From the Director

What Did I Read This Week?
submitted by: Coral Giovacchini , MD
Reference:Rubin, LG and Schaffner, W. Care of the Asplenic Patient. N Engl J Med 2014; 371: 349-356.
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Over the past few weeks, the care of asplenic patients has come up several times in sign outs, VA case conferences, and even alluded to during our recent SAR Emergency Lecture series and a Chair’s Conference Case this past month. This clinical practice review was recently published in the NEJM and is a nice summary of the clinical conundrum, treatment guidelines and management considerations in such patients. Clinical Problem Current estimates suggest that there are approximately 1 million total asplenic patients treated currently in the United States. In the article, the authors urge readers to consider the fact that the asplenic population is quite heterogeneous, including not only the typically thought of surgically asplenic patient, but also those with functional asplenic/hyposplenia seen in conference with diseases that we often treat at DUMC/DVAMC including sickle cell anemia, congenital heart disease (i.e. Ivemark Syndrome), untreated HIV, severe celiac disease, and even chronic GvHD. One of the main concerns in caring for these patients is the risk of “post-splenectomy sepsis”, which can carry up to a 50% mortality risk for all-comers, though generally is more fatal is surgically asplenic patients, and has been found to be an independent risk factor for hospitalization for pneumonia or meningitis in military veterans. The pathophysiology behind increased risk of sepsis includes impaired clearance of IgG-coated encapsulated bacteria from the blood stream (remember these are not opsonized as well!) and an overall decreased humoral immunity with lower levels of serum IgM antibodies as well as a lower number of memory B cells to produce IgM. The pathogen classically associated with post-splenectomy sepsis is S. pneumoniae; however other organisms to be considered include H. influenzae b, N. meningitidis, Capnocytophagia canimorsis (after a dog bite), Bebasia (after a tick bite), and Bordatella holmesii. Despite the classical teaching, the most common organisms isolated from adults with bacteremia and underlying functional asplenia from sickle cell disease continue to include gram negative bacilli and S. aureus, often associated with indwelling catheter use. Clincal Strategies There are many areas of uncertainty that remain in the clinical treatment of asplenic patients, including the role of vaccination boosters, the role of prophylactic antibiotics, appropriate empiric antimicrobial treatment strategies and the role of screening for functional asplenia in associated diseases. The most important strategies in our clinical armatorium remain prevention, education, and the early and appropriate treatment of the signs of infection. In 2000, the heptavalent pneumoncoccal conjugate vaccine (PCV7) was introduced, and has markedly reduced the incidence of invasive pneumococcal disease not only among children, but also within the entire US population, presumably via a herd immunity theory. Following this, the triskaidecavalent (PCV13, or Prevnar13) was introduced in 2010 with further reductions in pneumococcal disease in this patient population. Current recommendations for this population are to give PCV13, followed by PPSV23 8 weeks later (this is slightly different after surgical splenectomy, with a recommendation to wait at least 2 weeks after the operation prior to administering PPSV23; CDC.gov has a very comprehensive table on timing of these immunizations). All patients in this population are recommended to get a PPSV23 booster at a sequential 5 year interval. Other immunizations that are recommended including the Hib vaccine for those who were not immunized in childhood, the quadrivalent meningococcal conjugate vaccine (MenACWY), as well as an annual influenza vaccine. With regards to antimicrobial prophylaxis, although this is recommended for all asplenic children <5 years old, this is not necessarily true for adults, and various organizations have published differing guidelines with suggestions ranging from no need for prophylaxis to a call for lifelong penicillin prophylaxis in all persons with surgical asplenia. Though there is not a clear consensus, adults in whom prophylaxis is generally recommended include any patient who has previously survived an episode of post-splenectomy sepsis, or any surgically or functionally asplenic adult who suffers a dog bite (given the risk of C. canimorsus). Once a patient with known asplenia presents with a fever or other localizing signs of infection, prompt initiation of appropriate antimicrobial therapy is warranted (recommendations range from outpatient oral penicillin based regimen to IV 3rd generation or higher cephalosporins- most commonly ceftriaxone) with a goal of covering the above-mentioned organisms. Consideration can be given to adding vancomycin for additional MRSA coverage in the appropriate patient populations (i.e. your patients with indwelling lines, frequent healthcare access, etc), or if CNS disease/infectious meningitis is a concern. Interestingly, because of the high risk of progression to fulminant sepsis, many outpatient care providers have taken the strategy of providing a standing empiric antibiotic prescription for these patients to have available at the first sign of fever or infection. Summary- Remember that “asplenia” can take several forms, including congenital, surgical and functional (i.e. our sickle cell patients!)
