Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Hsueh, M. -. F., E. Montell, and V. B. Kraus. “AB0071 Effects of chondroitin sulphate and glucosamine on inflammatory cytokines in macrophages.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.2954.

Full Text

Hsueh, M. -. F., and V. B. Kraus. “AB0072 Evaluation of anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.3337.

Full Text

Deveza, L. A., V. B. Kraus, J. E. Collins, A. Guermazi, F. W. Roemer, M. C. Nevitt, and D. J. Hunter. “Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative..” Scand J Rheumatol 47, no. 3 (May 2018): 235–42. https://doi.org/10.1080/03009742.2017.1340511.

PMID
28929915
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Leung, Y. Y., B. Haaland, J. L. Huebner, S. B. S. Wong, M. Tjai, C. Wang, B. Chowbay, et al. “Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial..” Osteoarthritis Cartilage 26, no. 5 (May 2018): 631–40. https://doi.org/10.1016/j.joca.2018.01.026.

PMID
29426008
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Flowers, Portia P. E., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Adam P. Goode, et al. “Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study..” Arthritis Res Ther 20, no. 1 (April 18, 2018). https://doi.org/10.1186/s13075-018-1570-7.

PMID
29669593
Full Text

Conaghan, Philip G., David J. Hunter, Stanley B. Cohen, Virginia B. Kraus, Francis Berenbaum, Jay R. Lieberman, Deryk G. Jones, et al. “Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study..” J Bone Joint Surg Am 100, no. 8 (April 18, 2018): 666–77. https://doi.org/10.2106/JBJS.17.00154.

PMID
29664853
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Nie, Yong, Jun Ma, ZeYu Huang, Bin Xu, Shuo Tang, Bin Shen, Virginia Byers Kraus, and FuXing Pei. “Upper partial fibulectomy improves knee biomechanics and function and decreases knee pain of osteoarthritis: A pilot and biomechanical study..” J Biomech 71 (April 11, 2018): 22–29. https://doi.org/10.1016/j.jbiomech.2017.12.004.

PMID
29449003
Full Text

Yin, Zhaoxue, Jing Chen, Jian Zhang, Zeping Ren, Kui Dong, Virginia B. Kraus, Zhuoqun Wang, et al. “Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study..” Nutrients 10, no. 4 (April 9, 2018). https://doi.org/10.3390/nu10040464.

PMID
29642510
Full Text

Huebner, J. L., C. Haraden, Y. -. J. Li, and V. B. Kraus. “BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE.” In Osteoarthritis and Cartilage, 26:S42–S42. ELSEVIER SCI LTD, 2018.

Scholars@Duke

Goode, A., V. B. Kraus, Y. Golightly, J. Huebner, S. George, J. Martin, L. DeFrate, and J. M. Jordan. “ASSOCIATION BETWEEN N-CADHERIN, KERATIN-19 AND LUMICAN WITH DISC SPACE NARROWING: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT.” Osteoarthritis and Cartilage 26 (April 1, 2018): S421–S421.

Scholars@Duke

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