Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Chen, L, Xu, B, Liu, L, Luo, Y, Zhou, H, Chen, W, Shen, T, Han, X, Kontos, CD, and Huang, S. "Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death." Free Radic Biol Med 50, no. 5 (March 1, 2011): 624-632.

PMID
21195169
Full Text

Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model." Am J Physiol Heart Circ Physiol 298, no. 6 (June 2010): H2174-H2191.

PMID
20382861
Full Text

Furgeson, SB, Simpson, PA, Park, I, Vanputten, V, Horita, H, Kontos, CD, Nemenoff, RA, and Weiser-Evans, MCM. "Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation." Cardiovasc Res 86, no. 2 (May 1, 2010): 274-282.

PMID
20051384
Full Text

Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use." J Cell Mol Med 14, no. 3 (March 2010): 528-552. (Review)

PMID
19840194
Full Text

Sagana, RL, Yan, M, Cornett, AM, Tsui, JL, Stephenson, DA, Huang, SK, Moore, BB, Ballinger, MN, Melonakos, J, Kontos, CD, Aronoff, DM, Peters-Golden, M, and White, ES. "Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression." J Biol Chem 284, no. 47 (November 20, 2009): 32264-32271.

PMID
19808686
Full Text

Ahmed, A, Fujisawa, T, Niu, X-L, Ahmad, S, Al-Ani, B, Chudasama, K, Abbas, A, Potluri, R, Bhandari, V, Findley, CM, Lam, GKW, Huang, J, Hewett, PW, Cudmore, M, and Kontos, CD. "Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide." Circ Res 104, no. 12 (June 19, 2009): 1333-1336.

PMID
19461044
Full Text

Wu, FTH, Stefanini, MO, Mac Gabhann, F, Kontos, CD, Annex, BH, and Popel, AS. "Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport." Physiol Genomics 38, no. 1 (June 10, 2009): 29-41.

PMID
19351908
Full Text

Lima, B, Lam, GKW, Xie, L, Diesen, DL, Villamizar, N, Nienaber, J, Messina, E, Bowles, D, Kontos, CD, Hare, JM, Stamler, JS, and Rockman, HA. "Endogenous S-nitrosothiols protect against myocardial injury." Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297-6302.

PMID
19325130
Full Text

Qiu, W, Federico, L, Naples, M, Avramoglu, RK, Meshkani, R, Zhang, J, Tsai, J, Hussain, M, Dai, K, Iqbal, J, Kontos, CD, Horie, Y, Suzuki, A, and Adeli, K. "Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins." Hepatology 48, no. 6 (December 2008): 1799-1809.

PMID
19026012
Full Text

Estrada, R, Zeng, Q, Lu, H, Sarojini, H, Lee, J-F, Mathis, SP, Sanchez, T, Wang, E, Kontos, CD, Lin, C-Y, Hla, T, Haribabu, B, and Lee, M-J. "Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells." J Biol Chem 283, no. 44 (October 31, 2008): 30363-30375.

PMID
18765664
Full Text

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