Alexander Grabner, MD

Assistant Professor in Medicine
Affiliate of the Regeneration Next Initiative
Email address alexander.grabner@duke.edu

 I am a medical doctor (MD) with more than 7 years of research experience studying cell biology and pathophysiology in the context of renal disease. The overall goal of my laboratory is to analyze molecular mechanisms that contribute to chronic kidney disease (CKD) and the cardiorenal syndrome. We are interested in characterizing novel signaling pathways that are involved in the development of cardiac remodeling and heart failure, inflammation and that lead to progression of renal disease. Recently, we have demonstrated that fibroblast growth factor (FGF) 23 induces left ventricular hypertrophy (LVH) and that these pro-hypertrophic effects are mediated by FGF receptor (FGFR) 4. Furthermore, we have shown that FGF23 directly targets hepatocytes and thus contributes to systemic inflammation in animal models of CKD. With our ongoing work, we aim to determine, if FGF23 mediated activation of FGFR4 can contribute to other pathophysiologic alterations (e.g. progression of CKD, anemia, inflammation) as seen in CKD.

As a MD performing translational science, I’m highly interested in collaborations with basic as well as clinical scientists with a variety of scientific backgrounds. I firmly believe that collaborating with experts from different disciplines ultimately will help us advancing translational science, especially in order to understand complex molecular pathomechanisms, as found in CKD. Since I work as a basic scientist in a department of medicine, most of my research is and will be associated with relevant clinical problems and questions.

Education and Training

  • Postdoctoral Research Fellow, Nephrology and Hypertension, University of Miami Leonard M. Miller School of Medicine, 2012 - 2016
  • Resident and Postdoctoral Research Fellow, Experimental Nephrology, Munster University or University of Munster, 2009 - 2012
  • M.D., Graz University of Technology (Austria), 2009

Publications

Taylor, Ashlee, Christopher Yanucil, John Musgrove, Melody Shi, Shintaro Ide, Tomokazu Souma, Christian Faul, Myles Wolf, and Alexander Grabner. “FGFR4 does not contribute to progression of chronic kidney disease..” Sci Rep 9, no. 1 (October 1, 2019). https://doi.org/10.1038/s41598-019-50669-0.

PMID
31575945
Full Text

Kogan, Daniel, Alexander Grabner, Christopher Yanucil, Christian Faul, and Vijay Kumar Ulaganathan. “STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion..” J Clin Invest 128, no. 5 (May 1, 2018): 1867–72. https://doi.org/10.1172/JCI96708.

PMID
29438108
Full Text

Krick, Stefanie, Nathalie Baumlin, Sheyla Paredes Aller, Carolina Aguiar, Alexander Grabner, Juliette Sailland, Eliana Mendes, et al. “Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia..” Sci Rep 7, no. 1 (October 30, 2017). https://doi.org/10.1038/s41598-017-14811-0.

PMID
29085059
Full Text

Grabner, Alexander, Karla Schramm, Neerupma Silswal, Matt Hendrix, Christopher Yanucil, Brian Czaya, Saurav Singh, et al. “FGF23/FGFR4-mediated left ventricular hypertrophy is reversible..” Sci Rep 7, no. 1 (May 16, 2017). https://doi.org/10.1038/s41598-017-02068-6.

PMID
28512310
Full Text

Czaya, Brian, Saurav Singh, Christopher Yanucil, Karla Schramm, Christian Faul, and Alexander Grabner. “Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice..” J Vis Exp, no. 121 (March 10, 2017). https://doi.org/10.3791/55319.

PMID
28362385
Full Text

Grabner, Alexander, Ansel P. Amaral, Karla Schramm, Saurav Singh, Alexis Sloan, Christopher Yanucil, Jihe Li, et al. “Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy..” Cell Metab 22, no. 6 (December 1, 2015): 1020–32. https://doi.org/10.1016/j.cmet.2015.09.002.

PMID
26437603
Full Text