Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Liddle, RA, and Jirtle, RL. "Epigenetic silencing of genes in human colon cancer." Gastroenterology 131, no. 3 (September 2006): 960-962.

PMID
16952566
Full Text

Noble, MD, Romac, J, Wang, Y, Hsu, J, Humphrey, JE, and Liddle, RA. "Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats." Am J Physiol Gastrointest Liver Physiol 291, no. 1 (July 2006): G128-G134.

PMID
16769810
Full Text

Liddle, RA. "Pathophysiology of SPINK mutations in pancreatic development and disease." Endocrinol Metab Clin North Am 35, no. 2 (June 2006): 345-x. (Review)

PMID
16632097
Full Text

Reeve, JR, Liddle, RA, Shively, JE, Lee, TD, Keire, DA, Chew, P, and Vigna, SR. "Sequence variation outside the "active" region of dog and rabbit cholecystokinin-58 results in bioactivity differences." Pancreas 32, no. 3 (April 2006): 306-313.

PMID
16628087
Full Text

Liddle, RA, Toskes, PP, Horrow, J, Ghali, J, Dachman, A, and Stong, D. "Lack of trophic pancreatic effects in humans with long-term administration of ximelagatran." Pancreas 32, no. 2 (March 2006): 205-210.

PMID
16552342
Full Text

Liddle, RA. "Regulation of Pancreatic Secretion." Physiology of the Gastrointestinal Tract 2 (2006): 1397-1435.

Full Text

Liddle, RA. "Not for the faint of heart." Gastroenterology 129, no. 5 (November 2005): 1373-.

PMID
16285936
Full Text

Noble, MD, and Liddle, RA. "Neurohormonal control of exocrine pancreatic secretion." Curr Opin Gastroenterol 21, no. 5 (September 2005): 531-537. (Review)

PMID
16093766
Scholars@Duke

Nathan, JD, Romac, J, Peng, RY, Peyton, M, Macdonald, RJ, and Liddle, RA. "Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice." Gastroenterology 128, no. 3 (March 2005): 717-727.

PMID
15765407
Scholars@Duke

McVey, DC, Liddle, RA, Riggs-Sauthier, J, Ekwuribe, N, and Vigna, SR. "Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA." Dig Dis Sci 50, no. 3 (March 2005): 565-573.

PMID
15810644
Scholars@Duke

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