Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Eriksen, EF, Lyles, KW, Colón-Emeric, CS, Pieper, CF, Magaziner, JS, Adachi, JD, Hyldstrup, L, Recknor, C, Nordsletten, L, Lavecchia, C, Hu, H, Boonen, S, and Mesenbrink, P. "Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture." J Bone Miner Res 24, no. 7 (July 2009): 1308-1313.

PMID
19257818
Full Text

White, HK, Petrie, CD, Landschulz, W, MacLean, D, Taylor, A, Lyles, K, Wei, JY, Hoffman, AR, Salvatori, R, Ettinger, MP, Morey, MC, Blackman, MR, Merriam, GR, and Capromorelin Study Group, . "Effects of an oral growth hormone secretagogue in older adults." The Journal of Clinical Endocrinology and Metabolism 94, no. 4 (April 2009): 1198-1206.

PMID
19174493
Full Text

Warriner, AH, Outman, RC, Saag, KG, Berry, SD, Colón-Emeric, C, Flood, KL, Lyles, KW, Tanner, SB, Watts, NB, and Curtis, JR. "Management of osteoporosis among home health and long-term care patients with a prior fracture." Southern Medical Journal 102, no. 4 (April 2009): 397-404. (Review)

PMID
19279529
Full Text

Curtis, JR, Xi, J, Westfall, AO, Cheng, H, Lyles, K, Saag, KG, and Delzell, E. "Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis." Medical Care 47, no. 3 (March 2009): 334-341.

PMID
19194337
Full Text

Whitson, HE, Sanders, L, Pieper, CF, Gold, DT, Papaioannou, A, Richards, JB, Adachi, JD, Lyles, KW, and CaMos Research Group, . "Depressive symptomatology and fracture risk in community-dwelling older men and women." Aging Clin Exp Res 20, no. 6 (December 2008): 585-592.

PMID
19179844
Scholars@Duke

Curtis, JR, Westfall, AO, Cheng, H, Lyles, K, Saag, KG, and Delzell, E. "Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 23, no. 9 (September 2008): 1435-1441.

PMID
18442318
Full Text

Lyles, KW, Schenck, AP, and Colón-Emeric, CS. "Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa 19, no. 8 (August 2008): 1225-1233.

PMID
18301857
Full Text

Logan, WC, Sloane, R, Lyles, KW, Goldstein, B, and Hoenig, HM. "Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury." Archives of Physical Medicine and Rehabilitation 89, no. 2 (February 2008): 237-243.

PMID
18226646
Full Text

Karam, R, Al-Khalidi, H, and Steinbuch, M. "Zoledronate, fractures, and mortality after hip fracture [3]." New England Journal of Medicine 358, no. 9 (2008): 968--.

Scholars@Duke

Colon-Emeric, CS, Lyles, KW, and Mesenbrink, P. "Zoledronate, fractures, and mortality after hip fracture [4]." New England Journal of Medicine 358, no. 9 (2008): 968-969.

Full Text

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