Wendy P O'Meara, PhD

Associate Professor in Medicine
Associate Research Professor of Global Health
Campus mail Eldoret Kenya, Box 90519, Durham, NC 27710
Phone (919) 681-7711
Email address wendy.omeara@duke.edu

Dr. O'Meara has been working in the field of malaria diagnosis, treatment, and drug resistance since 2004. She is an Associate Professor at Duke University Medical School in the Division of Infectious Diseases, visiting professor at Moi University, and the Co-Field Director of Research for AMPATH.  She has been based full-time in Kenya since 2007.

Dr. O’Meara’s team is interested in improving rational drug use for suspected malaria fevers through expanding the use of diagnostic tools in the community and in health facilities.  As many as 90% of fevers that seek treatment in the formal sector receive antimalarials, and it is estimated that only 20% of those buying antimalarials over-the-counter in the retail sector actually have malaria.  Such overuse poses a significant threat to the continued efficacy of first-line antimalarials. Dr. O’Meara has conducted several randomized controlled trials in western Kenya to test interventions designed to improve the use of information from malaria diagnostic testing in order to target antimalarials to those with confirmed infection. In 2005, she helped to establish the Malaria Diagnostic Centre of Excellence in Kisumu, Kenya.

Recently, she concluded a case-controlled study with colleagues at Moi University that identified the major determinants of insecticide treated bednet failure in western Kenya. Among other results, the study showed that asymptomatically infected household members may be a risk factor for children living in the same household. Current work is extending this observation by leveraging variability in key parasite genes to describe the spatial mixing of malaria infections and track generations of infections from humans to mosquitoes (collaboration with Steve Taylor’s lab).

Dr. O’Meara has experience in marrying innovative spatial techniques with epidemiologic outcomes.  Recent work includes an analysis of health systems factors that contribute to early childhood mortality in sub-Saharan Africa.

Education and Training

  • Ph.D., Massachusetts Institute of Technology, 2003

Publications

O’Meara, Wendy Prudhomme, Mazie Barcus, Chansuda Wongsrichanalai, Sinuon Muth, Jason D. Maguire, Robert G. Jordan, William R. Prescott, and F Ellis McKenzie. “Reader technique as a source of variability in determining malaria parasite density by microscopy..” Malaria Journal 5 (December 12, 2006). https://doi.org/10.1186/1475-2875-5-118.

PMID
17164007
Full Text

Mckenzie, F Ellis, Chansuda Wongsrichanalai, Alan J. Magill, J Russ Forney, Barnyen Permpanich, Carmen Lucas, Laura M. Erhart, et al. “Gametocytemia in Plasmodium vivax and Plasmodium falciparum infections..” J Parasitol 92, no. 6 (December 2006): 1281–85. https://doi.org/10.1645/GE-911R.1.

PMID
17304807
Full Text

Maguire, Jason D., Edith R. Lederman, Mazie J. Barcus, Wendy A Prudhomme O’Meara, Robert G. Jordon, Socheat Duong, Sinuon Muth, et al. “Production and validation of durable, high quality standardized malaria microscopy slides for teaching, testing and quality assurance during an era of declining diagnostic proficiency..” Malar J 5 (October 25, 2006). https://doi.org/10.1186/1475-2875-5-92.

PMID
17062168
Full Text

Hofman, Karen, Andrea Ryce, Wendy Prudhomme, and Sheldon Kotzin. “Reporting of non-communicable disease research in low- and middle-income countries: a pilot bibliometric analysis..” J Med Libr Assoc 94, no. 4 (October 2006): 415–20.

PMID
17082833
Scholars@Duke

Prudhomme O’Meara, Wendy, Shon Remich, Bernhards Ogutu, Martin Lucas, Ramadan Mtalib, Peter Obare, Frederick Oloo, et al. “Systematic comparison of two methods to measure parasite density from malaria blood smears..” Parasitol Res 99, no. 4 (September 2006): 500–504. https://doi.org/10.1007/s00436-006-0135-x.

PMID
16572338
Full Text

McKenzie, F Ellis, David L. Smith, Wendy P. O’Meara, J Russ Forney, Alan J. Magill, Barnyen Permpanich, Laura M. Erhart, Jeeraphat Sirichaisinthop, Chansuda Wongsrichanalai, and Robert A. Gasser. “Fever in patients with mixed-species malaria..” Clin Infect Dis 42, no. 12 (June 15, 2006): 1713–18. https://doi.org/10.1086/504330.

PMID
16705577
Full Text

O’Meara, Wendy Prudhomme, David L. Smith, and F Ellis McKenzie. “Potential impact of intermittent preventive treatment (IPT) on spread of drug-resistant malaria..” Plos Med 3, no. 5 (May 2006). https://doi.org/10.1371/journal.pmed.0030141.

PMID
16573365
Full Text

Maguire, J. D., E. R. Lederman, P. Projodipuro, M. J. Barcus, R. G. Jordon, W. Prudhomme O’Meara, S. Duong, et al. “Standaradized Giemsa-stained blood films for external validation of competency in malaria microscopy.” Malaria Journal 5:92 (2006).

Scholars@Duke

Breman, Joel G., and Wendy Prudhomme O’Meara. “Intermittent preventive treatment for malaria in infants: moving forward, cautiously..” J Infect Dis 192, no. 11 (December 1, 2005): 1869–71. https://doi.org/10.1086/497702.

PMID
16267756
Full Text

O’Meara, Wendy Prudhomme, and F Ellis McKenzie. “The impact of diagnostic technique on vaccine efficacy measurements in clinical trials.” American Journal of Tropical Medicine and Hygiene 73, no. 6 (December 1, 2005): 208–208.

Scholars@Duke

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