Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, VB, Conaghan, PG, Aazami, HA, Mehra, P, Kivitz, AJ, Lufkin, J, Hauben, J, Johnson, JR, and Bodick, N. "Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)." January 2018.

PMID
29024802
Full Text

Kraus, VB, Collins, JE, Charles, HC, Pieper, CF, Whitley, L, Losina, E, Nevitt, M, Hoffmann, S, Roemer, F, Guermazi, A, Hunter, DJ, and OA Biomarkers Consortium, . "Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium." Arthritis & Rheumatology (Hoboken, N.J.) 70, no. 1 (January 2018): 80-87.

PMID
29024470
Full Text

Huang, Z, Xie, X, Li, L, Huang, Q, Ma, J, Shen, B, Kraus, VB, and Pei, F. "Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial." The Journal of Bone and Joint Surgery. American Volume 99, no. 24 (December 2017): 2053-2061.

PMID
29257010
Full Text

Goode, AP, Nelson, AE, Kraus, VB, Renner, JB, and Jordan, JM. "Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project." October 2017.

PMID
28711584
Full Text

Adams, SB, Reilly, RM, Huebner, JL, Kraus, VB, and Nettles, DL. "Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture." Foot & Ankle International 38, no. 10 (October 2017): 1055-1063.

PMID
28891711
Full Text

Feng, S, Chen, S, Wang, L, Peterfy, C, Kraus, VB, Kamath, R, Zhang, L, Luo, Y, Cui, L, Medema, JK, and Levesque, MC. "Biomarkers Predictive of Pain Improvement in Knee Osteoarthritis Subjects Treated with the Anti-IL-1 alpha/beta Dual Variable Domain Immunoglobulin ABT-981." October 2017.

Scholars@Duke

Andonian, BJ, Bartlett, D, Kraus, VB, Huebner, J, Kraus, WE, and Huffman, KM. "Skeletal Muscle Cytokine and Myostatin Responses to High-Intensity Interval Training in Rheumatoid Arthritis Contrasted with Prediabetes Mellitus." October 2017.

Scholars@Duke

Andonian, BJ, Bartlett, D, Kraus, VB, Huebner, J, Kraus, WE, and Huffman, KM. "Serum Galectin-3 in Rheumatoid Arthritis Compared with Healthy Controls and Subjects with Prediabetes before and after High-Intensity Interval Training." October 2017.

Scholars@Duke

Conaghan, PG, Berenbaum, F, Kraus, VB, Johnson, J, and Kelley, S. "Updating the Knee Osteoarthritis Intra-Articular Corticosteroid Meta-Analysis with Two Large Trials of Extended-Release Triamcinolone Acetonide (FX006) Versus Placebo." October 2017.

Scholars@Duke

Furman, BD, Kent, CL, Huebner, JL, Kraus, VB, McNulty, AL, Guilak, F, and Olson, SA. "CXCL10 is upregulated in synovium and cartilage following articular fracture." Journal of orthopaedic research : official publication of the Orthopaedic Research Society (September 14, 2017).

PMID
28906016
Full Text

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