Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Hsueh, M-F, Kraus, VB, and Önnerfjord, P. "Cartilage matrix remodelling differs by disease state and joint type." European Cells & Materials 34 (August 24, 2017): 70-82.

PMID
28836259
Full Text

Deveza, LA, Kraus, VB, Collins, JE, Guermazi, A, Roemer, FW, Bowes, M, Nevitt, MC, Ladel, C, and Hunter, DJ. "Association Between Biochemical Markers of Bone Turnover and Bone Changes on Imaging: Data From the Osteoarthritis Initiative." Arthritis Care & Research 69, no. 8 (August 2017): 1179-1191.

PMID
27723280
Full Text

Montell, E, Stabler, TV, Verges, J, and Kraus, VB. "CHONDROITIN SULFATE INHIBITS MONOCYTE CHEMOATTRACTANT PROTEIN-1 RELEASE FROM 3T3-L1 ADIPOCYTES: A NEW TREATMENT OPPORTUNITY FOR OBESITY-RELATED METABOLIC SYNDROMES?." August 2017.

Scholars@Duke

Nwosu, LN, Allen, M, Wyatt, L, Huebner, JL, Chapman, V, Walsh, DA, and Kraus, VB. "Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA." Osteoarthritis and Cartilage 25, no. 6 (June 2017): 858-865.

PMID
28087412
Full Text

Montell, E, Stabler, TV, and Kraus, VB. "CHONDROITIN SULPHATE INHIBITS MONOCYTE CHEMOATTRACTANT PROTEIN-1 RELEASE FROM 3T3L1 ADIPOCYTES: A NEW TREATMENT OPPORTUNITY FOR OBESITY-RELATED METABOLIC SYNDROMES?." June 2017.

Full Text

Liu, B, Goode, AP, Carter, TE, Utturkar, GM, Huebner, JL, Taylor, DC, Moorman, CT, Garrett, WE, Kraus, VB, Guilak, F, DeFrate, LE, and McNulty, AL. "Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients." Connective Tissue Research 58, no. 3-4 (May 2017): 305-316.

PMID
27813662
Full Text

Adams, SB, Leimer, EM, Setton, LA, Bell, RD, Easley, ME, Huebner, JL, Stabler, TV, Kraus, VB, Olson, SA, and Nettles, DL. "Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures." Foot & Ankle International 38, no. 5 (May 2017): 479-484.

PMID
28142266
Full Text

Huebner, J, Furman, B, Kimmerling, K, Olson, S, Guilak, F, and Kraus, V. "Identification of biomarkers indicative of synovitis in the mouse articular fracture model of PTA." April 2017.

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Furman, B, Kimmerling, K, Ramamoorthy, S, Li, Y-J, Wu, Y-H, Huebner, J, Guilak, F, Kraus, V, and Olson, S. "Articular fracture upregulates lipid metabolites in human synovial fluid." April 2017.

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Conaghan, P, Strand, V, Hunter, D, Kraus, V, Berenbaum, F, Katz, N, Lufkin, J, Johnson, J, Kelley, S, and Bodick, N. "An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis: post-hoc pooled analyses of 3 randomized controlled trials." April 2017.

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