- The clinical presentation of asplenic sepsis can be profound and carries up to a 50% mortality risk
- Asplenic patients should be educated that any illness with fever or other localizing signs of infection needs prompt medical attention, and likely should receive prompt initiation of antimicrobial therapy (possibly even self-initiated in the outpatient setting)
- Always be sure to cover encapsulated organisms in patients presenting with asplenic sepsis, with special attention to other environmental risk factors (i.e. dog bites)
- All asplenic patients are recommended to have vaccinations against pneumococci, H. influenzae b, meningococci, as well as an annual influenza vaccine
- Strongly consider lifelong prophylactic antimicrobial therapy in any adult having already survived an episode of asplenic sepsis with a typical organism
QI Corner
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From the Chief Residents
Grand Rounds
Fri., Sept.5, 2014: Dr. Richard Reidel, OncologyNoon Conference
Date | Topic | Lecturer | Time | Vendor |
9/2/14 | SAR Emergency Series: Pneumonia/Debriefing | Titerence/Galanos | 12:15 | Dominos |
9/3/14 | SAR Emergency Series: Common HIV Management Questions | Brice Lefler | 12:15 | Cosmic Cantina |
9/4/14 | SAR Emergency Series: Endocrine Emergencies | Claire Kappa | 12:15 | Subway |
9/5/14 | ITEs - No Conference | Chick-Fil-A | ||
From the Residency Office
ITEs Start This Week!
Friday, September 5th marks the first testing date for the ITEs! House staff - please check your Amion to know what date you are scheduled to take the exam. As a reminder, the exams are being administered electronically this year! Please be sure to review the information below and contact Jen Averitt in the MedRes office if you have any questions. Good luck!! The following is important information – PLEASE REVIEW CAREFULLY BEFORE your test date!- Please take a few minutes to take a practice test at http://acp.startpractice.com Please try and practice BEFORE 9/2/14 as the test may become unavailable after the national testing window opens
- The testing center is located at 406 Oregon St, Lab 101, Durham There is free parking in front of the building
- Please be at the testing center NO LATER THAN 8:00 am on test day!!
- There is no food allowed inside the testing room, but a boxed lunch will be provided for you in the building. You will be allowed a 30 minute lunch break.
ETHOS for Noon Conference Attendance Tracking!
After much work with the wonderful folks in the ETHOS offices, as of September 2, 2014 we will be able to track Internal Medicine Noon Conference attendance using the ETHOS system. From September 2-5, we will continue to use the old badge swipe system in addition to ETHOS so everybody can get used to the process, but as of 9/8/14 we will ONLY use ETHOS for tracking attendance. Most of you should already have an ETHOS account which you use for tracking your attendance at Grand Rounds, but EVERYONE should read the following instructions carefully, as it applies to new and current account holders. you MUST have your Duke Unique ID entered in to you ETHOS account in order for the system to work properly! How do I Set up an ETHOS account for the first time? How to register with Ethos- Go to the Duke Continuing Medical Education home page.
- In the upper right corner, click Join. The Account Information page opens.
- Complete the fields on the screen. A field with an asterisk is required.
- NOTE: Please make sure you include your Duke Unique ID– even though it does not show as a required field.
- Be sure to include your mobile phone number; you will use this number to send a text message with a code supplied at each event and get credit for CME events you attend.
- At the bottom of the account information form, click Create New Account. A green feedback message near the top of the screen informs you that a confirmation has been sent to the email address you provided.
- Open the email (from dcri.cme@dm.duke.edu) and click the top link in the body of the message.
- In your browser window, enter a password of your choice in both fields and note your user name. Click Save at the bottom of the page.
- In the same window, click the Mobile settings tab in the gray menu bar at the top of the page. If you entered your mobile number when you registered, it should appear on this page. Click confirm number. You will receive a text message to that mobile number with a confirmation code from DCRI CME.
- Enter the confirmation code in the box in your browser window and click Confirm Number. A message will appear below your number saying “Your number has been confirmed.”
- Now when you attend an event for CME credit you can use your registered mobile phone to text the provided event codes and earn CME credit.
- The 6-character SMS code will be provided on a slide during your CME event.
- Begin a new text message on your registered mobile phone. Note: The provided code is only good for eight hours. You must text the code the day you attend Medicine Grand Rounds.
- In the To field, enter the Duke CME phone number: 919-213-8033. Tip: Add this number to your mobile phone contacts.
- In the message area, type the 6-character SMS code that was provided during the session (note: this code is not case sensitive).
- Press send.
- If you have set up your Ethos account, you will receive the successful confirmation text message, “Your attendance has been recorded for “[Name of Session].”
- Log into Ethos by visiting the Duke Continuing Education home page and click Log In at the top right of the page.
- Enter your username and password. Click My Account in the upper right corner.
