Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Romac, JMJ, McCall, SJ, Humphrey, JE, Heo, J, and Liddle, RA. "Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis." Pancreas 36, no. 4 (May 2008): 394-401.

PMID
18437086
Full Text

Keel, PK, Wolfe, BE, Liddle, RA, De Young, KP, and Jimerson, DC. "Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa." Arch Gen Psychiatry 64, no. 9 (September 2007): 1058-1066.

PMID
17768271
Full Text

Liddle, RA. "The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis." Biochimica Et Biophysica Acta 1772, no. 8 (August 2007): 869-878. (Review)

PMID
17428642
Full Text

Chandra, R, and Liddle, RA. "Cholecystokinin." Current Opinion in Endocrinology, Diabetes, and Obesity 14, no. 1 (February 2007): 63-67. (Review)

PMID
17940422
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Liddle, RA, and Jirtle, RL. "Epigenetic silencing of genes in human colon cancer." Gastroenterology 131, no. 3 (September 2006): 960-962.

PMID
16952566
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Noble, MD, Romac, J, Wang, Y, Hsu, J, Humphrey, JE, and Liddle, RA. "Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats." American Journal of Physiology. Gastrointestinal and Liver Physiology 291, no. 1 (July 2006): G128-G134.

PMID
16769810
Full Text

Liddle, RA. "Pathophysiology of SPINK mutations in pancreatic development and disease." Endocrinol Metab Clin North Am 35, no. 2 (June 2006): 345-x. (Review)

PMID
16632097
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Reeve, JR, Liddle, RA, Shively, JE, Lee, TD, Keire, DA, Chew, P, and Vigna, SR. "Sequence variation outside the "active" region of dog and rabbit cholecystokinin-58 results in bioactivity differences." Pancreas 32, no. 3 (April 2006): 306-313.

PMID
16628087
Full Text

Liddle, RA, Toskes, PP, Horrow, J, Ghali, J, Dachman, A, and Stong, D. "Lack of trophic pancreatic effects in humans with long-term administration of ximelagatran." Pancreas 32, no. 2 (March 2006): 205-210.

PMID
16552342
Full Text

Liddle, RA. "Regulation of Pancreatic Secretion." Physiology of the Gastrointestinal Tract 2 (2006): 1397-1435.

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