Department of Medicine faculty have received notice of the following research, clinical trials, CME or other training awards.
[tabs style="vertical"][tab title="Sponsored research"]Geoffrey S. Ginsburg of Cardiology has received an award (W911NF-14-1-0052) from the Defense Advanced Research Projects Agency for a project entitled "Validation of the host transcription diagnostic for prediction of incipient respiratory viral infection." Total funding will be $980,467.
L. Kristin Newby of Cardiology has received a sub-award (1UM-1DK100864-01) through the University of North Carolina - Chapel Hill for a project entitled "GDCN Clinical Center-Advancing Clinical Research in Primary Glomerular Disease." Total funding will be $32,433.
Geoffrey Pitt of Cardiology has received an award (2R01-HL071165-11A1) from the National Institutes of Health for a project entitled "Calcium regulation and dysregulation of cardiac ion channels." Total funding will be $1,737,809.
Matthew T. Roe of Cardiology has received an award from the American Heart Association for a project entitled "Mission Lifeline." Total funding will be $744,071.
Gillian D. Schmidler of Cardiology has received an award from the Patient-Centered Outcomes Research Institute for a project entitled "PCORI Triage and FR Prioritization - Amendment #4." Total funding will be $10,590.
Sudha Shenoy of Cardiology has received an award (1R01-HL118369-01A1) from the National Institutes of Health for a project entitled "Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20." Total funding will be $2,314,745.
Laura M. Wingler (Mentor: Robert J. Lefkowitz) of Cardiology has received an award (1F32-HL121892-01) from the National Institutes of Health for a project entitled "Beta2-adrenergic receptor mutagenesis for studies of biased agonism." Total funding will be $52,190.
Matthew J. Wolf of Cardiology has received an award from the Amyloidosis Foundation, Inc. for a project entitled "Suppressors of Familial Amyloid Cardiomyopathy." Total funding will be $100,000.
Matthew D. Hirschey of Endocrinology, Metabolism, and Nutrition has received an award (1R01-AG045351-01A1) from the National Institutes of Health for a project entitled "Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease." Total funding will be $357,294.
Vivian H. Chu of Infectious Diseases has received an award from the National Institutes of Health for a project entitled "A Phase lll Multi-Center, Randomized, Open-label, Comparative Study to Assess the Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Patients with Intravenous Catheter-Associated Bloodstream Infections (BSI) due to Staphylococci."
Sarah S. Lewis of Infectious Diseases has received a sub-award (1R18-HS022467-01) through the University of Iowa for a project entitled "Implementation and Effectiveness of a S. aureus Surgical Site Infection Prevention Bundle." Total funding will be $105,761.
Mehri McKellar of Infectious Diseases has received a sub-award (5U56-PS003658-03) through the NC DHHS for a project entitled "Healthy Relationships: Region Seven Prevention for Positives." Total funding will be $60,000.
Mehri McKellar of Infectious Diseases has received a sub-award (5U62-PS003977-02) through the NC Dept of Health and Human Services for a project entitled "Care and Prevention in the United States (CAPUS), Patient Navigator Project." Total funding will be $50,000.
Chris Woods of Infectious Diseases has received an award from the North Carolina Biotechnology Center for a project entitled "Emerging Vectorborne Diseases in the Southeastern United States: An Evaluation for National and Global Security." Total funding will be $5,000.
Chris Woods of Infectious Diseases has received an award from the Duke-NUS Graduate Medical School Singapore for a project entitled "Sri Lanka Emerging Acute Respiratory Infection and Febrile Illness Characterization Study." Total funding will be $70,000.
Qingyi Wei of Medical Oncology has received an award (7R01-ES011740-11) from the National Institutes of Health for a project entitled "Molecular Epidemiology of DNA Repair in Head and Neck Cancer." Total funding will be $74,203.
Lesley H. Curtis of Other Medicine has received a sub-award (HHSF22320091006I) through the Harvard Pilgrim Health Care, Inc. for a project entitled "Sentinel Coordinating Center." Total funding will be $98,693.
Monica Kraft of Pulmonary, Allergy, and Critical Care Medicine has received an award through Mcgill University for a project entitled "Refractory Asthma." Total funding will be $21,350.
Neil R. MacIntyre of Pulmonary, Allergy, and Critical Care Medicine has received a sub-award (R01-HL089897-) through the National Jewish Medical and Research Center for a project entitled "COPD Genetic Epidemiology Program - Clinical Center Site Agreement." Total funding will be $27,367.[/tab][tab title="Industry-sponsored clinical trials"]John H. Alexander of Cardiology has received an award from CSL Limited for a project entitled "CSL112 in Adults with ST Segment Elevation." Total funding will be $7,457,899.
Terry A. Fortin of Cardiology has received an award from the Lung Rx, Inc. for a project entitled "BPS-314d-MR-PAH-302. BEAT: A Multicenter, Doubled-Blind, Randomized, Placebo-Controlled, Phase 3 Study To Assess The Efficacy And Safety of Oral B." Total funding will be $253,348.
