Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Hennessey, JA, Jiang, Y, Miller, JD, Stadt, HA, Patrick, W, Pfeiffer, R, Antzelevitch, C, Kanter, R, and Pitt, GS. "A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates." Heart Rhythm 10, no. 11 (November 2013): 1745-.

PMID
24210388
Full Text

Hennessey, JA, Wei, EQ, and Pitt, GS. "Fibroblast growth factor homologous factors modulate cardiac calcium channels." Circ Res 113, no. 4 (August 2, 2013): 381-388.

PMID
23804213
Full Text

Yan, H, Pablo, JL, and Pitt, GS. "FGF14 Regulates Presynaptic Ca2+ Channels and Synaptic Transmission." Cell Reports 4, no. 1 (July 11, 2013): 66-75.

Full Text

Yan, H, Pablo, JL, and Pitt, GS. "FGF14 regulates presynaptic Ca2+ channels and synaptic transmission." Cell Rep 4, no. 1 (July 11, 2013): 66-75.

PMID
23831029
Full Text

Wang, H-G, He, XP, Li, Q, Madison, RD, Moore, SD, McNamara, JO, and Pitt, GS. "The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability." J Biol Chem 288, no. 19 (May 10, 2013): 13258-13268.

PMID
23536187
Full Text

Ramachandran, KV, Hennessey, JA, Barnett, AS, Yin, X, Stadt, HA, Foster, E, Shah, RA, Yazawa, M, Dolmetsch, RE, Kirby, ML, and Pitt, GS. "Calcium influx through L-type Ca(V)1.2 Ca2+ channels regulates mandibular development." JOURNAL OF CLINICAL INVESTIGATION 123, no. 4 (April 2013): 1638-1646.

PMID
23549079
Full Text

Chen, BJ, Jiao, Y, Zhang, P, Sun, AY, Pitt, GS, Deoliveira, D, Drago, N, Ye, T, Liu, C, and Chao, NJ. "Long-term in vivo imaging of multiple organs at the single cell level." PLoS One 8, no. 1 (2013): e52087-.

PMID
23300962
Full Text

Pitt, GS, and Marx, SO. "Calmodulin and CaMKII as Ca<sup>2+</sup> Switches for Cardiac Ion Channels." In Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition, 189-195. January 1, 2013.

Full Text

Daubert, JP, and Pitt, GS. "Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?." J Am Coll Cardiol 60, no. 6 (August 7, 2012): 546-547.

PMID
22726628
Full Text

Stephens, SB, Schisler, JC, Hohmeier, HE, An, J, Sun, AY, Pitt, GS, and Newgard, CB. "A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function." Cell Metab 16, no. 1 (July 3, 2012): 33-43.

PMID
22768837
Full Text

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