Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Chen, Hsiang-Cheng, Svati H. Shah, Yi-Ju Li, Thomas V. Stabler, Joanne M. Jordan, and Virginia Byers Kraus. “Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels..” Arthritis and Rheumatism 58, no. 12 (December 2008): 3854–64. https://doi.org/10.1002/art.24319.

PMID
19035482
Full Text

Mazzuca, S. A., M. -. P. Hellio Le Graverand, E. Vignon, D. J. Hunter, C. G. Jackson, V. B. Kraus, T. M. Link, T. J. Schnitzer, A. Vaz, and H. C. Charles. “Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees..” Osteoarthritis and Cartilage 16, no. 12 (December 2008): 1555–59. https://doi.org/10.1016/j.joca.2008.04.010.

PMID
18515156
Full Text

Seifer, D. R., B. D. Furman, F. Guilak, S. A. Olson, S Carroll Brooks, and V Byers Kraus. “Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice..” Osteoarthritis and Cartilage 16, no. 12 (December 2008): 1532–38. https://doi.org/10.1016/j.joca.2008.04.013.

PMID
18538588
Full Text

Le Graverand, M-P Hellio, E. P. Vignon, K. D. Brandt, S. A. Mazzuca, M. Piperno, R. Buck, H. C. Charles, et al. “Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees..” Annals of the Rheumatic Diseases 67, no. 11 (November 2008): 1562–66. https://doi.org/10.1136/ard.2007.077834.

PMID
18258709
Full Text

Atif, U., A. Philip, J. Aponte, E. M. Woldu, S. Brady, V. B. Kraus, J. M. Jordan, et al. “Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians..” Osteoarthritis Cartilage 16, no. 10 (October 2008): 1174–77. https://doi.org/10.1016/j.joca.2008.03.007.

PMID
18434216
Full Text

Quintana, D. J., P. Garnero, J. L. Huebner, N. Charni-Ben Tabassi, and V. B. Kraus. “PIIANP and HELIXII diurnal variation..” Osteoarthritis and Cartilage 16, no. 10 (October 2008): 1192–95. https://doi.org/10.1016/j.joca.2008.03.006.

PMID
18434215
Full Text

Chen, J. C., V. B. Kraus, L. F. Callahan, T. Stabler, J. B. Renner, and J. M. Jordan. “Higher educational level is associated with decreased serum cartilage oligomeric matrix protein (COMP).” In Arthritis and Rheumatism, 58:S492–S492. WILEY-LISS, 2008.

Scholars@Duke

Nelson, Amanda E., Fang Fang, Virginia B. Kraus, Thomas Stabler, Jordan B. Renner, Charles G. Helmick, and Joanne M. Jordan. “Is serum transforming growth factor-beta (TGF-beta) a biomarker of radiographic osteoarthritis (rOA) at the knee and hip?.” In Arthritis and Rheumatism, 58:S492–S492. WILEY-LISS, 2008.

Scholars@Duke

Chen, H. -. C., S. Shah, T. V. Stabler, Y. -. J. Li, and V. B. Kraus. “Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study..” Osteoarthritis and Cartilage 16, no. 9 (September 2008): 1054–59. https://doi.org/10.1016/j.joca.2007.12.010.

PMID
18291686
Full Text

Pells, Jennifer J., Rebecca A. Shelby, Francis J. Keefe, Kim E. Dixon, James A. Blumenthal, Lara Lacaille, Jessica M. Tucker, Daniel Schmitt, David S. Caldwell, and Virginia B. Kraus. “Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain..” Pain 136, no. 3 (June 2008): 340–47. https://doi.org/10.1016/j.pain.2007.07.012.

PMID
17764844
Full Text

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