From the Director

What Did I Read This Week (by, Aimee Zaas, MD )
[box] Albuterol-induced lactic acidosis, Liem EB, Mnookin SC, Mahla ME [/box]
We had a patient admitted on gen med with a severe asthma exacerbation. Interestingly, his blood gas was 7.15/35/86 and he had an anion gap....lactate was 9.3. Why? He'd been using his albuterol continuously for 5+ hours. What happened? There are a lot of articles on this, so here is one we read: Anesthesiology. 2003 Aug;99(2):505-6. What happened to our patient is a "type b" lactic acidosis, not the usual type a that is from hypoxia/hypo perfusion. Albuterol stimulates a lot of gluconeogenesis and glycolysis. Therefore, lots of pyruvate is made. Pyruvate typically is broken down to acetyl CoA by pyruvate dehydrogenase as part of the citric acid cycle. Albuterol blocks this, leading to lactate production. To make matters worse, the lipolysis induced by b- agonists makes more Acetyl CoA, which may further block pyruvate entering the citric acid cycle. You have to be careful in this situation because its already hard for your patient to get rid of one acid source (CO2) and tired muscles make more lactic acid. Plus, there are plenty of reports of ex laps, abdominal CTs and other searches for ischemic gut in this setting. What did we do? Gave steroids, less beta agonists and some ipratropruim. Lactate normalized overnight. More importantly, this prompts me to add in the NHLBI asthma guidelines. This reference as definitions, action plan samples, a corticosteroid relative potency calculator and more. http://www.nhlbi.nih.gov/guidelines/asthma/asthsumm.pdfFrom the Chief Residents
Grand Rounds
Grand Rounds will resume on January 11, 2013Noon Conference
Day | Date | Topic | Lecturer | Time | Vendor |
Monday | 12/31 | HOLIDAY | NA | ||
Tuesday | 1/1 | HOLIDAY | NA | ||
Wednesday | 1/2 | HOLIDAY | NA | ||
Thursday | 1/3 | SAR talks | Bonike Oloruntoba, Jason Rose | 12:00 | The Picnic Basket |
Friday | 1/4 | No Chair's Conference Today | Chiefs | 12:00 | Chick-fil-A |
From the Residency Office
Liability Insurance
We are providing the following information for all of our SARs who are now in the process of completing applications for fellowship or medical staff privleges: Insurance coverage provider - Durham Casualty Company, Ltd. Policy Number - 12PL1022-P Mailing Address - DUMC Box 3811, Durham, NC 27710 Phone Number - 919-684-3277 Fax Number - 919-684-6543 Per claim amount - In excess of $3M Aggregate amount - In excess of $20MMKSAP
Reminder - If you participated in the MKSAP order in August, the books are available for pick up in the Med Res office. Please note that they are individually labeled so look for your name. If you chose MKSAP complete or the electronic version, digital orders will be available at the end of January – you will be emailed.Recruiting Dinners and Tour Guide
If you haven't done so already, PLEASE sign up for a Recruitment Dinner and/or to be a Tour Guide on a Recruitment day! The links to sign up for both are below! http://www.signupgenius.com/go/60B084FAEAE2CA13-december http://www.signupgenius.com/go/60B084FAEAE2CA13-december1 Note: The MedRes office will be closed (no admin staff on duty) December 24 - January 1, 2013Contact Information/Opportunities
North Carolina Internal Medicine Idaho Internal MedicineUseful links
- http://duke.exitcareoncall.com/.
- Main Internal Medicine Residency website
- Main Curriculum website
- Ambulatory curriculum wiki
- Confidential Comment Line Note: ALL submissions are strictly confidential unless you chose to complete the optional section requesting a response.
- Department of Medicine