Susanna Naggie, MD

Professor of Medicine
Vice Dean for Clinical Research
Member in the Duke Clinical Research Institute
Campus mail 300 West Morgan St, Suite 800, Durham, NC 27701
Phone (919) 684-2584
Email address susanna.naggie@duke.edu

Dr. Susanna Naggie completed her medical education at Johns Hopkins School of Medicine and her internal medicine training at Duke University Medical Center (DUMC), where she also served as a Chief Resident in Internal Medicine.  She completed her Infectious Diseases (ID) fellowship training at Duke and then joined the faculty in the Division of ID. She is an Associate Professor of Medicine with Tenure and currently holds joint appointments at the Duke Clinical Research Institute (DCRI, Director of ID Research), and at the Durham Veterans Affairs Medical Center (DVAMC). Dr. Naggie has dedicated her academic career to the care of patients with HIV and viral hepatitis, with a research program focused on understanding the mechanisms of accelerated liver fibrogenesis in this population and the extrahepatic health outcomes attributed to HCV in persons with HIV infection. In addition to her investigator-initiated research program, Dr. Naggie is also involved in multiple clinical trials and clinical registries with a particular focus on HIV and liver disease. She is the prior co-Chair of the AASLD/IDSA HCV Guidance Committee and is currently Chair of the AIDS Clinical Trials Group Viral Hepatitis Transformative Science Group Committee and a member of the DHHS Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the CDC/NIH/IDSA-HIVMA Opportunistic Infections Guideline Committee. For the past two years Dr. Naggie has served as the Medical Director of the Duke Department of Medicine Clinical Research Unit.

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 2007 - 2009
  • Chief Medical Resident - VAMC, Medicine, Duke University, 2006 - 2007
  • Medical Resident, Medicine, Duke University, 2002 - 2005
  • M.D., Johns Hopkins University, 2002

Publications

Norton, Brianna L., Lawrence Park, Leah J. McGrath, Rae Jean Proeschold Bell, Andrew J. Muir, and Susanna Naggie. “Health care utilization in HIV-infected patients: assessing the burden of hepatitis C virus coinfection.” Aids Patient Care Stds 26, no. 9 (September 2012): 541–45. https://doi.org/10.1089/apc.2012.0170.

PMID
22860997
Full Text

Clark, Paul J., Alexander J. Thompson, Qianqian Zhu, David M. Vock, Mingfu Zhu, Keyur Patel, Stephen A. Harrison, et al. “The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.” Dig Dis Sci 57, no. 8 (August 2012): 2213–21. https://doi.org/10.1007/s10620-012-2171-y.

PMID
22543885
Full Text

Naggie, Susanna, Anu Osinusi, Antonios Katsounas, Richard Lempicki, Eva Herrmann, Alexander J. Thompson, Paul J. Clark, et al. “Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response.” Hepatology 56, no. 2 (August 2012): 444–54. https://doi.org/10.1002/hep.25647.

PMID
22331604
Full Text

Osinusi, Anu, Susanna Naggie, Seerat Poonia, Martin Trippler, Zonghui Hu, Emily Funk, Joerg Schlaak, et al. “ITPA gene polymorphisms significantly affect hemoglobin decline and treatment outcomes in patients coinfected with HIV and HCV.” J Med Virol 84, no. 7 (July 2012): 1106–14. https://doi.org/10.1002/jmv.23302.

PMID
22585729
Full Text

Clark, P. J., A. J. Thompson, M. Zhu, D. M. Vock, Q. Zhu, D. Ge, K. Patel, et al. “Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.” J Viral Hepat 19, no. 5 (May 2012): 332–40. https://doi.org/10.1111/j.1365-2893.2011.01553.x.

PMID
22497812
Full Text

Naggie, Susanna, and Mark S. Sulkowski. “Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.” Gastroenterology 142, no. 6 (May 2012): 1324-1334.e3. https://doi.org/10.1053/j.gastro.2012.02.012.

PMID
22537439
Full Text

Rallón, Norma I., Vincent Soriano, Susanna Naggie, Clara Restrepo, John McHutchison, Eugenia Vispo, and José M. Benito. “Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV.” J Antimicrob Chemother 67, no. 5 (May 2012): 1246–49. https://doi.org/10.1093/jac/dkr598.

PMID
22294646
Full Text

Clark, Paul J., Alexander J. Thompson, Alison Jazwinski, Hans L. Tillmann, Susanna Naggie, Andrew J. Muir, and Keyur Patel. “Association of Serum Adipocytokines With IL28B and SVR in Chronic Hepatitis C.” In Gastroenterology, 142:S968–69. W B SAUNDERS CO-ELSEVIER INC, 2012.

Scholars@Duke

Proeschold-Bell, Rae Jean, Ashwin A. Patkar, Susanna Naggie, Lesleyjill Coward, Paolo Mannelli, Jia Yao, Patricia Bixby, and Andrew J. Muir. “An integrated alcohol abuse and medical treatment model for patients with hepatitis C.” Dig Dis Sci 57, no. 4 (April 2012): 1083–91. https://doi.org/10.1007/s10620-011-1976-4.

PMID
22134784
Full Text

Jazwinski, A. B., A. J. Thompson, P. J. Clark, S. Naggie, H. L. Tillmann, and K. Patel. “Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis.” J Viral Hepat 19, no. 4 (April 2012): 278–82. https://doi.org/10.1111/j.1365-2893.2011.01546.x.

PMID
22404726
Full Text

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