Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Carlson, Cathy S., Farshid Guilak, Thomas P. Vail, Jean F. Gardin, and Virginia B. Kraus. “Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee..” J Orthop Res 20, no. 1 (January 2002): 92–100. https://doi.org/10.1016/S0736-0266(01)00066-3.

PMID
11853096
Full Text

Vilím, V., R. Vytásek, M. Olejárová, S. Machácek, J. Gatterová, B. Procházka, V. B. Kraus, and K. Pavelka. “Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis..” Osteoarthritis Cartilage 9, no. 7 (October 2001): 612–18. https://doi.org/10.1053/joca.2001.0434.

PMID
11597173
Full Text

Wang, J. Y., A. E. Baer, V. B. Kraus, and L. A. Setton. “Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture..” Spine (Phila Pa 1976) 26, no. 16 (August 15, 2001): 1747–51. https://doi.org/10.1097/00007632-200108150-00003.

PMID
11493844
Full Text

Hale, L. P., A. G. Clark, J. Li, P. K. Greer, and V. Byers Kraus. “Age-related thymic atrophy in the guinea pig..” Dev Comp Immunol 25, no. 5–6 (June 2001): 509–18. https://doi.org/10.1016/s0145-305x(00)00071-9.

PMID
11356230
Full Text

St Clair, E. W., W. E. Wilkinson, D. S. Pisetsky, D. J. Sexton, R. Drew, V. B. Kraus, and R. A. Greenwald. “The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial..” Arthritis Rheum 44, no. 5 (May 2001): 1043–47. https://doi.org/10.1002/1529-0131(200105)44:5<1043::AID-ANR183>3.0.CO;2-C.

PMID
11357896
Full Text

Baer, A. E., J. Y. Wang, V. B. Kraus, and L. A. Setton. “Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures..” J Orthop Res 19, no. 1 (January 2001): 2–10. https://doi.org/10.1016/S0736-0266(00)00003-6.

PMID
11332616
Full Text

Månsson, B., D. Heinegård, and T. Saxne. “Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al..” Arthritis Rheum 43, no. 6 (June 2000): 1425–27. https://doi.org/10.1002/1529-0131(200006)43:6<1425::AID-ANR33>3.0.CO;2-X.

PMID
10857808
Full Text

Kraus, Virginia B., Amy G. Clark, Joanne M. Jordan, Anca D. Dragomir, Gheorghe Luta, and Vladimir Vilim. “Reply.” Arthritis & Rheumatism 43, no. 6 (June 2000): 1426–27. https://doi.org/10.1002/1529-0131(200006)43:6<1426::aid-anr34>3.0.co;2-t.

Full Text

Lindhorst, E., T. P. Vail, F. Guilak, H. Wang, L. A. Setton, V. Vilim, and V. B. Kraus. “Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis..” J Orthop Res 18, no. 2 (March 2000): 269–80. https://doi.org/10.1002/jor.1100180216.

PMID
10815829
Full Text

Setton, L. A., A. E. Baer, J. Y. Wang, and V. B. Kraus. “Biosynthesis of intervertebral disc matrix in vitro.” Annual International Conference of the Ieee Engineering in Medicine and Biology  Proceedings 2 (December 1, 1999).

Scholars@Duke

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