Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Gold, DT, Shipp, KM, Pieper, CF, Duncan, PW, Martinez, S, and Lyles, KW. "Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial." J Am Geriatr Soc 52, no. 9 (September 2004): 1471-1478.

PMID
15341548
Full Text

Colón-Emeric, CS, Caminis, J, Suh, TT, Pieper, CF, Janning, C, Magaziner, J, Adachi, J, Rosario-Jansen, T, Mesenbrink, P, Horowitz, ZD, Lyles, KW, and HORIZON Recurrent Fracture Trial, . "The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair." Curr Med Res Opin 20, no. 6 (June 2004): 903-910.

PMID
15200749
Full Text

Lyles, KW, and Colón-Emeric, C. "Treating vitamin D deficiency in long-term care: It should be done yesterday, but how?." Journal of the American Medical Directors Association 5, no. 6 (2004): 416-417.

PMID
15530183
Scholars@Duke

Colón-Emeric, C, Kuchibhatla, M, Pieper, C, Hawkes, W, Fredman, L, Magaziner, J, Zimmerman, S, and Lyles, KW. "The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies." Osteoporos Int 14, no. 11 (November 2003): 879-883.

PMID
14530910
Full Text

Colón-Emeric, CS, Biggs, DP, Schenck, AP, and Lyles, KW. "Risk factors for hip fracture in skilled nursing facilities: who should be evaluated?." Osteoporos Int 14, no. 6 (July 2003): 484-489.

PMID
12730734
Full Text

Suh, TT, and Lyles, KW. "Osteoporosis considerations in the frail elderly." Curr Opin Rheumatol 15, no. 4 (July 2003): 481-486. (Review)

PMID
12819479
Scholars@Duke

Lyles, KW. "What is "resistance" in Paget's disease of bone?." Arthritis and Rheumatism 48, no. 8 (2003): 2097-2099.

PMID
12905461
Full Text

Lyles, KW, and Colón-Emeric, CS. "Can we identify women at high risk of osteoporotic fractures?." J Am Geriatr Soc 50, no. 6 (June 2002): 1161-1162.

PMID
12110083
Scholars@Duke

Cohen, HJ, Feussner, JR, Weinberger, M, Carnes, M, Hamdy, RC, Hsieh, F, Phibbs, C, Courtney, D, Lyles, KW, May, C, McMurtry, C, Pennypacker, L, Smith, DM, Ainslie, N, Hornick, T, Brodkin, K, and Lavori, P. "A controlled trial of inpatient and outpatient geriatric evaluation and management." N Engl J Med 346, no. 12 (March 21, 2002): 905-912.

PMID
11907291
Full Text

Staa, TPV, Selby, P, Leufkens, HGM, Lyles, K, Sprafka, JM, and Cooper, C. "Incidence and natural history of paget's disease of bone in England and Wales." Journal of Bone and Mineral Research 17, no. 3 (2002): 465-471.

PMID
11878305
Scholars@Duke

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