Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Bussolati, B, Dunk, C, Grohman, M, Kontos, CD, Mason, J, and Ahmed, A. "Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide." The American Journal of Pathology 159, no. 3 (September 2001): 993-1008.

PMID
11549592
Full Text

Huang, L, Sankar, S, Lin, C, Kontos, CD, Schroff, AD, Cha, EH, Feng, SM, Li, SF, Yu, Z, Van Etten, RL, Blanar, MA, and Peters, KG. "HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity." J Biol Chem 274, no. 53 (December 31, 1999): 38183-38188.

PMID
10608891
Scholars@Duke

Kontos, CD. "Inhibition of rat vascular smooth muscle cell proliferation in vitro and in vivo by recombinant replication-competent herpes simplex virus - Editorial Comment." STROKE 30, no. 11 (November 1999): 2438-2439.

Scholars@Duke

Kontos, CD, and Annex, BH. "Angiogenesis." Curr Atheroscler Rep 1, no. 2 (September 1999): 165-171. (Review)

PMID
11122706
Scholars@Duke

Calvert, JT, Riney, TJ, Kontos, CD, Cha, EH, Prieto, VG, Shea, CR, Berg, JN, Nevin, NC, Simpson, SA, Pasyk, KA, Speer, MC, Peters, KG, and Marchuk, DA. "Allelic and locus heterogeneity in inherited venous malformations." Human Molecular Genetics 8, no. 7 (July 1999): 1279-1289.

PMID
10369874
Full Text

Kontos, CD. "Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits - Comment." STROKE 30, no. 1 (January 1999): 125-125.

Scholars@Duke

Kontos, CD. "Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats - Comment." STROKE 29, no. 8 (August 1998): 1697-1697.

Scholars@Duke

Kontos, CD, Stauffer, TP, Yang, WP, York, JD, Huang, L, Blanar, MA, Meyer, T, and Peters, KG. "Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt." Molecular and Cellular Biology 18, no. 7 (July 1998): 4131-4140.

PMID
9632797
Full Text

Peters, KG, Coogan, A, Berry, D, Marks, J, Iglehart, JD, Kontos, CD, Rao, P, Sankar, S, and Trogan, E. "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." British Journal of Cancer 77, no. 1 (January 1998): 51-56.

PMID
9459145
Full Text

Kontos, CD. "Intravenous basic fibroblast growth factor decreases brain injury resulting from focal ischemia in cats - Comment." STROKE 28, no. 3 (March 1997): 615-616.

Scholars@Duke

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