Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 3126, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Forsha, D, Risum, N, Kropf, PA, Rajagopal, S, Smith, PB, Kanter, RJ, Samad, Z, Sogaard, P, Barker, P, and Kisslo, J. "Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 27, no. 4 (April 2014): 413-422.

PMID
24508364
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Forsha, D, Risum, N, Kropf, PA, Rajagopal, S, Smith, PB, Kanter, RJ, Samad, Z, Sogaard, P, Barker, P, and Kisslo, J. "Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population." Journal of the American Society of Echocardiography 27, no. 4 (January 1, 2014): 413-422.

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Rajagopal, S, Forsha, DE, Risum, N, Hornik, CP, Poms, AD, Fortin, TA, Tapson, VF, Velazquez, EJ, Kisslo, J, and Samad, Z. "Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views." Journal of the American Society of Echocardiography 27, no. 6 (January 1, 2014): 657-665.

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Kahsai, AW, Rajagopal, S, Sun, J, and Xiao, K. "Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry." Nature protocols 9, no. 6 (January 2014): 1301-1319.

PMID
24810039
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Rajagopal, S, Bassoni, DL, Campbell, JJ, Gerard, NP, Gerard, C, and Wehrman, TS. "Biased agonism as a mechanism for differential signaling by chemokine receptors." The Journal of biological chemistry 288, no. 49 (December 2013): 35039-35048.

PMID
24145037
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Rajagopal, S. "Quantifying biased agonism: understanding the links between affinity and efficacy." Nature reviews. Drug discovery 12, no. 6 (June 2013): 483-. (Letter)

PMID
23681006
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Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)." Proceedings of the National Academy of Sciences of the United States of America 109, no. 33 (2012): 13464--.

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Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Mol Pharmacol 80, no. 3 (September 2011): 367-377.

PMID
21610196
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Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. (Published online)" Nature 477, no. 7364 (August 21, 2011): 349-353.

PMID
21857681
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Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor. (Published online)" Nat Chem Biol 7, no. 10 (August 21, 2011): 692-700.

PMID
21857662
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