Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Klepin, HD, Pitcher, BN, Ballman, KV, Kornblith, AB, Hurria, A, Winer, EP, Hudis, C, Cohen, HJ, Muss, HB, and Kimmick, GG. "Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (alliance)." Journal of oncology practice 10, no. 5 (September 2014): e285-e292.

PMID
25074878
Full Text

Koenig, HG, Berk, LS, Daher, NS, Pearce, MJ, Bellinger, DL, Robins, CJ, Nelson, B, Shaw, SF, Cohen, HJ, and King, MB. "Religious involvement is associated with greater purpose, optimism, generosity and gratitude in persons with major depression and chronic medical illness." Journal of psychosomatic research 77, no. 2 (August 2014): 135-143.

PMID
25077855
Full Text

Sheppard, VB, Faul, LA, Luta, G, Luta, G, Clapp, JD, Yung, RL, Wang, JH-Y, Kimmick, G, Isaacs, C, Tallarico, M, Barry, WT, Pitcher, BN, Hudis, C, Winer, EP, Cohen, HJ, Muss, HB, Hurria, A, and Mandelblatt, JS. "Frailty and adherence to adjuvant hormonal therapy in older women with breast cancer: CALGB protocol 369901." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 22 (August 2014): 2318-2327.

PMID
24934786
Full Text

Hurria, A, Dale, W, Mooney, M, Rowland, JH, Ballman, KV, Cohen, HJ, Muss, HB, Schilsky, RL, Ferrell, B, Extermann, M, Schmader, KE, Mohile, SG, and Cancer and Aging Research Group, . "Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 24 (August 2014): 2587-2594. (Review)

PMID
25071116
Full Text

Hubbard, JM, Cohen, HJ, and Muss, HB. "Incorporating biomarkers into cancer and aging research." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 24 (August 2014): 2611-2616. (Review)

PMID
25071114
Full Text

Hybels, CF, George, LK, Blazer, DG, Pieper, CF, Cohen, HJ, and Koenig, HG. "Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults." Journal of aging and health 26, no. 4 (June 2014): 679-697.

PMID
24728938
Full Text

Tuchman, SA, Shapiro, GR, Ershler, WB, Badros, A, Cohen, HJ, Dispenzieri, A, Flores, IQ, Kanapuru, B, Jurivich, D, Longo, DL, Nourbakhsh, A, Palumbo, A, Walston, J, and Yates, JW. "Multiple myeloma in the very old: an IASIA conference report." Journal of the National Cancer Institute 106, no. 5 (April 3, 2014).

PMID
24700806
Full Text

Kanesvaran, R, Wang, W, Yang, Y, Wei, Z, Jia, L, Li, F, Wu, S, Bai, C, Xie, H, Zhang, H, Yang, G, Sloane, R, Li, P, and Cohen, HJ. "Characteristics and treatment options of elderly Chinese patients with cancer as determined by Comprehensive Geriatric Assessment (CGA)." Journal of geriatric oncology 5, no. 2 (April 2014): 171-178.

PMID
24486112
Full Text

Ballman, KV, Mauer, M, Wedding, U, Mohile, SG, Muss, H, Extermann, M, Luciani, A, Cohen, HJ, Hurria, A, Lichtman, SM, Curigliano, G, and Wildiers, H. "Reply to L.K. Mell et al." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 10 (April 2014): 1090-1091. (Letter)

PMID
24550420
Full Text

Cohen, HJ, Naylor, M, and Hurria, A. "Underrepresentation of older adults in cancer trials--reply." JAMA 311, no. 9 (March 2014): 966-967. (Letter)

PMID
24595790
Full Text

Pages