Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993


Kumagai, A., S. K. O. Mann, M. Pupillo, G. Pitt, P. N. Devreotes, and R. A. Firtel. “A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 675–85.


Pupillo, M., P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel. “cAMP receptor and G-protein interactions control development in Dictyostelium.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 657–65.


Khazaeli, M. B., W. H. Beierwaltes, G. S. Pitt, G. A. Kabza, K. J. Rogers, and A. F. LoBuglio. “Development and characterization of a monoclonal antibody to human embryonal carcinoma.” J Urol 137, no. 6 (June 1987): 1295–99.

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