Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Nathan, J. D., A. A. Patel, D. C. McVey, J. E. Thomas, V. Prpic, S. R. Vigna, and R. A. Liddle. “Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis..” Am J Physiol Gastrointest Liver Physiol 281, no. 5 (November 2001): G1322–28. https://doi.org/10.1152/ajpgi.2001.281.5.G1322.

PMID
11668042
Full Text

Nathan, Jaimie D., Douglas C. McVey, Akash Patel, Jean Thomas, Steven R. Vigna, and Rodger A. Liddle. “Vanilloid receptor-1-mediated substance P release in experimental pancreatittis in mice.” Gastroenterology 120, no. 5 (April 2001): A539–A539. https://doi.org/10.1016/s0016-5085(08)82676-5.

Full Text

Patel, Akash A., Jean E. Thomas, Douglas C. McVey, V. Prpic, Steven R. Vigna, and Rodger A. Liddle. “The capsaicin vanilloid receptor-1 (VR-1) mediates a portion of secretagogue-induced pancreatitis in mice.” Gastroenterology 118, no. 4 (April 2000): A169–A169. https://doi.org/10.1016/s0016-5085(00)82753-5.

Full Text

Liddle, R. A. “Regulation of cholecystokinin secretion in humans..” J Gastroenterol 35, no. 3 (2000): 181–87.

PMID
10755686
Scholars@Duke

Shetzline, M. A., and R. A. Liddle. “Neurohumoral control of the exocrine pancreas..” Curr Opin Gastroenterol 15, no. 5 (September 1999): 380–84.

PMID
17023977
Scholars@Duke

Van Dam, J., P. G. Brady, M. Freeman, F. Gress, G. W. Gross, E. Hassall, R. Hawes, et al. “Guidelines for training in electronic ultrasound: guidelines for clinical application. From the ASGE. American Society for Gastrointestinal Endoscopy..” Gastrointest Endosc 49, no. 6 (June 1999): 829–33.

PMID
10343245
Scholars@Duke

Liddle, R. A., V. Prpic, Y. Wang, J. Romac, G. M. Green, and J. R. Reeve. “Luminal cholecystokinin releasing factor (LCRF) stimulates CCK release from intestinal, endocrine cells through a calcium influx pathway..” Gastroenterology 116, no. 4 (April 1, 1999): A622–A622.

Scholars@Duke

Basavappa, S., A. W. Mangel, L. Scott, and R. A. Liddle. “Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II..” Biochemical and Biophysical Research Communications 254, no. 3 (January 1999): 699–702. https://doi.org/10.1006/bbrc.1998.9997.

PMID
9920804
Full Text

McVey, D. C., J. M. Romac, W. C. Clay, T. A. Kost, R. A. Liddle, and S. R. Vigna. “Monitor peptide binding sites are expressed in the rat liver and small intestine..” Peptides 20, no. 4 (1999): 457–64.

PMID
10458515
Scholars@Duke

Prpic, V., J. Gregory Fitz, Y. Wang, J. R. Raymond, M. N. Garnovskaya, and R. A. Liddle. “Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.” American Journal of Physiology  Gastrointestinal and Liver Physiology 275, no. 4 38-4 (November 9, 1998).

Scholars@Duke

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