Sudarshan Rajagopal, MD, PhD

Associate Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 102147, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Xiao, K., J. Sun, J. Kim, S. Rajagopal, B. Zhai, J. Villén, W. Haas, et al. “Erratum: Global phosphorylation analysis of ß-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107).” Proceedings of the National Academy of Sciences of the United States of America 109, no. 33 (August 14, 2012). https://doi.org/10.1073/pnas.1211889109.

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Rajagopal, Sudarshan, Seungkirl Ahn, David H. Rominger, William Gowen-MacDonald, Christopher M. Lam, Scott M. Dewire, Jonathan D. Violin, and Robert J. Lefkowitz. “Quantifying ligand bias at seven-transmembrane receptors..” Mol Pharmacol 80, no. 3 (September 2011): 367–77. https://doi.org/10.1124/mol.111.072801.

PMID
21610196
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Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor..” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.

PMID
21857662
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Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1..” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.

PMID
21857681
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Nobles, Kelly N., Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, et al. “Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin..” Sci Signal 4, no. 185 (August 9, 2011). https://doi.org/10.1126/scisignal.2001707.

PMID
21868357
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Rajagopal, Sudarshan, Jeff Kovacs, Cristian Badea, G Allan Johnson, Howard A. Rockman, Claude A. Piantadosi, and Robert J. Lefkowitz. “BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION.” Journal of the American College of Cardiology 57, no. 14 (April 2011): E2046–E2046. https://doi.org/10.1016/s0735-1097(11)62046-9.

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Xiao, Kunhong, Jinpeng Sun, Jihee Kim, Sudarshan Rajagopal, Bo Zhai, Judit Villén, Wilhelm Haas, et al. “Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)..” Proc Natl Acad Sci U S A 107, no. 34 (August 24, 2010): 15299–304. https://doi.org/10.1073/pnas.1008461107.

PMID
20686112
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Rajagopal, Sudarshan, Keshava Rajagopal, and Robert J. Lefkowitz. “Teaching old receptors new tricks: biasing seven-transmembrane receptors..” Nat Rev Drug Discov 9, no. 5 (May 2010): 373–86. https://doi.org/10.1038/nrd3024.

PMID
20431569
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Rajagopal, Sudarshan, Jihee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, and Robert J. Lefkowitz. “Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7..” Proc Natl Acad Sci U S A 107, no. 2 (January 12, 2010): 628–32. https://doi.org/10.1073/pnas.0912852107.

PMID
20018651
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