New funding awards - May 2020

Sponsored Research

Deborah Fisher of Gastroenterology has received a sub-award (5U01FD005478) through the Weill Cornell Medicine for a project entitled "Core variable Assessment Towards a NatIonal evaluation Program (CATNIP) - Subcontract with Weill Cornell." Total funding will be $19,872.

Milta Little of Geriatrics has received an award from the Dementia Alliance of North Carolina for a project entitled "Cognitive Stimulation Therapy across a healthcare system to improve clinical outcomes." Total funding will be $100,000.

Kenneth Lyles of Geriatrics has received a sub-award (5R01-AG059417-02) through the California Pacific Medical Center for a project entitled "Trial of Parkinson's And Zoledronic Acid (TOPAZ)." Total funding will be $20,000.

Patrick Sullivan of Geriatrics has received an award (1R21-AG067340-01) from the National Institutes of Health for a project entitled "A Novel Animal Model of Late Onset Alzheimer's Disease." Total funding will be $442,750.

Gregory Taylor of Geriatrics has received an award (1R01-AI145929-01) from the National Institutes of Health for a project entitled "Role of IRGM proteins in immunity to enteric bacteria." Total funding will be $1,602,667.

Nelson Chao of Hematologic Malignancies and Cellular Therapy has received an award (2U19-AI067798-16) from the National Institutes of Health for a project entitled "Administration Core." Total funding will be $11,475,100.

Nelson Chao of Hematologic Malignancies and Cellular Therapy has received an award (2U19-AI067798-16) from the National Institutes of Health for a project entitled "Project 1 CaMKK2: a novel target to mitigate radiation induced injury of the hematopoietic system and the gastrointestinal tract." Total funding will be $0.

Phuong Doan of Hematologic Malignancies and Cellular Therapy has received an award (2U19-AI067798-16) from the National Institutes of Health for a project entitled "Project 2 Endothelial Cell-Derived Extracellular Vesicles for Mitigation of the Hematopoietic Acute Radiation Syndrome." Total funding will be $0.

Mitchell Horwitz of Hematologic Malignancies and Cellular Therapy has received an award from the Fred Hutchinson Cancer Research Center for a project entitled "FH8771_Single Arm." Total funding will be $79,250.

Charity Oyedeji (Mentor: John Strouse) of Hematology has received an award from the American Society of Hematology for a project entitled "2020 ASH RTAF." Total funding will be $70,000.

Marilyn Telen of Hematology has received a sub-award (1UG3-HL143192-01A1) through the University of Pittsburgh for a project entitled "Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE)." Total funding will be $3,301.

Susanna Naggie of Infectious Diseases has received a sub-award (1R01-DK121378-01) through the Indiana University for a project entitled "Ancillary Studies of NAFLD and NASH in HIV infected Adults." Total funding will be $105,648.

Carey Anders of Medical Oncology has received a sub-award (1R01-CA211093-01A) through the University of North Carolina - Chapel Hill for a project entitled "In Vitro Fertilization Outcomes in Women Diagnosed with Cancer." Total funding will be $10,000.

Jennifer Choe of Medical Oncology has received an award from the Rutgers, The State University of New Jersey for a project entitled "Rutgers TVEC+ISS in SCCS." Total funding will be $97,841.

Jennifer Freedman of Medical Oncology has received an award (W81XWH2010483-LC190367) from the Department of Defense for a project entitled "Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer." Total funding will be $503,748.

Brent Hanks of Medical Oncology has received an award (1 R37 -CA249085-01) from the National Institutes of Health for a project entitled "Investigating the PD-L1:NLRP3 signaling axis as a tumor intrinsic mechanism of adaptive resistance to anti-PD-1 antibody immunotherapy." Total funding will be $1,617,867.

Kevin Oeffinger of Medical Oncology has received an award (1R01-CA249568-01) from the National Institutes of Health for a project entitled "Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care." Total funding will be $3,716,692.

John Strickler of Medical Oncology has received an award from the Academic and Community Cancer Research United for a project entitled "A Phase II, Multicenter, Single-Arm Study of Pemigatinib in Patients with Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations." Total funding will be $132,369.

Ting Yang of Nephrology has received an award from the ASN Foundation for Kidney Research for a project entitled "Renal epithelial actions of the prostaglandin EP4 receptor in blood pressure control." Total funding will be $100,000.

Industry-sponsored Clinical Trials

Adrian Hernandez of Cardiology has received an award from Boehringer Ingelheim Pharmaceuticals, Inc. for a project entitled "EMPA MI Jardiance®, empagliflozin." Total funding will be $45,129,196.

Renato Lopes of Cardiology has received an award from Ionis Pharmaceuticals Inc for a project entitled "PRA-Ionis ATTR-CM." Total funding will be $1,672,225.

Renato Lopes of Cardiology has received an award from Bayer Healthcare Pharmaceuticals Inc for a project entitled "Bayer-20115-CONVERT." Total funding will be $1,547,982.

Renato Lopes of Cardiology has received an award from Bayer Healthcare Pharmaceuticals Inc for a project entitled "Bayer-21170-RE-THINc." Total funding will be $764,020.

Renato Lopes of Cardiology has received an award from Theravance Biopharma, Inc. for a project entitled "TD-1473." Total funding will be $110,736.

Robert Mentz of Cardiology has received an award from Cytokinetics, Inc. for a project entitled "Health Economics and Outcomes Research Collaboration." Total funding will be $195,000.

