Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Liddle, RA. "A unifying principle in training gastroenterologists." Gastroenterology 127, no. 2 (August 2004): 377-.

PMID
15300566
Scholars@Duke

Anderson, AML, Varkey, JB, Petti, CA, Liddle, RA, Frothingham, R, and Woods, CW. "Non-O1 Vibrio cholerae septicemia: case report, discussion of literature, and relevance to bioterrorism." Diagn Microbiol Infect Dis 49, no. 4 (August 2004): 295-297.

PMID
15313536
Full Text

Tashiro, M, Samuelson, LC, Liddle, RA, and Williams, JA. "Calcineurin mediates pancreatic growth in protease inhibitor-treated mice." Am J Physiol Gastrointest Liver Physiol 286, no. 5 (May 2004): G784-G790.

PMID
14684381
Full Text

Liddle, RA, and Nathan, JD. "Neurogenic inflammation and pancreatitis." Pancreatology 4, no. 6 (2004): 551-559. (Review)

PMID
15550764
Full Text

Liddle, RA. "Malcolm P. Tyor, MD, (1923-2003) AGA president 1981-1982." GASTROENTEROLOGY 125, no. 2 (August 2003): 288-288.

Scholars@Duke

Liddle, RA. "Bringing new therapies to patients--what is the proper physician-industry relationship?." Gastroenterology 125, no. 1 (July 2003): 7-.

PMID
12851864
Scholars@Duke

Nolan, LJ, Guss, JL, Liddle, RA, Pi-Sunyer, FX, and Kissileff, HR. "Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans." Nutrition 19, no. 6 (June 2003): 553-557.

PMID
12781859
Scholars@Duke

Liddle, RA. "Cholecystokinin: Its role in health and disease." Current Opinion in Endocrinology and Diabetes 10, no. 1 (2003): 50-54.

Full Text

Nathan, JD, Peng, RY, Wang, Y, McVey, DC, Vigna, SR, and Liddle, RA. "Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats." Am J Physiol Gastrointest Liver Physiol 283, no. 4 (October 2002): G938-G946.

PMID
12223354
Full Text

Nathan, JD, and Liddle, RA. "Neurohormonal control of pancreatic exocrine secretion." Curr Opin Gastroenterol 18, no. 5 (September 2002): 536-544.

PMID
17033330
Scholars@Duke

Pages