Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Chen, J. C., V. B. Kraus, L. F. Callahan, T. Stabler, J. B. Renner, and J. M. Jordan. “Higher educational level is associated with decreased serum cartilage oligomeric matrix protein (COMP).” In Arthritis and Rheumatism, 58:S492–S492. WILEY-LISS, 2008.

Scholars@Duke

Pells, Jennifer J., Rebecca A. Shelby, Francis J. Keefe, Kim E. Dixon, James A. Blumenthal, Lara Lacaille, Jessica M. Tucker, Daniel Schmitt, David S. Caldwell, and Virginia B. Kraus. “Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain..” Pain 136, no. 3 (June 2008): 340–47. https://doi.org/10.1016/j.pain.2007.07.012.

PMID
17764844
Full Text

Ward, Benjamin D., Bridgette D. Furman, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse..” Arthritis Rheum 58, no. 3 (March 2008): 744–53. https://doi.org/10.1002/art.23288.

PMID
18311808
Full Text

Elliott, A. L., V. B. Kraus, F. Fang, J. B. Renner, T. A. Schwartz, A. Salazar, T. Huguenin, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project..” Ann Rheum Dis 66, no. 12 (December 2007): 1622–26. https://doi.org/10.1136/ard.2006.057422.

PMID
17504840
Full Text

Shamji, Mohammed F., Helawe Betre, Virginia B. Kraus, Jun Chen, Ashutosh Chilkoti, Rajeswari Pichika, Koichi Masuda, and Lori A. Setton. “Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic..” Arthritis Rheum 56, no. 11 (November 2007): 3650–61. https://doi.org/10.1002/art.22952.

PMID
17968946
Full Text

Charles, H. C., V. B. Kraus, M. Ainslie, and M. -. P. Hellio Le Graverand-Gastineau. “Optimization of the fixed-flexion knee radiograph..” Osteoarthritis Cartilage 15, no. 11 (November 2007): 1221–24. https://doi.org/10.1016/j.joca.2007.05.012.

PMID
17977754
Full Text

Kraus, V. B., T. V. Stabler, S. Y. Kong, G. Varju, and G. McDaniel. “Measurement of synovial fluid volume using urea..” Osteoarthritis Cartilage 15, no. 10 (October 2007): 1217–20. https://doi.org/10.1016/j.joca.2007.03.017.

PMID
17507255
Full Text

Henrotin, Yves, Shelby Addison, Virginia Kraus, and Michelle Deberg. “Type II collagen markers in osteoarthritis: what do they indicate?.” Curr Opin Rheumatol 19, no. 5 (September 2007): 444–50. https://doi.org/10.1097/BOR.0b013e32829fb3b5.

PMID
17762609
Full Text

Kraus, V. B., T. V. Stabler, G. Luta, J. B. Renner, A. D. Dragomir, and J. M. Jordan. “Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis..” Osteoarthritis Cartilage 15, no. 8 (August 2007): 966–71. https://doi.org/10.1016/j.joca.2007.02.014.

PMID
17395501
Full Text

Pages