Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Schwartz, EJ, Szczech, LA, Ross, MJ, Klotman, ME, Winston, JA, and Klotman, PE. "Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease." Journal of the American Society of Nephrology : Jasn 16, no. 8 (August 2005): 2412-2420.

PMID
15987747
Full Text

Chang, TL, Vargas, J, DelPortillo, A, and Klotman, ME. "Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity." The Journal of Clinical Investigation 115, no. 3 (March 2005): 765-773.

Full Text

Gillim-Ross, L, Cara, A, and Klotman, ME. "Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors." The Journal of General Virology 86, no. Pt 3 (March 2005): 765-771.

PMID
15722538
Full Text

Chang, TL, Vargas, J, DelPortillo, A, and Klotman, ME. "Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity." J Clin Invest 115, no. 3 (March 2005): 765-773.

PMID
15719067
Full Text

Gillim-Ross, L, Cara, A, and Klotman, ME. "HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages." Viral Immunology 18, no. 1 (January 2005): 190-196.

PMID
15802963
Full Text

Jing, B, Janout, V, Herold, BC, Klotman, ME, Heald, T, and Regen, SL. "Persulfated molecular umbrellas as anti-HIV and anti-HSV agents." Journal of the American Chemical Society 126, no. 49 (December 2004): 15930-15931.

PMID
15584704
Full Text

He, JC, Husain, M, Sunamoto, M, D'Agati, VD, Klotman, ME, Iyengar, R, and Klotman, PE. "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways." The Journal of Clinical Investigation 114, no. 5 (September 2004): 643-651.

Full Text

He, JC, Husain, M, Sunamoto, M, D'Agati, VD, Klotman, ME, Iyengar, R, and Klotman, PE. "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways." J Clin Invest 114, no. 5 (September 2004): 643-651.

PMID
15343382
Full Text

Chang, TL, and Klotman, ME. "Defensins: natural anti-HIV peptides." Aids Reviews 6, no. 3 (July 2004): 161-168. (Review)

PMID
15595433
Scholars@Duke

Cheshenko, N, Keller, MJ, MasCasullo, V, Jarvis, GA, Cheng, H, John, M, Li, J-H, Hogarty, K, Anderson, RA, Waller, DP, Zaneveld, LJD, Profy, AT, Klotman, ME, and Herold, BC. "Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread." Antimicrobial Agents and Chemotherapy 48, no. 6 (June 2004): 2025-2036.

PMID
15155195
Full Text

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