Yongmei Liu, MD, PhD

Instructor in the Department of Medicine
Member of Duke Molecular Physiology Institute
Campus mail 300 N. Duke Street, Durham, NC 27701
Email address yongmei.liu@duke.edu

Dr. Yongmei Liu is a genetic epidemiologist with appointments in Cardiology/Medicine and Neurology. Her primary interests are to better understand the molecular mechanisms of aging-related inflammatory diseases including diabetes, atherosclerosis, and Alzheimer’s disease by studying genome, the interplay of genetic and environmental factors, and epigenomic and transcriptomic profiles. The combination of an unbiased genome-wide search in large sample sizes of disease relevant tissues/cells with longitudinal and randomized clinical trial designs, followed up by in vitro and in vivo experiments, is providing novel biomarkers for risk prediction and new insights into mechanisms that are involved in inflammatory diseases.

Education and Training

  • Ph.D., Johns Hopkins Bloomberg School of Public Health, 2004
  • M.D., Bengbu Medical College (China), 1991

Publications

Liang, Jingjing, Brian E. Cade, Karen Y. He, Heming Wang, Jiwon Lee, Tamar Sofer, Stephanie Williams, et al. “Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level..” Am J Hum Genet, October 21, 2019. https://doi.org/10.1016/j.ajhg.2019.10.002.

PMID
31668705
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Sarnowski, Chloé, Aaron Leong, Laura M. Raffield, Peitao Wu, Paul S. de Vries, Daniel DiCorpo, Xiuqing Guo, et al. “Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program..” Am J Hum Genet 105, no. 4 (October 3, 2019): 706–18. https://doi.org/10.1016/j.ajhg.2019.08.010.

PMID
31564435
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Huang, Tao, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y. Millwood, et al. “Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults..” Bmc Med 17, no. 1 (August 30, 2019). https://doi.org/10.1186/s12916-019-1401-y.

PMID
31466528
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Barfield, Richard, Heming Wang, Yongmei Liu, Jennifer A. Brody, Brenton Swenson, Ruitong Li, Traci M. Bartz, et al. “Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations..” Sleep 42, no. 8 (August 1, 2019). https://doi.org/10.1093/sleep/zsz101.

PMID
31139831
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Li, Xinyi, Canqing Yu, Yu Guo, Zheng Bian, Zewei Shen, Ling Yang, Yiping Chen, et al. “Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults..” Eur J Epidemiol 34, no. 8 (August 2019): 753–63. https://doi.org/10.1007/s10654-019-00530-5.

PMID
31152367
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Turcot, Valérie, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, et al. “Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity..” Nat Genet 51, no. 7 (July 2019): 1191–92. https://doi.org/10.1038/s41588-019-0447-2.

PMID
31160809
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Noordam, Raymond, William J. Young, Reem Salman, Jørgen K. Kanters, Marten E. van den Berg, Diana van Heemst, Henry J. Lin, et al. “Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals..” J Am Coll Cardiol 73, no. 24 (June 25, 2019): 3118–31. https://doi.org/10.1016/j.jacc.2019.03.519.

PMID
31221261
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Vries, Paul S. de, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Karen Schwander, et al. “Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions..” Am J Epidemiol 188, no. 6 (June 1, 2019): 1033–54. https://doi.org/10.1093/aje/kwz005.

PMID
30698716
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Wang, Lu, Guangfu Jin, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, et al. “Cancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank..” Int J Cancer, May 22, 2019. https://doi.org/10.1002/ijc.32394.

PMID
31115907
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Ma, Jiantao, Jana Nano, Jingzhong Ding, Yinan Zheng, Rachel Hennein, Chunyu Liu, Elizabeth K. Speliotes, et al. “A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease..” Diabetes 68, no. 5 (May 2019): 1073–83. https://doi.org/10.2337/DB18-1193.

PMID
30936141
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Pages