New funding awards - March 2014

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Department of Medicine faculty have received notice of the following research, clinical trials, CME or other training awards. [tabs style="vertical"][tab title="Sponsored research"]Melvin R. Echols of Cardiology has received an award from the National Institutes of Health for a project entitled "Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction." Gary M. Felker of Cardiology has received an award from the National Institutes of Health for a project entitled "NEAT." L. Kristin Newby of Cardiology has received an award from the Society of Cardiovascular Patient Care, Inc for a project entitled "Predicting New Heart Failure Events Using Metabolic Profiling." Total funding will be $10,000. Geoffrey Pitt of Cardiology has received an award (2R01-HL071165-11A1) from the National Institutes of Health for a project entitled "Calcium regulation and dysregulation of cardiac ion channels." Total funding will be $1,782,368. Sudha Shenoy of Cardiology has received an award (1R01-HL118369-01A1) from the National Institutes of Health for a project entitled "Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20." Total funding will be $2,362,204. Jonathan A. Stiber of Cardiology has received an award (1R01-HL121531-01) from the National Institutes of Health for a project entitled "Role of Drebrin in Atherosclerosis." Total funding will be $1,373,750. Kevin Thomas of Cardiology has received a sub-award (5U24-MD006941-03) through the University of Texas Health Science Center at Houston for a project entitled "RECRUIT." Total funding will be $12,595. Laura M. Wingler (Mentor: Robert J. Lefkowitz) of Cardiology has received an award (1F32-HL121892-01) from the National Institutes of Health for a project entitled "Beta2-adrenergic receptor mutagenesis for studies of biased agonism." Total funding will be $53,282. Rodger A. Liddle of Gastroenterology has received an award (2R01-DK064213) from the National Institutes of Health for a project entitled "Pathogenic Mechanisms of Pancreatitis." Total funding will be $1,365,900. Matthew L. Maciejewski of General Internal Medicine has received an award from the Robert Wood Johnson Foundation for a project entitled "Laboratory Monitoring in Medicare." Total funding will be $99,977. Adam Perlman of General Internal Medicine has received an award (3R01-AT004623-06S2) from the National Institutes of Health for a project entitled "Exploring Massage Benefits for Arthritis of the Knee (EMBARK)." Total funding will be $177,650. Harvey Jay Cohen of Geriatrics has received an award from the John A. Hartford Foundation, Inc. for a project entitled "John A. Hartford Foundation's Centers of Excellence (CoE)." Total funding will be $146,000. Nelson J. Chao of Hematological Malignancies and Cellular Therapy has received an award from the National Marrow Donor Program for a project entitled "RITN Agreement." Total funding will be $8,000. Stefanie Sarantopoulos of Hematological Malignancies and Cellular Therapy has received an award (W81XWH-11-1-0537) from the Department of Defense for a project entitled "BAFF-Driven Targeted Immunotherapy for Patients with Leukemia." Total funding will be $218,419. John A. Bartlett of Infectious Diseases has received an award (3UM1-AI069484-07S1) from the National Institutes of Health for a project entitled "5UM1-AI069484-07 Supplement." Total funding will be $481,517. Nathan M. Thielman of Infectious Diseases has received a sub-award (5R25-TW0099337-02) through the Vanderbilt University Medical Center for a project entitled "Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)." Total funding will be $35,408. Nathan M. Thielman of Infectious Diseases has received a sub-award (5R25-TW009337-02) through the Vanderbilt University Medical Center for a project entitled "Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)." Total funding will be $24,460. Wendy A. Prudhomme - O'Meara of Infectious Diseases has received an award from the National Institutes of Health for a project entitled "Innovative partnership to target antimalarial subsidies in the retail sector." Total funding will be $1,916,824. Kimberly L. Blackwell of Medical Oncology has received a sub-award (KG111084) through the University of California - San Francisco for a project entitled "Enhancing Efficacy of Chemotherapy in Triple Negatiave/Basal-like Breast Cancer by Targeting Macrophages: A Multicenter Phase Ib/II study of PLX3397 and Eribulin in Patients with Metastatic Breast Cancer." Total funding will be $163,061. Richard F. Riedel of Medical Oncology has received an award from the Sarcoma Alliance for Research Through Collaboration for a project entitled "A blanket protocol to study oral regorafenib in patients with refractory liposarcoma, osteogenic sarcoma, and Ewing/Ewing-like sarcomas." Total funding will be $128,750. Syed Y. Zafar of Medical Oncology has received a sub-award (5U01-CA037447-29) through the Brigham and Women's Hospital for a project entitled "Financial Assistance, Navigation, and Communication Education (FinANCE): Development and pilot testing of a web-based financial toxicity intervention." Total funding will be $157,000. Patrick H. Pun of Nephrology has received an award (1K23-DK098281-01A1) from the National Institutes of Health for a project entitled "Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney Disease." Total funding will be $158,665. John Hollingsworth of Pulmonary, Allergy, and Critical Care Medicine has received a sub-award (3R01-ES013611-08S2) through the University of North Carolina - Chapel Hill for a project entitled "Diesel-induced Alterations of Influenza Infectivity." Total funding will be $117,750. Jennifer L. Ingram of Pulmonary, Allergy, and Critical Care Medicine has received an award from the American Lung Association for a project entitled "Mechanisms that Direct Airway Remodeling in Obese Asthma." Total funding will be $75,000.