Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

McClung, JM, Reinardy, JL, Mueller, SB, McCord, TJ, Kontos, CD, Brown, DA, Hussain, SNA, Schmidt, CA, Ryan, TE, and Green, TD. "Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment." Frontiers in Physiology 6 (January 2015): 161-null.

PMID
26042050
Full Text

Reinardy, JL, Corey, DM, Golzio, C, Mueller, SB, Katsanis, N, and Kontos, CD. "Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway." PloS one 10, no. 10 (January 2015): e0139614-.

PMID
26436659
Full Text

Mueller, SB, and Kontos, CD. "Gene Therapy for the Prevention of Vein Graft Disease." In Translating Gene Therapy to the Clinic: Techniques and Approaches, 227-246. November 17, 2014.

Full Text

Shen, J, Frye, M, Lee, BL, Reinardy, JL, McClung, JM, Ding, K, Kojima, M, Xia, H, Seidel, C, Lima e Silva, R, Dong, A, Hackett, SF, Wang, J, Howard, BW, Vestweber, D, Kontos, CD, Peters, KG, and Campochiaro, PA. "Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4564-4576.

PMID
25180601
Full Text

Kontos, CD. "More than skin deep: connecting melanocyte pigmentation and angiogenic diseases." The Journal of Clinical Investigation 124, no. 1 (January 2014): 76-79.

PMID
24355914
Full Text

Duscha, BD, Robbins, JL, Kontos, CD, Kraus, WE, and Annex, BH. "Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle." (December 1, 2013): 99-134. (Chapter)

Scholars@Duke

Kontos, CD, and Willett, CG. "Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation." J Natl Cancer Inst 105, no. 16 (August 21, 2013): 1163-1165.

PMID
23899554
Full Text

Southerland, KW, Frazier, SB, Bowles, DE, Milano, CA, and Kontos, CD. "Gene therapy for the prevention of vein graft disease." Translational Research : the Journal of Laboratory and Clinical Medicine 161, no. 4 (April 2013): 321-338. (Review)

PMID
23274305
Full Text

Lee, C-L, Moding, EJ, Cuneo, KC, Li, Y, Sullivan, JM, Mao, L, Washington, I, Jeffords, LB, Rodrigues, RC, Ma, Y, Das, S, Kontos, CD, Kim, Y, Rockman, HA, and Kirsch, DG. "p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice." Science signaling 5, no. 234 (July 24, 2012): ra52-.

PMID
22827996
Full Text

McClung, JM, McCord, TJ, Keum, S, Johnson, S, Annex, BH, Marchuk, DA, and Kontos, CD. "Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice." The American Journal of Pathology 180, no. 5 (May 2012): 2156-2169.

PMID
22445571
Full Text

Pages