- Under My Profile, click Edit
- Scroll down until you see Duke Unique ID filed. make sure it is correct
- Save the changes to you My Profile page
Recycle Your Old Batteries
In an effort to further our “Go Green” initiative, we are now recycling batteries! We have a dead batteries collection box in the Med Res office (Duke North, Room 8254) so please feel free to bring in your dead batteries and we are happy to recycle them for you. For more information click here.Flu Vaccination Season 2014
As you know, Duke University Health System (DUHS) requires all healthcare workers who perform their duties in a DUHS facility or a community home-based setting to be vaccinated annually against the flu. This is in alignment with our core value of “caring for our patients, their loved ones and each other.” Annual vaccination against influenza, or policy compliance through a granted medical or religious exemption, is a condition of employment for all DUHS employees. Annual vaccination or policy compliance is also a condition of access to Duke Medicine facilities for those holding clinical privileges in a Duke Medicine facility and learners who wish to train in our facilities. With this in mind, please note these key dates for this flu vaccination season:- Start of Flu Vaccination Season: Thursday, September 18, 2014
- Applications for Medical or Religious Exemption should be submitted before Friday, October 17, 2014. This will allow sufficient time for review and for communication of the review decision. Please note: Due to the availability of an egg-free formulation of the flu vaccine, egg allergy will no longer be a valid reason for a medical exemption.
- Policy compliance through vaccination or granted exemption by Monday, November 17, 2014
Now Accepting Applications for Global Health Elective Rotations
The Hubert-Yeargan Center for Global Health (HYC) is now accepting applications for Global Health Elective Rotations for July 2015 and March 2016. Application is open to residents from the Departments of Medicine and Pediatrics: Internal Medicine (PGY 2); Med-Peds (PGY 3); Med-Psych (PGY 4); Pediatrics (PGY 2). The application is attached and available at http://dukeglobalhealth.org or submit online http://bit.do/HYC-submit. (Application addendum is available by request – tara.pemble@duke.edu). Interviews will be held in October. For more information about this opportunity, contact Tara Pemble, Program Coordinator at tara.pemble@duke.edu or 668-8352. Application Deadline: September 30, 2014What is the GME Incentive Program?
The GME Incentive program was started July 2012 as a collaboration between hospital, GME, and Internal Medicine program leadership in order to:- Engage trainees in hospital-based quality improvement
- Provide exposure to models of pay for performance
- Educate trainees in quality improvement
- Provide a focus for ACGME program requirements and CLER visits
- HCAHPS Patient Experience Measurement
- 30-day same hospital readmissions
- Emergency Department Median Consult Time (NEW)
- RL-6 Safety Event Reporting (NEW)
- HCAHPS: As all hospital systems continue to improve, the standards for patient satisfaction will continue to rise as well. Target: Meet the National Median of 87.5% (7 out of 8 dimensions).
- 30-day hospital readmissions: Trainees will have an additional opportunity to demonstrate improvement. Target: 13.05% (median of comparable health care systems on the UHC US News Honor Roll).
- Emergency Department Median Consult Time: Extended consult times in the ED contribute to increased Left Without Being Seen rate and decreased patient satisfaction and care. Target: Overall decrease in consult time by 10%.
- Safety Event Reporting in RL Solutions: Increasing trainee input and awareness for adverse outcomes or near-misses. Trainees only submitted 0.5 (74) of overall reports last year. Target: Increase trainee submitted reports for an average of 2 submissions per trainee.
- HCAHPS (Hospital Consumer Assessment of Healthcare Providers & Systems) surveys: publicly reported data from patient surveys on hospital performance
- Duke Hospital 30-day hospital readmission rate
- Influenza vaccinations
- Hand Hygiene: Internal Medicine, Pediatrics, General Surgery, Anesthesia, Neurology, Orthopedics
- Left Without Being Seen Rate: Emergency Medicine
- OB Trauma: Vaginal with Instrument: OB/GYN
- HCAHPS: Target of 87.5% met
- 30-day hospital readmissions: data unavailable through much of the year
- Influenza vaccinations: data unavailable through much of the year
- Program specific measures: Pediatrics met their target with hand washing.
- GME Performance Incentive Program Year 3 (2014-15 Program Changes and Measures Powerpoint presented at GME PSQC Task Force
- GME Incentive Program Overview Document
Information/Opportunities
Carolinas HealthCare System Internal Medicine Opportunities 8-2014 Announcement Geriatrician Opportunity Elkin Hospitalist Montana Hospitalist Summit Placement Service Washington State Opportunities Madison WI opportunities www.mercydesmoines.orgUpcoming Dates and Events
September 2 - 18: Internal Medicine In-Service Training Exams Testing WindowUseful links
- August 14 Resp Fit Testing-T-Dap-TB Skin Testing Flyer2
- https://intranet.dm.duke.edu/influenza/SitePages/Home.aspx
- http://duke.exitcareoncall.com/.
- Main Internal Medicine Residency website
- Main Curriculum website
- Ambulatory curriculum wiki
- Department of Medicine
- Confidential Comment Line Note: ALL submissions are strictly confidential unless you chose to complete the optional section requesting a response