Manesh Patel of Cardiology has received an award from Bayer Pharmaceuticals for a project entitled "Protocol #s 19765, 19766, and 20603: ACS and Afib Trials." Total funding will be $4,177,667.

Manesh Patel of Cardiology has received an award from Amgen, Inc. for a project entitled "Evaluation of Current Lipid Management and Projected Reduction in Clinical Events with Improved Lipid Management within the Duke University Health System." Total funding will be $249,684.

Jonathan Piccini of Cardiology has received an award from Boston Scientific Corporation for a project entitled "Comparison of Anticoagulation with Left Atrial Appendage Closure after AF Ablation." Total funding will be $223,109.

Sudarshan Rajagopal of Cardiology has received an award from Analytics 4 Life for a project entitled "Analytics 4 Life PHDEV Secondary." Total funding will be $52,500.

Sudha Shenoy of Cardiology has received an award from Lexicon Pharmaceuticals for a project entitled "Effect of Lexicon compound LX9211 on Intracellular trafficking of the beta2AR." Total funding will be $55,959.

Manal Abdelmalek of Gastroenterology has received an award from Viking Therapeutics, Inc. for a project entitled "VK2809 A Phase 2b Randomized, Double-Blind, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of VK2809 Administered for 52 Weeks Followed by a 4-Week Off-Drug Phase in Subjects with Biopsy Proven Non-Alcoholic." Total funding will be $523,938.

David Leiman of Gastroenterology has received an award from Phathom Pharmaceuticals, Inc. for a project entitled "A Phase 3, Randomized, Double-Blind, Two-Phase, Multicenter Study toEvaluate the Efficacy and Safety of Vonoprazan 20 mg Compared to Lansoprazole 30 mg for Healing in Patients with Erosive Esophagitis and to Evaluate the Efficacy and Safety of Vonop." Total funding will be $373,099.

Julius Wilder of Gastroenterology has received an award from Sequana Medical NV for a project entitled "Alphapump system in the treatment of refractory or recurrent ascites: a muticenter single arm within subject crossover design pivotal study (The POSEIDON Study)." Total funding will be $324,551.

Mitchell Horwitz of Hematologic Malignancies and Cellular Therapy has received an award from Gamida Cell Ltd for a project entitled "An Open Label Expanded Access Study of Omidubicel, for Allogeneic Transplantation in Patients with Hematological Malignancies." Total funding will be $222,186.

Lindsay Rein of Hematologic Malignancies and Cellular Therapy has received an award from Incyte Corporation for a project entitled "COVID-19 Phase 3 Assess Efficacy of Ruxolitinib." Total funding will be $1,678,869.

Lindsay Rein of Hematologic Malignancies and Cellular Therapy has received an award from Actuate Therapeutics for a project entitled "Phase 2 study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3ss) inhibitor, as a single agent or combined with Ruxolitinib, in patients with myelofibrosis." Total funding will be $205,870.

Vance Fowler of Infectious Diseases has received an award from ContraFect Corporation for a project entitled "A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Adult Patients Receiving Standard of Care Antibiotics for the Treatment of Staphylococcus aureus  Bloodstream Infections (Bacteremia),." Total funding will be $100,481.

Michael Harrison of Medical Oncology has received an award from Jounce Therapeutics for a project entitled "Title Phase 2 Multicenter Trial of ICOS Agonist Monoclonal Antibody (mAb) JTX-2011 and a CTLA-4 inhibitor in PD-1/PD-L1 Inhibitor Experienced Adult Subjects with Non-small Cell Lung Cancer or Urothelial Cancer (Jounce JTX-2011-201; EMERGE)." Total funding will be $10,000.

Sarah Sammons of Medical Oncology has received an award from Eli Lilly and Company for a project entitled "A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination with Abemaciclib to Patients with ER+, HER2-Locally Advanced or Metastatic Breast Cancer." Total funding will be $147,940.

Sarah Sammons of Medical Oncology has received an award from The Bristol-Myers/Sanofi Pharmaceuticals, Inc. Partnership for a project entitled "A randomized Phase II trial of surgery and stereotactic radiosurgery with and without neoadjuvant nivolumab and ipilimumab in patients with surgically-resectable, solid tumor brain metastases." Total funding will be $10,000.

Thomas Stinchcombe of Medical Oncology has received an award from Genentech, Inc. for a project entitled "Single arm phase 2 trial of atezolizumab and bevacizumab in Epidermal Growth Factor Receptor (EGFR) mutant non-small cell lu¬¬ng cancer in patients with disease progression after osimertinib"." Total funding will be $1,000,001.

Opeyemi Olabisi of Nephrology has received an award from Vertex Pharmaceuticals Inc. for a project entitled "A Study of the Prevalence of Apolipoprotein L1 (APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin." Total funding will be $28,956.

Momen Wahidi of Pulmonary has received an award from Lung Therapeutics, Inc. for a project entitled "LTI-01-2001 A Phase 2 randomized placebo controlled double blind dose ranging study evaluating LTI-01 in patients with infected non-draining pleural effusions." Total funding will be $214,118.

Kim Huffman of Rheumatology has received an award from Gilead Sciences, Inc. for a project entitled "The effects of Rheumatoid Arthritis on skeletal muscle." Total funding will be $277,064.

Jennifer Rogers of Rheumatology has received an award from Exagen , Inc. for a project entitled "Biomarkers to distinguish between Type 1 and 2 SLE activity." Total funding will be $214,964.

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