Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Black, DM, Boonen, S, Delmas, P, and Lyles, KW. "Review of comparative effectiveness of treatments to prevent fractures [4]." Annals of Internal Medicine 148, no. 11 (2008): 885-886.

PMID
18519940
Scholars@Duke

Pieper, CF, Colon-Emeric, C, Caminis, J, Betchyk, K, Zhang, J, Janning, C, Shostak, J, LeBoff, MS, Heaney, RR, and Lyles, KW. "Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture." The American Journal of Geriatric Pharmacotherapy 5, no. 4 (December 2007): 335-340.

PMID
18179991
Full Text

Lyles, KW, Colón-Emeric, CS, Magaziner, JS, Adachi, JD, Pieper, CF, Mautalen, C, Hyldstrup, L, Recknor, C, Nordsletten, L, Moore, KA, Lavecchia, C, Zhang, J, Mesenbrink, P, Hodgson, PK, Abrams, K, Orloff, JJ, Horowitz, Z, Eriksen, EF, Boonen, S, and HORIZON Recurrent Fracture Trial, . "Zoledronic acid and clinical fractures and mortality after hip fracture." The New England Journal of Medicine 357, no. 18 (November 2007): 1799-1809.

PMID
17878149
Full Text

Colón-Emeric, CS, Lyles, KW, House, P, Levine, DA, Schenck, AP, Allison, J, Gorospe, J, Fermazin, M, Oliver, K, Curtis, JR, Weissman, N, Xie, A, and Saag, KG. "Randomized trial to improve fracture prevention in nursing home residents." The American Journal of Medicine 120, no. 10 (October 2007): 886-892.

PMID
17904460
Full Text

Gellad, ZF, and Lyles, KW. "Direct-to-consumer advertising of pharmaceuticals." The American Journal of Medicine 120, no. 6 (June 2007): 475-480. (Review)

PMID
17524744
Full Text

Colón-Emeric, C, Lyles, KW, Levine, DA, House, P, Schenck, A, Gorospe, J, Fermazin, M, Oliver, K, Alison, J, Weisman, N, Xie, A, Curtis, JR, and Saag, K. "Prevalence and predictors of osteoporosis treatment in nursing home residents with known osteoporosis or recent fracture." Osteoporos Int 18, no. 4 (April 2007): 553-559.

PMID
17120179
Full Text

Echols, MR, Garman, KS, and Lyles, KW. "Clinical diagnostic reasoning [14]." New England Journal of Medicine 356, no. 12 (2007): 1272--.

PMID
17380583
Full Text

Lyles, KW. "Bisphosphonates in Paget's disease of bone." Clinical Reviews in Bone and Mineral Metabolism 5, no. 3 (2007): 165-171.

Full Text

Hosking, D, Lyles, K, Brown, JP, Fraser, WD, Miller, P, Curiel, MD, Devogelaer, J-P, Hooper, M, Su, G, Zelenakas, K, Pak, J, Fashola, T, Saidi, Y, Eriksen, EF, and Reid, IR. "Long-term control of bone turnover in paget's disease with zoledronic acid and risedronate (Journal of Bone and Mineral Research (2007) 22, (142-148))." Journal of Bone and Mineral Research 22, no. 5 (2007): 773--.

Full Text

Hosking, D, Lyles, K, Brown, JP, Fraser, WD, Miller, P, Curiel, MD, Devogelaer, J-P, Hooper, M, Su, G, Zelenakas, K, Pak, J, Fashola, T, Saidi, Y, Eriksen, EF, and Reid, IR. "Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate." Journal of Bone and Mineral Research 22, no. 1 (2007): 142-148.

PMID
17032148
Full Text

Pages