Matthew A. Sparks, MD

Associate Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin-angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation. 

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

Listen to my podcast "The Nephron Segment"

@Nephro_Sparks on Twitter

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Roberts, John K., Matthew A. Sparks, and Ruediger W. Lehrich. “Medical student attitudes toward kidney physiology and nephrology: a qualitative study.” Ren Fail 38, no. 10 (November 2016): 1683–93. https://doi.org/10.1080/0886022X.2016.1230459.

PMID
27758129
Full Text

Zhang, Jiandong, Nathan P. Rudemiller, Mehul B. Patel, QingQing Wei, Norah S. Karlovich, Alexander D. Jeffs, Min Wu, et al. “Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI.” J Am Soc Nephrol 27, no. 8 (August 2016): 2257–64. https://doi.org/10.1681/ASN.2015060683.

PMID
26744488
Full Text

Cameron, Christian Blake, Vinay Nair, Manu Varma, Martha Adams, Kenar D. Jhaveri, and Matthew A. Sparks. “Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs.” Jmir Med Educ 2, no. 1 (June 23, 2016): e10. https://doi.org/10.2196/mededu.4867.

PMID
27731858
Full Text

Chen, Daian, Johannes Stegbauer, Matthew A. Sparks, Donald Kohan, Robert Griffiths, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension.” Hypertension 67, no. 6 (June 2016): 1291–97. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987.

PMID
27141055
Full Text

Zhang, Jiandong, Nathan P. Rudemiller, Mehul B. Patel, Norah S. Karlovich, Min Wu, Alicia A. McDonough, Robert Griffiths, Matthew A. Sparks, Alexander D. Jeffs, and Steven D. Crowley. “Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.” Cell Metab 23, no. 2 (February 9, 2016): 360–68. https://doi.org/10.1016/j.cmet.2015.11.013.

PMID
26712462
Full Text

Sparks, Matthew A., Johannes Stegbauer, Daian Chen, Jose A. Gomez, Robert C. Griffiths, Hooman A. Azad, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.” J Am Soc Nephrol 26, no. 12 (December 2015): 2953–62. https://doi.org/10.1681/ASN.2014080816.

PMID
25855778
Full Text

Topf, Joel M., Matthew A. Sparks, Francesco Iannuzzella, Edgar Lerma, Thomas Oates, Paul J. Phelan, and Swapnil Hiremath. “Twitter-Based Journal Clubs: Additional Facts and Clarifications.” J Med Internet Res 17, no. 9 (September 16, 2015): e216. https://doi.org/10.2196/jmir.4639.

PMID
26376668
Full Text

Roberts, John K., Scott Westphal, and Matthew A. Sparks. “Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.” Semin Dial 28, no. 5 (September 2015): 525–29. https://doi.org/10.1111/sdi.12400.

PMID
26096760
Full Text

Olyaei, A. J., E. V. Lerma, S. A. Tuchman, and M. A. Sparks. “Rational dosing of chemotherapy in patients with kidney failure.” In Onconephrology: Cancer, Chemotherapy and the Kidney, 105–29, 2015. https://doi.org/10.1007/978-1-4939-2659-6_6.

Full Text

1. Olyaei, A. J., E. Lerma, S. A. Tuchman, and M. A. Sparks. “Rational Dosing of Chemotherapy in Patients with Chronic Kidney Disease.” In Onconephrology Cancer, Chemotherapy and the Kidney, edited by K. D. Jhaveri and A. Salahudeen, 105–29. Springer, 2015.

Scholars@Duke

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