Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Tallarico, Michael, Jared C. Foster, Drew Seisler, Jacqueline M. Lafky, Arti Hurria, Aminah Jatoi, Harvey J. Cohen, et al. “Frequency and impact of grade three or four toxicities of novel agents on outcomes of older patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma (alliance A151611).” J Geriatr Oncol 9, no. 4 (July 2018): 321–28. https://doi.org/10.1016/j.jgo.2018.03.018.

PMID
29673807
Full Text

Zuo, Xintong, Alison Luciano, Carl F. Pieper, James R. Bain, Virginia B. Kraus, William E. Kraus, Miriam C. Morey, and Harvey J. Cohen. “Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.” J Am Geriatr Soc 66, no. 7 (July 2018): 1353–59. https://doi.org/10.1111/jgs.15393.

PMID
29738072
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Pavon, Juliessa M., Richard J. Sloane, Carl F. Pieper, Cathleen S. Colón-Emeric, Harvey J. Cohen, David Gallagher, Miriam C. Morey, Midori McCarty, Thomas L. Ortel, and Susan N. Hastings. “Automated versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults.” Appl Clin Inform 9, no. 3 (July 2018): 743–51. https://doi.org/10.1055/s-0038-1670678.

PMID
30257260
Full Text

Pavon, Juliessa M., Richard J. Sloane, Carl F. Pieper, Cathleen S. Colón-Emeric, Harvey J. Cohen, David Gallagher, Miriam C. Morey, Midori McCarty, Thomas L. Ortel, and Susan N. Hastings. “Poor Adherence to Risk Stratification Guidelines Results in Overuse of Venous Thromboembolism Prophylaxis in Hospitalized Older Adults.” J Hosp Med 13, no. 6 (June 1, 2018): 403–4. https://doi.org/10.12788/jhm.2916.

PMID
29408946
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Snyder, Peter J., Shalender Bhasin, Glenn R. Cunningham, Alvin M. Matsumoto, Alisa J. Stephens-Shields, Jane A. Cauley, Thomas M. Gill, et al. “Lessons From the Testosterone Trials.” Endocr Rev 39, no. 3 (June 1, 2018): 369–86. https://doi.org/10.1210/er.2017-00234.

PMID
29522088
Full Text

Gajra, Ajeet, Linda McCall, Hyman B. Muss, Harvey J. Cohen, Aminah Jatoi, Karla V. Ballman, Ann H. Partridge, et al. “The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).” J Geriatr Oncol 9, no. 3 (May 2018): 221–27. https://doi.org/10.1016/j.jgo.2018.02.003.

PMID
29602735
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Morrison, Vicki A., Linda McCall, Hyman B. Muss, Aminah Jatoi, Harvey J. Cohen, Constance T. Cirrincione, Jennifer A. Ligibel, Jacqueline M. Lafky, and Arti Hurria. “The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436).” J Geriatr Oncol 9, no. 3 (May 2018): 228–34. https://doi.org/10.1016/j.jgo.2017.11.007.

PMID
29233548
Full Text

Cheong, Yee Ching Vanessa, Mary Cooter, Richard L. Huang, Heather E. Whitson, Harvey J. Cohen, Joseph P. Mathew, and Miles Berger. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” In Anesthesia and Analgesia, 126:353–56. LIPPINCOTT WILLIAMS & WILKINS, 2018.

Scholars@Duke

Demark-Wahnefried, Wendy, Mallory G. Cases, Alan B. Cantor, Andrew D. Frugé, Kerry P. Smith, Julie Locher, Harvey J. Cohen, et al. “Pilot Randomized Controlled Trial of a Home Vegetable Gardening Intervention among Older Cancer Survivors Shows Feasibility, Satisfaction, and Promise in Improving Vegetable and Fruit Consumption, Reassurance of Worth, and the Trajectory of Central Adiposity.” J Acad Nutr Diet 118, no. 4 (April 2018): 689–704. https://doi.org/10.1016/j.jand.2017.11.001.

PMID
29305129
Full Text

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