Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box_103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research is funded by a career development award from the Department of Veterans Affairs Office of Research and Development (IK2BX002240) and a Scientist Development Grant from the American Heart Association. In my role as Director of Undergraduate Medical Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I also serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the online nephrology journal club (NephJC). I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular edutainment project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain an advocate for the site and author the yearly “Top Nephrology Stories of the Year”. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences College of Medicine, 2003

Publications

Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Griffiths, RC, Azad, HA, Herrera, M, Gurley, SB, and Coffman, TM. "Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion." Journal of the American Society of Nephrology : JASN 26, no. 12 (December 2015): 2953-2962.

PMID
25855778
Full Text

Roberts, JK, Westphal, S, and Sparks, MA. "Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management." Seminars in dialysis 28, no. 5 (September 2015): 525-529. (Letter)

PMID
26096760
Full Text

Olyaei, AJ, Lerma, EV, Tuchman, SA, and Sparks, MA. "Rational dosing of chemotherapy in patients with kidney failure." In Onconephrology: Cancer, Chemotherapy and the Kidney, 105-129. August 7, 2015.

Full Text

Dimke, H, Sparks, MA, Thomson, BR, Frische, S, Coffman, TM, and Quaggin, SE. "Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney." Journal of the American Society of Nephrology : JASN 26, no. 5 (May 2015): 1027-1038.

PMID
25385849
Full Text

Sparks, MA, Lerma, EV, Kupin, W, Phelan, PJ, Jhaveri, KD, and Topf, J. "NephMadness 2015: nephrology as a cornerstone of medicine." American journal of kidney diseases : the official journal of the National Kidney Foundation 65, no. 3 (March 2015): 375-377.

PMID
25704043
Full Text

Topf, JM, Sparks, MA, Iannuzzella, F, Lerma, E, Oates, T, Phelan, PJ, and Hiremath, S. "Twitter-Based Journal Clubs: Additional Facts and Clarifications." Journal of medical Internet research 17, no. 9 (January 2015): e216-. (Letter)

PMID
26376668
Full Text

Zhang, J, Patel, MB, Griffiths, R, Mao, A, Song, Y-S, Karlovich, NS, Sparks, MA, Jin, H, Wu, M, Lin, EE, and Crowley, SD. "Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension." Hypertension (Dallas, Tex. : 1979) 64, no. 6 (December 2014): 1275-1281.

PMID
25185128
Full Text

Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, and Gbadegesin, RA. "Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis." Kidney international 86, no. 6 (December 2014): 1253-1259.

PMID
25229338
Full Text

Gbadegesin, RA, Hall, G, Adeyemo, A, Hanke, N, Tossidou, I, Burchette, J, Wu, G, Homstad, A, Sparks, MA, Gomez, J, Jiang, R, Alonso, A, Lavin, P, Conlon, P, Korstanje, R, Stander, MC, Shamsan, G, Barua, M, Spurney, R, Singhal, PC, Kopp, JB, Haller, H, Howell, D, Pollak, MR, Shaw, AS, Schiffer, M, and Winn, MP. "Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS." Journal of the American Society of Nephrology : JASN 25, no. 9 (September 2014): 1991-2002.

PMID
24676636
Full Text

Sparks, MA, Crowley, SD, Gurley, SB, Mirotsou, M, and Coffman, TM. "Classical Renin-Angiotensin system in kidney physiology." Comprehensive Physiology 4, no. 3 (July 2014): 1201-1228. (Review)

PMID
24944035
Full Text

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