Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Zerhouni-Layachi, Bouchra, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, and Mary E. Klotman. “Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy.” Aids 20, no. 4 (February 28, 2006): 621–24. https://doi.org/10.1097/01.aids.0000210618.68083.8e.

PMID
16470129
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Wyatt, Christina M., Raymond R. Arons, Paul E. Klotman, and Mary E. Klotman. “Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality.” Aids 20, no. 4 (February 28, 2006): 561–65. https://doi.org/10.1097/01.aids.0000210610.52836.07.

PMID
16470120
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Keller, Marla J., Bouchra Zerhouni-Layachi, Natalia Cheshenko, Minnie John, Kathleen Hogarty, Andrea Kasowitz, Cindy L. Goldberg, et al. “PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial.” J Infect Dis 193, no. 1 (January 1, 2006): 27–35. https://doi.org/10.1086/498533.

PMID
16323128
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Husain, Mohammad, Vivette D. D’Agati, John Cijiang He, Mary E. Klotman, and Paul E. Klotman. “HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN.” Aids 19, no. 17 (November 18, 2005): 1975–80. https://doi.org/10.1097/01.aids.0000191918.42110.27.

PMID
16260903
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John, Minnie, Marla J. Keller, Ehsan H. Fam, Natalia Cheshenko, Kathleen Hogarty, Andrea Kasowitz, Sylvan Wallenstein, et al. “Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.” J Infect Dis 192, no. 10 (November 15, 2005): 1731–40. https://doi.org/10.1086/497168.

PMID
16235171
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Scordi-Bello, Irini A., Arevik Mosoian, Cejiang He, Yiban Chen, Yang Cheng, Gary A. Jarvis, Marla J. Keller, et al. “Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action.” Antimicrob Agents Chemother 49, no. 9 (September 2005): 3607–15. https://doi.org/10.1128/AAC.49.9.3607-3615.2005.

PMID
16127029
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Schwartz, Elissa J., Lynda A. Szczech, Michael J. Ross, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman. “Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease.” J Am Soc Nephrol 16, no. 8 (August 2005): 2412–20. https://doi.org/10.1681/ASN.2005040340.

PMID
15987747
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Chang, Theresa L., Jesus Vargas, Armando DelPortillo, and Mary E. Klotman. “Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity.” J Clin Invest 115, no. 3 (March 2005): 765–73. https://doi.org/10.1172/JCI21948.

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15719067
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Gillim-Ross, Laura, Andrea Cara, and Mary E. Klotman. “Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors.” J Gen Virol 86, no. Pt 3 (March 2005): 765–71. https://doi.org/10.1099/vir.0.80570-0.

PMID
15722538
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Gillim-Ross, Laura, Andrea Cara, and Mary E. Klotman. “HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages.” Viral Immunol 18, no. 1 (2005): 190–96. https://doi.org/10.1089/vim.2005.18.190.

PMID
15802963
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