Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huebner, JL, Haraden, C, Li, Y-J, and Kraus, VB. "BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE." OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. Liverpool, ENGLAND. April 26, 2018 - April 29, 2018.: ELSEVIER SCI LTD, April 1, 2018.

Scholars@Duke

Goode, A, Kraus, VB, Golightly, Y, Huebner, J, George, S, Martin, J, DeFrate, L, and Jordan, JM. "ASSOCIATION BETWEEN N-CADHERIN, KERATIN-19 AND LUMICAN WITH DISC SPACE NARROWING: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT." Osteoarthritis and Cartilage 26 (April 1, 2018): S421-S421.

Scholars@Duke

Mao, C, Yuan, J-Q, Lv, Y-B, Gao, X, Yin, Z-X, Kraus, VB, Luo, J-S, Chei, C-L, Matchar, DB, Zeng, Y, and Shi, X. "Associations between Superoxide Dismutase, Malondialdehyde and All-Cause Mortality in Older Adults: A Community-Based Cohort Study." (March 9, 2018).

Scholars@Duke

McIlwraith, CW, Kawcak, CE, Frisbie, DD, Little, CB, Clegg, PD, Peffers, MJ, Karsdal, MA, Ekman, S, Laverty, S, Slayden, RA, Sandell, LJ, Lohmander, LS, and Kraus, VB. "Biomarkers for equine joint injury and osteoarthritis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society 36, no. 3 (March 2018): 823-831. (Review)

PMID
28921609
Full Text

Amano, K, Huebner, JL, Stabler, TV, Tanaka, M, McCulloch, CE, Lobach, I, Lane, NE, Kraus, VB, Ma, CB, and Li, X. "Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery." The American Journal of Sports Medicine 46, no. 4 (March 2018): 890-899.

PMID
29364702
Full Text

ZeYu Huang, YN, Xu, B, Shen, B, Kraus, VB, and Pei, F. "Evidence and mechanism by which upper partial fibulectomy improves knee biomechanics and decreases knee pain of osteoarthritis." Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society (February 9, 2018).

PMID
29424452
Full Text

Chou, C-H, Attarian, DE, Wisniewski, H-G, Band, PA, and Kraus, VB. "TSG-6 - a double-edged sword for osteoarthritis (OA)." February 2018.

PMID
29129649
Full Text

Luyten, FP, Bierma-Zeinstra, S, Dell'Accio, F, Kraus, VB, Nakata, K, Sekiya, I, Arden, NK, and Lohmander, LS. "Toward classification criteria for early osteoarthritis of the knee." Seminars in Arthritis and Rheumatism 47, no. 4 (February 2018): 457-463.

PMID
28917712
Full Text

Kraus, VB, Conaghan, PG, Aazami, HA, Mehra, P, Kivitz, AJ, Lufkin, J, Hauben, J, Johnson, JR, and Bodick, N. "Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)." January 2018.

PMID
29024802
Full Text

Kraus, VB, Collins, JE, Charles, HC, Pieper, CF, Whitley, L, Losina, E, Nevitt, M, Hoffmann, S, Roemer, F, Guermazi, A, Hunter, DJ, and OA Biomarkers Consortium, . "Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium." Arthritis & Rheumatology (Hoboken, N.J.) 70, no. 1 (January 2018): 80-87.

PMID
29024470
Full Text

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