Project.” In Arthritis Care Res (Hoboken), 2019. https://doi.org/10.1002/acr.23918.

PMID
31058435
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Mao, Chen, Jin-Qiu Yuan, Yue-Bin Lv, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jie-Si Luo, et al. “Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.” Bmc Geriatr 19, no. 1 (April 15, 2019): 104. https://doi.org/10.1186/s12877-019-1109-z.

PMID
30987591
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Gullo, Terese R., Yvonne M. Golightly, Portia Flowers, Joanne M. Jordan, Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Marian T. Hannan, Rebecca J. Cleveland, and Amanda E. Nelson. “Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional study of older adults.” Bmc Musculoskelet Disord 20, no. 1 (April 11, 2019): 165. https://doi.org/10.1186/s12891-019-2550-z.

PMID
30975124
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Goode, Adam P., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.” Bmc Musculoskelet Disord 20, no. 1 (April 9, 2019): 158. https://doi.org/10.1186/s12891-019-2523-2.

PMID
30967130
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Golightly, Yvonne M., Marian T. Hannan, Amanda E. Nelson, Howard J. Hillstrom, Rebecca J. Cleveland, Virginia B. Kraus, Todd A. Schwartz, et al. “Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort.” Arthritis Care Res (Hoboken) 71, no. 4 (April 2019): 538–44. https://doi.org/10.1002/acr.23686.

PMID
29953742
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Kraus, V. B., L. S. Simon, J. N. Katz, T. Neogi, D. Hunter, A. Guermazi, and M. A. Karsdal. “Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs.” Osteoarthritis Cartilage 27, no. 4 (April 2019): 571–79. https://doi.org/10.1016/j.joca.2018.11.002.

PMID
30465809
Full Text

Pages