[/tab][tab title="Industry-sponsored clinical trials"]Pamela S. Douglas of Cardiology has received an award from HeartFlow, Inc. for a project entitled "PLATFORM." Total funding will be $545,515. Christopher Granger of Cardiology has received an award from The Medicines Company for a project entitled "Regional Systems of Care: Education Systems Study." Total funding will be $500,000. Adrian F. Hernandez of Cardiology has received an award from Bristol-Myers Squibb for a project entitled "Adjudication of Clinical Events for the BMS Protocols: BCB118 and BCB120." Total funding will be $260,581. Daniel B. Mark of Cardiology has received an award from Bristol-Myers Squibb Company for a project entitled "Aristotle Part 3." Total funding will be $286,844. Rajendra H. Mehta of Cardiology has received an award from St. Jude Medical Inc. for a project entitled "Portico US IDE Trial." Total funding will be $4,274,812. Robert J. Noveck of Cardiology has received an award from Perosphere, Inc. for a project entitled "PER977 Validation Substudy." Total funding will be $45,944. Jonathan P. Piccini of Cardiology has received an award from Janssen Scientific Affairs, LLC for a project entitled "A randomized, open-label, active-controlled multi-center study to evaluate the safety of rivaroxaban and vitamin K antagonists in subjects undergoing catheter ablation for atrial fibrillation (VENTURE-AF)." Total funding will be $88,652. Andrew J. Muir of Gastroenterology has received an award from Gilead Sciences, Inc. for a project entitled "Gilead HCV and HIV." Total funding will be $357,158. David Rizzieri of Hematological Malignancies and Cellular Therapy has received an award from Stemline Therapeutics, Inc for a project entitled "SL-401 with AML patients or Blastic Plasmacytoid Dendritic Cell Neoplasm." Total funding will be $214,069. David Rizzieri of Hematological Malignancies and Cellular Therapy has received an award from ERYTECH Pharma for a project entitled "Phase I study of L-asparaginase encapsulated in red blood cells (ERYASP) in comb with CALGB regimen during induction and consolidation phases for frontline therapy, patients older than 40 years with Philadelphia chromosome-negative ALL." Total funding will be $149,329. Nirmish R. Shah of Hematology has received an award from Mast Therapeutics, Inc for a project entitled "Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC): A Phase 3 randomized, double-blind, placebo-controlled, multicenter clinical trial of MSY-188 injection in children with Sickle Cell disease experiencing vaso-occlusive crisis." Total funding will be $235,131. Barbara D. Alexander of Infectious Diseases has received an award from Scynexis Inc for a project entitled "Activity of SCY-078 (MK-3118), a new oral glucan synthase inhibitor, against clinical non-Aspergillus mold isolates." Total funding will be $20,567. Susanna Naggie of Infectious Diseases has received an award from Gilead Sciences, Inc for a project entitled "Phase 3 multicenter, open-label study to investigate the efficacy and safety of Sofosbuvir/Ledipasvir fixed-dose combination for 12 weeks in subjects with chronic genotype 1 or 4 HCV and HIV-1 co-infection." Total funding will be $83,692. Jeffrey Crawford of Medical Oncology has received an award from Amgen, Inc. for a project entitled "A randomized, double-blind, multi-center pahes 2 trial of Denosumab in combination with chemotherapy as first-line treatment of metastatic non-small cell lung cancer." Total funding will be $181,220. Herbert I. Hurwitz of Medical Oncology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "Modular Phase II study to link targeted therapy to patients with pathway activated tumors; Module 1 BKM120 for patients with P13K-activated." Total funding will be $84,709. Michael A. Morse of Medical Oncology has received an award from Aduro BioTech for a project entitled "A phase 2B randomized controlled multicenter open-label study of the efficacy and immune responsoe of GVAX pancreas vaccine with cyclophosphamide and CRS-207 compared to chemotherapy." Total funding will be $559,741. Jeffrey Peppercorn of Medical Oncology has received an award from the Alliance for Clinical Trials in Oncology Foundation for a project entitled "Alliance for Clinical Trials in Oncology Ethics Committee." Total funding will be $10,000. Neal E. Ready of Medical Oncology has received an award from the Bristol-Myers Squibb Company for a project entitled "An open-label, randomized, phase 3 trial of Nivolumab vs Investigator's choice chemotherapy as first-line therapy for stge IV or recurrent PD-L1+non-small cell lung cancer." Total funding will be $118,034. John H. Strickler of Medical Oncology has received an award from Dekkun Corporation for a project entitled "A two part phase I multicenter ipen label study of DKN-01 in combination with weekly paclitaxel." Total funding will be $241,371.[/tab] [/tabs]

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