Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Chang, TL, Vargas, J, DelPortillo, A, and Klotman, ME. "Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity." J Clin Invest 115, no. 3 (March 2005): 765-773.

PMID
15719067
Full Text

Chang, TL, Jr, JV, DelPortillo, A, and Klotman, ME. "Dual role of α-defensin-1 in anti-HIV-1 innate immunity." Journal of Clinical Investigation 115, no. 3 (2005): 765-773.

Full Text

Gillim-Ross, L, Cara, A, and Klotman, ME. "HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages." Viral Immunol 18, no. 1 (2005): 190-196.

PMID
15802963
Full Text

Jing, B, Janout, V, Herold, BC, Klotman, ME, Heald, T, and Regen, SL. "Persulfated molecular umbrellas as anti-HIV and anti-HSV agents." J Am Chem Soc 126, no. 49 (December 15, 2004): 15930-15931.

PMID
15584704
Full Text

He, JC, Husain, M, Sunamoto, M, D'Agati, VD, Klotman, ME, Iyengar, R, and Klotman, PE. "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways." J Clin Invest 114, no. 5 (September 2004): 643-651.

PMID
15343382
Full Text

Chang, TL, and Klotman, ME. "Defensins: natural anti-HIV peptides." AIDS Rev 6, no. 3 (July 2004): 161-168. (Review)

PMID
15595433
Scholars@Duke

Cheshenko, N, Keller, MJ, MasCasullo, V, Jarvis, GA, Cheng, H, John, M, Li, J-H, Hogarty, K, Anderson, RA, Waller, DP, Zaneveld, LJD, Profy, AT, Klotman, ME, and Herold, BC. "Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread." Antimicrob Agents Chemother 48, no. 6 (June 2004): 2025-2036.

PMID
15155195
Full Text

Winston, JA, Klotman, PE, and Klotman, M. "Renal Manifestations of HIV Infection." (April 8, 2004): 651-661. (Chapter)

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Vargas, J, Gusella, GL, Najfeld, V, Klotman, ME, and Cara, A. "Novel integrase-defective lentiviral episomal vectors for gene transfer." Hum Gene Ther 15, no. 4 (April 2004): 361-372.

PMID
15053861
Full Text

He, JC, Husain, M, Sunamoto, M, D'Agati, VD, Klotman, ME, Iyengar, R, and Klotman, PE. "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways." Journal of Clinical Investigation 114, no. 5 (2004): 643-651.

Full Text

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