William S. Jones of Cardiology has received an award from Boston Scientific Corporation for a project entitled "Lower Extremity Chronic Total Occlusion (CTO) Revascularization at Duke." Total funding will be $19,496.
Robert J. Noveck of Cardiology has received an award from Pfizer, Inc. for a project entitled "Phase I B5211007." Total funding will be $1,004,288.
Chetan B. Patel of Cardiology has received an award from ResMed Corp for a project entitled "Cardiovascular Improvements with Minute Ventilation-targeted ASV Therapy in Heart Failure." Total funding will be $395,813.
Manesh R. Patel of Cardiology has received an award from St. Jude Medical Inc. for a project entitled "Multi-center, randomized, single-blind, sham controlled clinical investigation of renal denervation for uncontrolled hypertension." Total funding will be $899,036.
Meena P. Rao (Mentor: Adrian F. Hernandez) of Cardiology has received an award from Medtronic, Inc. for a project entitled "MEDUSA: Variation in Syncope Testing Strategies among Medicare Beneficiaries." Total funding will be $38,375.
Zainab Samad of Cardiology has received an award from Boston Scientific Corporation for a project entitled "Severe Aortic Stenosis and LV Dysfunction: A Multimarker Approach to Risk Prediction." Total funding will be $49,855.
Andrew Wang of Cardiology has received an award from Gilead Sciences, Inc. for a project entitled "Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery: Pilot, Screening Study." Total funding will be $534,995.
John R. Guyton of Endocrinology, Metabolism, and Nutrition has received an award from Sanofi US for a project entitled "EFC13786: Efficacy and Safety of Alirocumab in Patients with Primary Hypercholesterolemia not Treated with a Statin." Total funding will be $416,206.
Hans L. Tillmann of Gastroenterology has received an award from Sanofi US for a project entitled "Pancreatic Assessment Program." Total funding will be $507,191.
Cristina Gasparetto of Hematological Malignancies and Cellular Therapy has received an award from Pharmacyclics, Inc. for a project entitled "Phase 1/2b study of Ibrutinib with Carlfizomib with R/R Myeloma." Total funding will be $462,558.
Mitchell E. Horwitz of Hematological Malignancies and Cellular Therapy has received an award from Gamida Cell Ltd for a project entitled "Long Term Follow Up for Patients who have received Allogeneic Stem Cell Transplantation of NiCord, Umbilical Cord Blood-derived Ex Vivo Expanded Stem and Progenitor Cells." Total funding will be $47,368.
Murat O. Arcasoy of Hematology has received an award from Gilead Sciences, Inc. for a project entitled "A Phase 3, Randomized, Double-blind Active-controlled Study Evaluating Momelotinib vs. Ruxolitinib in Subjects with Primary Myelofibrosis (PMF) or Post-Polycythemia Vera or Post- Essential Thrombocythemia Myelofibrosis (Post-PV/ET MF)." Total funding will be $129,605.
Ara D. Metjian of Hematology has received an award from Baxter Healthcare Corporation for a project entitled "A Phase 3b continuation Study of the Safety and Efficacy of Prophylactic BAX 855 in PTPs with Severe Hemophilia A." Total funding will be $144,044.
Nirmish R. Shah of Hematology has received an award from Selexys Pharmaceuticals Corp for a project entitled "SUSTAIN (A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SEIGI With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises." Total funding will be $278,560.
Barbara D. Alexander of Infectious Diseases has received an award from Viamet Pharmaceuticals for a project entitled "Activity of VT1161 and VT1598 Against Candida Isolates Clinically Resistant to Azole and Echinocandin Antifungal Agents." Total funding will be $9,577.
Andrew Armstrong of Medical Oncology has received an award from Astellas Scientific and Medical Affairs, Inc. for a project entitled "Elucidating Mechanisms of Cell Survival Following Treatment with Enzalutamide and Opportunities for Synergistic Combination Approaches." Total funding will be $199,356.
Jeffrey Crawford of Medical Oncology has received an award from AstraZeneca Pharmaceuticals, LP for a project entitled "A phase III, double-blind, randomized, placebo-controlled study to assess the efficacy and safety of selumetinib (AZD624; ARRY-142886) Hyd-Sulfate) in combination with Docetaxel, in patients receiving second line treatment for KRAS Mutation-Positive." Total funding will be $289,123.
Neal E. Ready of Medical Oncology has received an award from Stem CentRx, Inc. for a project entitled "Phase I/II open label dose escalation study of the safety, pharmacokinetics, and preliminary efficacy of SCI6D6.5 as a single agent in patients with recurrent small cell lung cancer." Total funding will be $112,220.
Neil L. Spector of Medical Oncology has received an award from SRA International, Inc. for a project entitled "Scientific Reserach and Prevention Programs Committee Member Agreement." Total funding will be $6,500.
John H. Strickler of Medical Oncology has received an award from AbbVie Inc. for a project entitled "A Multicenter Phase I/Ib open label dose escalation study of ABBV-399, and antibody drug conjugate, in subjects with advanced solid tumors." Total funding will be $795,833.[/tab]
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